STRINGSTRING
rad9a rad9a spidr spidr ercc6 ercc6 LOC108265819 LOC108265819 blm blm mfsd11 mfsd11 xrcc6 xrcc6 wrn wrn xrra1 xrra1 LOC108279384 LOC108279384 xrcc2 xrcc2 LOC108255000 LOC108255000 ect2 ect2 smpd1 smpd1 abraxas1 abraxas1 nabp1 nabp1 cdca7l cdca7l kdm1a kdm1a dcun1d3 dcun1d3 topbp1 topbp1 rad51ap1 rad51ap1 xrcc5 xrcc5 rad1 rad1 LOC108280750 LOC108280750 uimc1 uimc1 stk11 stk11 babam1 babam1 tgfb3 tgfb3 brat1 brat1 bard1 bard1 ercc8 ercc8 atm atm msh2 msh2 ENSIPUP00000013129 ENSIPUP00000013129 abcg5 abcg5 LOC108255148 LOC108255148 LOC108255290 LOC108255290 ENSIPUP00000013983 ENSIPUP00000013983 kars1 kars1 babam2 babam2 itgb6 itgb6 brcc3 brcc3 ENSIPUP00000016196 ENSIPUP00000016196 LOC108272203 LOC108272203 elk1 elk1 LOC108267470 LOC108267470 ikbip ikbip ercc1 ercc1 LOC108277601 LOC108277601 mrnip mrnip brca2 brca2 LOC108262800 LOC108262800 lig4 lig4 LOC108280806 LOC108280806 zmpste24 zmpste24 LOC108270970 LOC108270970 tank tank ENSIPUP00000021843 ENSIPUP00000021843 atr atr bax bax chek2 chek2 rad51 rad51 ints3 ints3 rfwd3 rfwd3 ticrr ticrr rhno1 rhno1 eya3 eya3 cop1 cop1 men1 men1 sirt1 sirt1 ino80 ino80 FBXO4 FBXO4 fancd2 fancd2 LOC108257192 LOC108257192 xrcc4 xrcc4 ptprc ptprc inip inip cdca7 cdca7 map3k20 map3k20 rnf168 rnf168 rnf8 rnf8 brca1 brca1 LOC108259721 LOC108259721 tp53bp1 tp53bp1 mdm2 mdm2 rad9b rad9b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (384 aa)
spidrDNA repair-scaffolding protein isoform X2. (862 aa)
ercc6DNA excision repair protein ERCC-6. (1409 aa)
LOC108265819DNA (Cytosine-5)-methyltransferase 3A-like isoform X2; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1521 aa)
blmBloom syndrome protein isoform X1. (1132 aa)
mfsd11UNC93-like protein MFSD11. (453 aa)
xrcc6X-ray repair cross-complementing protein 6. (609 aa)
wrnWerner syndrome ATP-dependent helicase isoform X1. (1429 aa)
xrra1X-ray radiation resistance-associated protein 1 isoform X1. (648 aa)
LOC108279384Transforming growth factor beta; Belongs to the TGF-beta family. (380 aa)
xrcc2DNA repair protein XRCC2. (307 aa)
LOC108255000SOSS complex subunit B1-A-like. (192 aa)
ect2Protein ECT2 isoform X7. (974 aa)
smpd1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (598 aa)
abraxas1BRCA1-A complex subunit Abraxas. (393 aa)
nabp1SOSS complex subunit B2. (213 aa)
cdca7lCell division cycle-associated 7-like protein. (473 aa)
kdm1aLysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (850 aa)
dcun1d3DCN1-like protein. (303 aa)
topbp1DNA topoisomerase 2-binding protein 1 isoform X7. (1561 aa)
rad51ap1RAD51-associated protein 1. (349 aa)
xrcc5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (726 aa)
rad1Cell cycle checkpoint protein RAD1 isoform X1. (291 aa)
LOC108280750Transforming growth factor beta; Belongs to the TGF-beta family. (381 aa)
uimc1BRCA1-A complex subunit RAP80 isoform X1. (960 aa)
stk11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (439 aa)
babam1BRISC and BRCA1-A complex member 1. (369 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
brat1BRCA1-associated ATM activator 1. (782 aa)
bard1BRCA1-associated RING domain protein 1. (729 aa)
ercc8DNA excision repair protein ERCC-8. (397 aa)
atmNon-specific serine/threonine protein kinase. (3076 aa)
msh2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (938 aa)
ENSIPUP00000013129annotation not available (130 aa)
abcg5ATP-binding cassette sub-family G member 5. (655 aa)
LOC108255148Deoxyribonuclease; Belongs to the DNase I family. (284 aa)
LOC108255290Deoxyribonuclease; Belongs to the DNase I family. (282 aa)
ENSIPUP00000013983annotation not available (125 aa)
kars1Lysine--tRNA ligase. (606 aa)
babam2BRCA1-A complex subunit BRE. (386 aa)
itgb6Integrin beta; Belongs to the integrin beta chain family. (753 aa)
brcc3Lys-63-specific deubiquitinase BRCC36 isoform X1. (260 aa)
ENSIPUP00000016196annotation not available (490 aa)
LOC108272203Growth arrest and DNA damage-inducible protein GADD45 alpha-like. (210 aa)
elk1ETS domain-containing protein Elk-1. (577 aa)
LOC108267470Apoptosis regulator Bcl-2-like. (204 aa)
ikbipInhibitor of nuclear factor kappa-B kinase-interacting protein isoform X1. (421 aa)
ercc1DNA excision repair protein ERCC-1. (367 aa)
LOC108277601Alpha-crystallin B chain-like; Belongs to the small heat shock protein (HSP20) family. (167 aa)
mrnipUPF0544 protein C5orf45 homolog. (380 aa)
brca2Breast cancer type 2 susceptibility protein isoform X1. (2673 aa)
LOC108262800Uncharacterized protein LOC108262800. (218 aa)
lig4DNA ligase. (909 aa)
LOC108280806Growth arrest and DNA damage-inducible protein GADD45 alpha-like. (158 aa)
zmpste24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (470 aa)
LOC108270970Apoptosis regulator BAX-like. (202 aa)
tankTRAF family member-associated NF-kappa-B activator isoform X2. (344 aa)
ENSIPUP00000021843Secreted frizzled-related protein 2 like. (231 aa)
atrSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2616 aa)
baxApoptosis regulator BAX. (189 aa)
chek2Serine/threonine-protein kinase Chk2. (539 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (372 aa)
ints3Integrator complex subunit 3 isoform X3. (1033 aa)
rfwd3E3 ubiquitin-protein ligase RFWD3. (698 aa)
ticrrTreslin. (1839 aa)
rhno1RAD9, HUS1, RAD1-interacting nuclear orphan protein 1. (293 aa)
eya3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (659 aa)
cop1E3 ubiquitin-protein ligase RFWD2 isoform X1. (692 aa)
men1Menin. (616 aa)
sirt1NAD-dependent protein deacetylase sirtuin-1 isoform X3. (731 aa)
ino80DNA helicase INO80. (1495 aa)
FBXO4F-box only protein 4-like. (157 aa)
fancd2Fanconi anemia group D2 protein isoform X2. (1438 aa)
LOC108257192UNC93-like protein MFSD11 isoform X1. (448 aa)
xrcc4DNA repair protein XRCC4. (247 aa)
ptprcReceptor-type tyrosine-protein phosphatase C precursor. (1165 aa)
inipSOSS complex subunit C. (101 aa)
cdca7Cell division cycle-associated protein 7. (400 aa)
map3k20Mitogen-activated protein kinase kinase kinase MLT. (796 aa)
rnf168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (461 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (491 aa)
brca1Breast cancer type 1 susceptibility protein isoform X2. (1369 aa)
LOC108259721Alpha-crystallin B chain-like; Belongs to the small heat shock protein (HSP20) family. (172 aa)
tp53bp1Tumor suppressor p53-binding protein 1 isoform X3. (1750 aa)
mdm2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (473 aa)
rad9bCell cycle checkpoint control protein RAD9B isoform X1. (412 aa)
Your Current Organism:
Ictalurus punctatus
NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish
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