114 items (Ictalurus punctatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ppid	Peptidyl-prolyl cis-trans isomerase D. (421 aa)
	cops9	Myeloma overexpressed gene 2 protein-like protein. (189 aa)
	polh	DNA polymerase eta. (299 aa)
	opn4	Melanopsin. (392 aa)
	ENSIPUP00000024235	annotation not available (158 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (384 aa)
	rad51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (372 aa)
	chek2	Serine/threonine-protein kinase Chk2. (539 aa)
	bax	Apoptosis regulator BAX. (189 aa)
	atr	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2616 aa)
	LOC100304472	Red-sensitive opsin. (358 aa)
	nfatc4	Nuclear factor of activated T-cells, cytoplasmic 4. (643 aa)
	ENSIPUP00000021843	Secreted frizzled-related protein 2 like. (231 aa)
	tank	TRAF family member-associated NF-kappa-B activator isoform X2. (344 aa)
	LOC108270970	Apoptosis regulator BAX-like. (202 aa)
	zmpste24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (470 aa)
	LOC108280806	Growth arrest and DNA damage-inducible protein GADD45 alpha-like. (158 aa)
	lig4	DNA ligase. (909 aa)
	LOC108262800	Uncharacterized protein LOC108262800. (218 aa)
	LOC108264959	Protein crumbs homolog 1-like isoform X1. (1460 aa)
	brca2	Breast cancer type 2 susceptibility protein isoform X1. (2673 aa)
	polk	DNA polymerase kappa. (927 aa)
	LOC108277601	Alpha-crystallin B chain-like; Belongs to the small heat shock protein (HSP20) family. (167 aa)
	LOC108279275	CREB-binding protein-like isoform X2. (2381 aa)
	ercc1	DNA excision repair protein ERCC-1. (367 aa)
	LOC108267236	Protein crumbs homolog 1-like. (648 aa)
	elk1	ETS domain-containing protein Elk-1. (577 aa)
	LOC108279935	Microfibril-associated glycoprotein 4-like. (240 aa)
	LOC108272203	Growth arrest and DNA damage-inducible protein GADD45 alpha-like. (210 aa)
	LOC108258811	Microfibril-associated glycoprotein 4-like. (242 aa)
	LOC108258797	Microfibril-associated glycoprotein 4-like. (264 aa)
	LOC108259383	CREB-binding protein-like isoform X3. (2343 aa)
	LOC108258808	Microfibril-associated glycoprotein 4-like. (250 aa)
	LOC108258794	Microfibril-associated glycoprotein 4-like. (264 aa)
	LOC108258810	Microfibril-associated glycoprotein 4-like. (246 aa)
	LOC108258809	Microfibril-associated glycoprotein 4-like. (298 aa)
	LOC108258789	Microfibril-associated glycoprotein 4-like isoform X2. (253 aa)
	LOC108258806	Microfibril-associated glycoprotein 4-like. (251 aa)
	dhx36	ATP-dependent RNA helicase DHX36. (921 aa)
	cul4a	cullin-4A; Belongs to the cullin family. (741 aa)
	itgb6	Integrin beta; Belongs to the integrin beta chain family. (753 aa)
	LOC108255290	Deoxyribonuclease; Belongs to the DNase I family. (282 aa)
	LOC108255148	Deoxyribonuclease; Belongs to the DNase I family. (284 aa)
	atm	Non-specific serine/threonine protein kinase. (3076 aa)
	bard1	BRCA1-associated RING domain protein 1. (729 aa)
	tgfb3	Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
	rrh	Visual pigment-like receptor peropsin; Belongs to the G-protein coupled receptor 1 family. (335 aa)
	opn4m1	Mammal-like melanopsin 1 isoform X1. (561 aa)
	stk11	Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (439 aa)
	LOC108265970	Hyaluronidase. (435 aa)
	ENSIPUP00000010252	Melanocortin 1 receptor. (319 aa)
	LOC108280750	Transforming growth factor beta; Belongs to the TGF-beta family. (381 aa)
	LOC108276094	Mitogen-activated protein kinase. (359 aa)
	rad1	Cell cycle checkpoint protein RAD1 isoform X1. (291 aa)
	xrcc5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (726 aa)
	xpc	DNA repair protein complementing XP-C cells isoform X1. (896 aa)
	ddb1	DNA damage-binding protein 1. (1140 aa)
	LOC108267091	Aquaporin-1-like; Belongs to the MIP/aquaporin (TC 1.A.8) family. (261 aa)
	LOC108267089	Aquaporin-1-like; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
	LOC108267090	Aquaporin-1-like; Belongs to the MIP/aquaporin (TC 1.A.8) family. (265 aa)
	rad51ap1	RAD51-associated protein 1. (349 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (850 aa)
	cdca7l	Cell division cycle-associated 7-like protein. (473 aa)
	smpd1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (598 aa)
	ect2	Protein ECT2 isoform X7. (974 aa)
	LOC108279384	Transforming growth factor beta; Belongs to the TGF-beta family. (380 aa)
	pold3	DNA polymerase delta subunit 3 isoform X1. (471 aa)
	opn4m2	Mammal-like Melanopsin 2. (501 aa)
	wrn	Werner syndrome ATP-dependent helicase isoform X1. (1429 aa)
	ercc4	DNA repair endonuclease XPF. (899 aa)
	chek1	Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (466 aa)
	rhbdd1	Rhomboid-related protein 4 isoform X1. (328 aa)
	LOC108273944	Histone acetyltransferase p300-like isoform X6. (2631 aa)
	aurkb	Serine/threonine-protein kinase 12; Belongs to the protein kinase superfamily. (322 aa)
	mettl3	N6-adenosine-methyltransferase 70 kDa subunit; Belongs to the MT-A70-like family. (591 aa)
	blm	Bloom syndrome protein isoform X1. (1132 aa)
	tmem161a	Transmembrane protein 161A. (495 aa)
	xrcc6	X-ray repair cross-complementing protein 6. (609 aa)
	spidr	DNA repair-scaffolding protein isoform X2. (862 aa)
	rad9b	Cell cycle checkpoint control protein RAD9B isoform X1. (412 aa)
	impact	Protein IMPACT isoform X1. (323 aa)
	actr5	Actin-related protein 5; Belongs to the actin family. (619 aa)
	gpr88	Probable G-protein coupled receptor 88. (217 aa)
	LOC108262941	RPE-retinal G protein-coupled receptor-like. (287 aa)
	rho	Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity). (359 aa)
	LOC108254806	Mitogen-activated protein kinase 14A-like. (363 aa)
	pold1	DNA polymerase. (1066 aa)
	RHO	Rhodopsin. (365 aa)
	tp53bp1	Tumor suppressor p53-binding protein 1 isoform X3. (1750 aa)
	LOC108280996	Rhodopsin. (339 aa)
	LOC108272975	Histone acetyltransferase p300-like isoform X2. (2494 aa)
	LOC108259721	Alpha-crystallin B chain-like; Belongs to the small heat shock protein (HSP20) family. (172 aa)
	brca1	Breast cancer type 1 susceptibility protein isoform X2. (1369 aa)
	eif2s1	Eukaryotic Translation initiation factor 2 subunit 1. (315 aa)
	noc2l	Nucleolar complex protein 2 homolog. (745 aa)
	tp53inp1	Tumor protein p53-inducible nuclear protein 1. (242 aa)
	usp47	Ubiquitin carboxyl-terminal hydrolase 47 isoform X1; Belongs to the peptidase C19 family. (1337 aa)
	parp1	Poly [ADP-ribose] polymerase. (1018 aa)
	map3k20	Mitogen-activated protein kinase kinase kinase MLT. (796 aa)
	cdca7	Cell division cycle-associated protein 7. (400 aa)
	casp9	Caspase-9 isoform X2; Belongs to the peptidase C14A family. (432 aa)
	crb1	Protein crumbs homolog 1. (1184 aa)
	cul4b	cullin-4B; Belongs to the cullin family. (854 aa)
	FBXO4	F-box only protein 4-like. (157 aa)
	ino80	DNA helicase INO80. (1495 aa)
	LOC108257647	Opsin-5-like; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (350 aa)
	zbtb1	Zinc finger and BTB domain-containing protein 1. (672 aa)
	sirt1	NAD-dependent protein deacetylase sirtuin-1 isoform X3. (731 aa)
	Eif2ak4	Eukaryotic translation initiation factor 2 alpha kinase 4. (141 aa)
	LOC108265726	Mitogen-activated protein kinase. (361 aa)
	EIF2AK4	eIF-2-alpha kinase GCN2 isoform X1. (1396 aa)
	bmf	Bcl-2-modifying factor. (152 aa)
	opn3	Opsin-3. (405 aa)
	rhno1	RAD9, HUS1, RAD1-interacting nuclear orphan protein 1. (293 aa)

Your Current Organism:

Ictalurus punctatus

NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIF2AK4	Eif2ak4	ENSIPUP00000027171	ENSIPUP00000027206	eIF-2-alpha kinase GCN2 isoform X1.	Eukaryotic translation initiation factor 2 alpha kinase 4.	0.803
EIF2AK4	eif2s1	ENSIPUP00000027171	ENSIPUP00000031213	eIF-2-alpha kinase GCN2 isoform X1.	Eukaryotic Translation initiation factor 2 subunit 1.	0.922
EIF2AK4	impact	ENSIPUP00000027171	ENSIPUP00000037242	eIF-2-alpha kinase GCN2 isoform X1.	Protein IMPACT isoform X1.	0.412
ENSIPUP00000021843	LOC108277601	ENSIPUP00000021843	ENSIPUP00000018884	Secreted frizzled-related protein 2 like.	Alpha-crystallin B chain-like; Belongs to the small heat shock protein (HSP20) family.	0.499
Eif2ak4	EIF2AK4	ENSIPUP00000027206	ENSIPUP00000027171	Eukaryotic translation initiation factor 2 alpha kinase 4.	eIF-2-alpha kinase GCN2 isoform X1.	0.803
Eif2ak4	eif2s1	ENSIPUP00000027206	ENSIPUP00000031213	Eukaryotic translation initiation factor 2 alpha kinase 4.	Eukaryotic Translation initiation factor 2 subunit 1.	0.991
Eif2ak4	impact	ENSIPUP00000027206	ENSIPUP00000037242	Eukaryotic translation initiation factor 2 alpha kinase 4.	Protein IMPACT isoform X1.	0.412
LOC100304472	LOC108262941	ENSIPUP00000022810	ENSIPUP00000036733	Red-sensitive opsin.	RPE-retinal G protein-coupled receptor-like.	0.584
LOC100304472	LOC108280996	ENSIPUP00000022810	ENSIPUP00000033787	Red-sensitive opsin.	Rhodopsin.	0.439
LOC100304472	RHO	ENSIPUP00000022810	ENSIPUP00000034356	Red-sensitive opsin.	Rhodopsin.	0.439
LOC100304472	opn3	ENSIPUP00000022810	ENSIPUP00000026694	Red-sensitive opsin.	Opsin-3.	0.505
LOC100304472	rho	ENSIPUP00000022810	ENSIPUP00000036104	Red-sensitive opsin.	Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity).	0.439
LOC100304472	rrh	ENSIPUP00000022810	ENSIPUP00000011178	Red-sensitive opsin.	Visual pigment-like receptor peropsin; Belongs to the G-protein coupled receptor 1 family.	0.478
LOC108254806	elk1	ENSIPUP00000035734	ENSIPUP00000017425	Mitogen-activated protein kinase 14A-like.	ETS domain-containing protein Elk-1.	0.524
LOC108257647	LOC108262941	ENSIPUP00000027796	ENSIPUP00000036733	Opsin-5-like; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.	RPE-retinal G protein-coupled receptor-like.	0.489
LOC108257647	LOC108280996	ENSIPUP00000027796	ENSIPUP00000033787	Opsin-5-like; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.	Rhodopsin.	0.400
LOC108257647	RHO	ENSIPUP00000027796	ENSIPUP00000034356	Opsin-5-like; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.	Rhodopsin.	0.403
LOC108257647	opn3	ENSIPUP00000027796	ENSIPUP00000026694	Opsin-5-like; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.	Opsin-3.	0.498
LOC108257647	rho	ENSIPUP00000027796	ENSIPUP00000036104	Opsin-5-like; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.	Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity).	0.400
LOC108257647	rrh	ENSIPUP00000027796	ENSIPUP00000011178	Opsin-5-like; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.	Visual pigment-like receptor peropsin; Belongs to the G-protein coupled receptor 1 family.	0.455