56 items (Ictalurus punctatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	csde1	Cold shock domain-containing protein E1 isoform X6. (767 aa)
	wwp1	NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1. (995 aa)
	psenen	Presenilin enhancer, gamma-secretase subunit. (66 aa)
	LOC100304952	Gamma-secretase subunit Aph-1b. (260 aa)
	mxd4	Max dimerization protein 4. (214 aa)
	nrg1	Pro-neuregulin-1, membrane-bound isoform isoform X2. (597 aa)
	LOC108268830	Pro-neuregulin-2, membrane-bound isoform-like isoform X1. (708 aa)
	LOC108255075	Tyrosine-protein kinase. (533 aa)
	pik3ca	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	LOC108275608	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1054 aa)
	egf	Pro-epidermal growth factor. (936 aa)
	shc1	SHC-transforming protein 1 isoform X2. (494 aa)
	LOC108278992	Probetacellulin-like isoform X1. (177 aa)
	LOC108276113	E3 ubiquitin-protein ligase. (863 aa)
	LOC108274959	GTPase KRas isoform X1. (189 aa)
	LOC108271374	Gamma-secretase subunit Aph-1b. (258 aa)
	uba52	ubiquitin-60S ribosomal protein L40 isoform X1. (128 aa)
	LOC108258402	Receptor protein-tyrosine kinase. (730 aa)
	hras	GTPase HRas. (189 aa)
	LOC108258586	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (434 aa)
	LOC108258873	Receptor tyrosine-protein kinase erbB-4-like. (1315 aa)
	erbb4	Receptor protein-tyrosine kinase. (1389 aa)
	LOC108256494	Growth factor receptor-bound protein 2. (217 aa)
	LOC108269999	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (462 aa)
	nras	GTPase NRas. (195 aa)
	LOC108272460	Stathmin; Belongs to the stathmin family. (146 aa)
	stmn1	Stathmin; Belongs to the stathmin family. (144 aa)
	LOC108276756	arf-GAP with dual PH domain-containing protein 1-like isoform X1. (377 aa)
	yap1	Transcriptional coactivator YAP1 isoform X1. (444 aa)
	LOC108269204	Fibronectin type-III domain-containing protein 3A-like isoform X1. (1169 aa)
	rps27a	Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...] (156 aa)
	nedd4	E3 ubiquitin-protein ligase NEDD4. (900 aa)
	LOC108257071	arf-GAP with dual PH domain-containing protein 2-like isoform X1. (378 aa)
	wwox	WW domain-containing oxidoreductase isoform X1. (412 aa)
	pik3r1	Phosphatidylinositol 3-kinase regulatory subunit alpha. (728 aa)
	LOC108272920	arf-GAP with dual PH domain-containing protein 1-like isoform X1. (382 aa)
	LOC108273971	Pro-neuregulin-3, membrane-bound isoform-like isoform X2. (726 aa)
	LOC108268609	Proheparin-binding EGF-like growth factor. (235 aa)
	ncstn	Nicastrin. (721 aa)
	LOC108276199	Tyrosine-protein kinase. (543 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. (617 aa)
	erbb3	Receptor tyrosine-protein kinase erbB-3 isoform X2. (1415 aa)
	LOC108279147	Signal transducer and activator of transcription. (791 aa)
	nrg4	Pro-neuregulin-4, membrane-bound isoform isoform X1. (99 aa)
	LOC108271999	E3 ubiquitin-protein ligase. (847 aa)
	hbegf	Proheparin-binding EGF-like growth factor. (229 aa)
	LOC108271615	Receptor tyrosine-protein kinase erbB-3-like. (1309 aa)
	nrg2	Pro-neuregulin-2, membrane-bound isoform isoform X4. (737 aa)
	LOC108278233	Beta-crystallin B1-like; Belongs to the beta/gamma-crystallin family. (209 aa)
	LOC108258948	GTPase HRas-like isoform X2. (187 aa)
	grb2	Growth factor receptor-bound protein 2 isoform X1. (217 aa)
	LOC108259582	GTPase HRas. (189 aa)
	LOC108262175	Pro-neuregulin-3, membrane-bound isoform-like isoform X3. (347 aa)
	ENSIPUP00000032353	annotation not available (90 aa)
	LOC108273804	Signal transducer and activator of transcription. (784 aa)
	LOC108277863	Fibronectin type-III domain-containing protein 3a-like isoform X1. (1241 aa)

Your Current Organism:

Ictalurus punctatus

NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSIPUP00000032353	egf	ENSIPUP00000032353	ENSIPUP00000005158	annotation not available	Pro-epidermal growth factor.	0.445
ENSIPUP00000032353	nrg4	ENSIPUP00000032353	ENSIPUP00000031051	annotation not available	Pro-neuregulin-4, membrane-bound isoform isoform X1.	0.619
LOC100304952	LOC108258586	ENSIPUP00000002139	ENSIPUP00000009981	Gamma-secretase subunit Aph-1b.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.980
LOC100304952	LOC108269999	ENSIPUP00000002139	ENSIPUP00000013333	Gamma-secretase subunit Aph-1b.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.980
LOC100304952	LOC108271374	ENSIPUP00000002139	ENSIPUP00000006928	Gamma-secretase subunit Aph-1b.	Gamma-secretase subunit Aph-1b.	0.901
LOC100304952	ncstn	ENSIPUP00000002139	ENSIPUP00000027825	Gamma-secretase subunit Aph-1b.	Nicastrin.	0.993
LOC100304952	psenen	ENSIPUP00000002139	ENSIPUP00000001255	Gamma-secretase subunit Aph-1b.	Presenilin enhancer, gamma-secretase subunit.	0.966
LOC108255075	LOC108256494	ENSIPUP00000003408	ENSIPUP00000012121	Tyrosine-protein kinase.	Growth factor receptor-bound protein 2.	0.659
LOC108255075	LOC108258402	ENSIPUP00000003408	ENSIPUP00000008139	Tyrosine-protein kinase.	Receptor protein-tyrosine kinase.	0.462
LOC108255075	LOC108258873	ENSIPUP00000003408	ENSIPUP00000010147	Tyrosine-protein kinase.	Receptor tyrosine-protein kinase erbB-4-like.	0.462
LOC108255075	LOC108258948	ENSIPUP00000003408	ENSIPUP00000034432	Tyrosine-protein kinase.	GTPase HRas-like isoform X2.	0.433
LOC108255075	LOC108259582	ENSIPUP00000003408	ENSIPUP00000033492	Tyrosine-protein kinase.	GTPase HRas.	0.417
LOC108255075	LOC108271615	ENSIPUP00000003408	ENSIPUP00000034859	Tyrosine-protein kinase.	Receptor tyrosine-protein kinase erbB-3-like.	0.462
LOC108255075	LOC108273804	ENSIPUP00000003408	ENSIPUP00000031823	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.492
LOC108255075	LOC108274959	ENSIPUP00000003408	ENSIPUP00000006166	Tyrosine-protein kinase.	GTPase KRas isoform X1.	0.463
LOC108255075	LOC108275608	ENSIPUP00000003408	ENSIPUP00000004902	Tyrosine-protein kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.931
LOC108255075	LOC108276199	ENSIPUP00000003408	ENSIPUP00000028135	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.900
LOC108255075	LOC108278992	ENSIPUP00000003408	ENSIPUP00000005686	Tyrosine-protein kinase.	Probetacellulin-like isoform X1.	0.401
LOC108255075	LOC108279147	ENSIPUP00000003408	ENSIPUP00000030182	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.468
LOC108255075	csde1	ENSIPUP00000003408	ENSIPUP00000000460	Tyrosine-protein kinase.	Cold shock domain-containing protein E1 isoform X6.	0.403