STRINGSTRING
LOC108260489 LOC108260489 wrap53 wrap53 blm blm exd2 exd2 chtf18 chtf18 LOC108262486 LOC108262486 shq1 shq1 LOC108262497 LOC108262497 LOC108262536 LOC108262536 fen1 fen1 LOC108261379 LOC108261379 LOC108262589 LOC108262589 LOC108255684 LOC108255684 LOC108262596 LOC108262596 ENSIPUP00000002007 ENSIPUP00000002007 LOC108262617 LOC108262617 LOC108262621 LOC108262621 ENSIPUP00000002141 ENSIPUP00000002141 LOC108262673 LOC108262673 wrn wrn ENSIPUP00000002932 ENSIPUP00000002932 meiob meiob pold3 pold3 pold2 pold2 ankrd28 ankrd28 ANKRD52 ANKRD52 gar1 gar1 ENSIPUP00000005160 ENSIPUP00000005160 LOC108272432 LOC108272432 LOC108272324 LOC108272324 LOC108261415 LOC108261415 rfc1 rfc1 ctc1 ctc1 LOC108256911 LOC108256911 LOC108261983 LOC108261983 rpa1 rpa1 recql4 recql4 daxx daxx LOC108267930 LOC108267930 ENSIPUP00000009144 ENSIPUP00000009144 LOC108277171 LOC108277171 terf2ip terf2ip ENSIPUP00000011444 ENSIPUP00000011444 ENSIPUP00000011577 ENSIPUP00000011577 ENSIPUP00000011897 ENSIPUP00000011897 LOC108261425 LOC108261425 LOC108261488 LOC108261488 pola2 pola2 terf1 terf1 ENSIPUP00000012797 ENSIPUP00000012797 dscc1 dscc1 LOC108260105 LOC108260105 LOC108261379-2 LOC108261379-2 ENSIPUP00000013437 ENSIPUP00000013437 LOC108261415-2 LOC108261415-2 LOC108261690 LOC108261690 ENSIPUP00000013757 ENSIPUP00000013757 ccna1 ccna1 nop10 nop10 ruvbl2 ruvbl2 dkc1 dkc1 rfc3 rfc3 LOC108261712 LOC108261712 ENSIPUP00000016437 ENSIPUP00000016437 LOC108258592 LOC108258592 LOC108272412 LOC108272412 ENSIPUP00000017001 ENSIPUP00000017001 LOC108261860 LOC108261860 LOC108261861 LOC108261861 ENSIPUP00000017440 ENSIPUP00000017440 ankrd52 ankrd52 ENSIPUP00000017506 ENSIPUP00000017506 prim1 prim1 LOC108261901 LOC108261901 LOC108261899 LOC108261899 ENSIPUP00000017662 ENSIPUP00000017662 rfc4 rfc4 LOC108261415-3 LOC108261415-3 LOC108255684-2 LOC108255684-2 LOC108261964 LOC108261964 LOC108261379-3 LOC108261379-3 ppp6c ppp6c ENSIPUP00000018324 ENSIPUP00000018324 terf2 terf2 cdk2 cdk2 LOC108255684-3 LOC108255684-3 LOC108262131 LOC108262131 LOC108261415-4 LOC108261415-4 rtel1 rtel1 LOC108261415-5 LOC108261415-5 ENSIPUP00000018991 ENSIPUP00000018991 ENSIPUP00000019179 ENSIPUP00000019179 ankrd44 ankrd44 LOC108255684-4 LOC108255684-4 LOC108255684-5 LOC108255684-5 LOC108262397 LOC108262397 LOC108262407 LOC108262407 pif1 pif1 pold4 pold4 LOC108275203 LOC108275203 ten1 ten1 rpa2 rpa2 LOC108280318 LOC108280318 pola1 pola1 LOC108263846 LOC108263846 atrx atrx LOC108276547 LOC108276547 ccna2 ccna2 rpa3 rpa3 trub1 trub1 dna2 dna2 lig1 lig1 chtf8 chtf8 H2AZ1 H2AZ1 pot1 pot1 rfc5 rfc5 stn1 stn1 LOC108261097 LOC108261097 rcbtb1 rcbtb1 LOC108255943 LOC108255943 LOC108259650 LOC108259650 rcbtb2 rcbtb2 ENSIPUP00000033019 ENSIPUP00000033019 tert tert pold1 pold1 nhp2 nhp2 pcna pcna rfc2 rfc2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC108260489Histone H2B; Belongs to the histone H2B family. (117 aa)
wrap53Telomerase Cajal body protein 1. (541 aa)
blmBloom syndrome protein isoform X1. (1132 aa)
exd2Exonuclease 3'-5' domain-containing protein 2 isoform X1. (631 aa)
chtf18Chromosome transmission fidelity protein 18 homolog isoform X1. (952 aa)
LOC108262486Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (96 aa)
shq1Protein SHQ1 homolog. (576 aa)
LOC108262497Histone H4-like. (96 aa)
LOC108262536Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (100 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
LOC108261379Histone H2B 1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (124 aa)
LOC108262589Histone H4-like. (96 aa)
LOC108255684Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC108262596Histone H4-like. (96 aa)
ENSIPUP00000002007annotation not available (133 aa)
LOC108262617Histone H2B-like. (103 aa)
LOC108262621Histone H4-like. (75 aa)
ENSIPUP00000002141annotation not available (67 aa)
LOC108262673Histone H2B; Belongs to the histone H2B family. (124 aa)
wrnWerner syndrome ATP-dependent helicase isoform X1. (1429 aa)
ENSIPUP00000002932annotation not available (108 aa)
meiobMeiosis-specific with OB domain-containing protein. (466 aa)
pold3DNA polymerase delta subunit 3 isoform X1. (471 aa)
pold2DNA polymerase delta subunit 2. (467 aa)
ankrd28Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A. (1053 aa)
ANKRD52Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C-like. (1053 aa)
gar1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (211 aa)
ENSIPUP00000005160annotation not available (81 aa)
LOC108272432Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (102 aa)
LOC108272324Histone H2B; Belongs to the histone H2B family. (124 aa)
LOC108261415Histone H2A; Belongs to the histone H2A family. (128 aa)
rfc1Replication factor C subunit 1. (1129 aa)
ctc1CST complex subunit CTC1. (1240 aa)
LOC108256911Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like isoform X1. (1093 aa)
LOC108261983Histone H2B-like; Belongs to the histone H2B family. (88 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (606 aa)
recql4ATP-dependent DNA helicase Q4. (1490 aa)
daxxDeath domain-associated protein 6 isoform X1. (716 aa)
LOC108267930Uncharacterized protein LOC108267930 isoform X1. (604 aa)
ENSIPUP00000009144Histone H2B 3. (118 aa)
LOC108277171Histone H2A; Belongs to the histone H2A family. (128 aa)
terf2ipTelomeric repeat-binding factor 2-interacting protein 1 isoform X1. (536 aa)
ENSIPUP00000011444annotation not available (131 aa)
ENSIPUP00000011577DNA replication ATP-dependent helicase/nuclease DNA2-like. (96 aa)
ENSIPUP00000011897annotation not available (218 aa)
LOC108261425Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (104 aa)
LOC108261488Histone H2B; Belongs to the histone H2B family. (124 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (614 aa)
terf1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (404 aa)
ENSIPUP00000012797annotation not available (109 aa)
dscc1Sister chromatid cohesion protein DCC1. (481 aa)
LOC108260105Histone H2A; Belongs to the histone H2A family. (142 aa)
LOC108261379-2Histone H2B-like. (124 aa)
ENSIPUP00000013437annotation not available (145 aa)
LOC108261415-2Histone H2A. (128 aa)
LOC108261690Histone H4. (96 aa)
ENSIPUP00000013757annotation not available (100 aa)
ccna1cyclin-A1 isoform X2; Belongs to the cyclin family. (397 aa)
nop10H/ACA ribonucleoprotein complex subunit 3. (64 aa)
ruvbl2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
dkc1H/ACA ribonucleoprotein complex subunit 4 isoform X1. (596 aa)
rfc3Replication factor C subunit 3. (356 aa)
LOC108261712Histone H4-like. (81 aa)
ENSIPUP00000016437annotation not available (175 aa)
LOC108258592Histone H2A; Belongs to the histone H2A family. (132 aa)
LOC108272412Replication protein A 32 kDa subunit-like. (251 aa)
ENSIPUP00000017001annotation not available (67 aa)
LOC108261860Histone H4-like. (96 aa)
LOC108261861Histone H2B; Belongs to the histone H2B family. (125 aa)
ENSIPUP00000017440annotation not available (144 aa)
ankrd52Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C isoform X2. (1067 aa)
ENSIPUP00000017506annotation not available (134 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (442 aa)
LOC108261901Histone H4-like. (96 aa)
LOC108261899Histone H2B-like. (117 aa)
ENSIPUP00000017662annotation not available (150 aa)
rfc4Replication factor C subunit 4 isoform X1. (358 aa)
LOC108261415-3Histone H2A. (128 aa)
LOC108255684-2Histone H4. (103 aa)
LOC108261964Histone H2B; Belongs to the histone H2B family. (124 aa)
LOC108261379-3Histone H2B-like. (124 aa)
ppp6cSerine/threonine-protein phosphatase. (223 aa)
ENSIPUP00000018324annotation not available (150 aa)
terf2Telomeric repeat-binding factor 2 isoform X1. (649 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (301 aa)
LOC108255684-3Histone H4. (103 aa)
LOC108262131Histone H2B-like. (90 aa)
LOC108261415-4Histone H2A. (128 aa)
rtel1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1175 aa)
LOC108261415-5Histone H2A. (128 aa)
ENSIPUP00000018991annotation not available (96 aa)
ENSIPUP00000019179annotation not available (132 aa)
ankrd44Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B. (978 aa)
LOC108255684-4Histone H4. (103 aa)
LOC108255684-5Histone H4. (103 aa)
LOC108262397Histone H4-like. (96 aa)
LOC108262407Histone H2B; Belongs to the histone H2B family. (164 aa)
pif1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (654 aa)
pold4DNA polymerase delta subunit 4. (109 aa)
LOC108275203RNA-binding protein with multiple splicing isoform X2. (212 aa)
ten1CST complex subunit TEN1 isoform X1. (127 aa)
rpa2Replication protein A 32 kDa subunit. (294 aa)
LOC108280318LOW QUALITY PROTEIN: probable flap endonuclease 1 homolog. (325 aa)
pola1DNA polymerase. (1457 aa)
LOC108263846DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (515 aa)
atrxTranscriptional regulator ATRX isoform X2. (1976 aa)
LOC108276547Histone H2A; Belongs to the histone H2A family. (128 aa)
ccna2cyclin-A2; Belongs to the cyclin family. (423 aa)
rpa3Replication protein A 14 kDa subunit. (122 aa)
trub1Probable tRNA pseudouridine synthase 1. (302 aa)
dna2DNA replication ATP-dependent helicase/nuclease DNA2 isoform X4. (1343 aa)
lig1DNA ligase. (946 aa)
chtf8Chromosome transmission fidelity protein 8-like protein. (124 aa)
H2AZ1Histone H2A; Belongs to the histone H2A family. (132 aa)
pot1Protection of telomeres protein 1 isoform X1. (778 aa)
rfc5Replication factor C subunit 5. (339 aa)
stn1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (372 aa)
LOC108261097Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
rcbtb1RCC1 and BTB domain-containing protein 1. (531 aa)
LOC108255943Histone H2A.V. (131 aa)
LOC108259650RNA-binding protein with multiple splicing. (200 aa)
rcbtb2RCC1 and BTB domain-containing protein 2. (540 aa)
ENSIPUP00000033019annotation not available (92 aa)
tertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1097 aa)
pold1DNA polymerase. (1066 aa)
nhp2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (151 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (297 aa)
rfc2Replication factor C subunit 2. (357 aa)
Your Current Organism:
Ictalurus punctatus
NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish
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