65 items (Ictalurus punctatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC108255345	Arrestin domain-containing protein 3-like. (313 aa)
	panx1	Pannexin; Structural component of the gap junctions and the hemichannels. (409 aa)
	arrdc2	Arrestin domain-containing protein 2 isoform X2. (446 aa)
	bcl2l1	Bcl-2-like protein 1. (242 aa)
	LOC108273098	Caspase-8-like isoform X1; Belongs to the peptidase C14A family. (493 aa)
	ENSIPUP00000020603	annotation not available (660 aa)
	LOC108255838	Arrestin domain-containing protein 3. (414 aa)
	LOC108255998	Arrestin domain-containing protein 3-like. (462 aa)
	LOC108255660	Arrestin domain-containing protein 3-like. (446 aa)
	rps27a	Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...] (156 aa)
	tab3	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3. (554 aa)
	nod2	Nucleotide-binding oligomerization domain-containing protein 2. (981 aa)
	LOC108264559	Mitogen-activated protein kinase. (363 aa)
	cyld	Ubiquitin carboxyl-terminal hydrolase CYLD; Belongs to the peptidase C19 family. (768 aa)
	tab1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1. (495 aa)
	ube2n	Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
	LOC108273074	Thioredoxin-interacting protein-like. (397 aa)
	casp9	Caspase-9 isoform X2; Belongs to the peptidase C14A family. (432 aa)
	map3k20	Mitogen-activated protein kinase kinase kinase MLT. (796 aa)
	LOC108264382	Transmembrane protein 189-like. (283 aa)
	hsp90ab1	Heat shock protein HSP 90-beta isoform X1. (787 aa)
	LOC108276094	Mitogen-activated protein kinase. (359 aa)
	birc2	Baculoviral IAP repeat-containing protein 2 isoform X1. (616 aa)
	LOC108255212	Ubiquitin-conjugating enzyme E2 variant 1. (147 aa)
	txnip	Thioredoxin-interacting protein. (396 aa)
	LOC108276113	E3 ubiquitin-protein ligase. (863 aa)
	LOC108274084	Dual specificity mitogen-activated protein kinase kinase 6 isoform X1. (410 aa)
	bcl2	Apoptosis regulator Bcl-2. (204 aa)
	uba52	ubiquitin-60S ribosomal protein L40 isoform X1. (128 aa)
	ARRDC1	Arrestin domain-containing protein 1-like. (457 aa)
	birc7	Baculoviral IAP repeat-containing protein 7-like. (397 aa)
	LOC108271158	Receptor-interacting serine/threonine-protein kinase 2-like isoform X1. (531 aa)
	LOC108279513	Mitogen-activated protein kinase. (283 aa)
	tmem189	Transmembrane protein 189. (277 aa)
	LOC108279456	Mitogen-activated protein kinase. (361 aa)
	ub2v1	Ubiquitin-conjugating enzyme E2 variant 1. (147 aa)
	LOC108266082	Uncharacterized protein LOC108266082. (241 aa)
	LOC108271977	Ubiquitin carboxyl-terminal hydrolase CYLD-like; Belongs to the peptidase C19 family. (729 aa)
	LOC108266093	Thioredoxin domain-containing protein 3 homolog; Belongs to the NDK family. (644 aa)
	arrdc1	Arrestin domain-containing protein 1. (447 aa)
	LOC108260805	Ubiquitin carboxyl-terminal hydrolase CYLD-like isoform X1. (954 aa)
	LOC108263754	Thioredoxin; Belongs to the thioredoxin family. (107 aa)
	ripk2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (579 aa)
	ENSIPUP00000013382	annotation not available (226 aa)
	LOC108265726	Mitogen-activated protein kinase. (361 aa)
	nod1	Nucleotide-binding oligomerization domain-containing protein 1. (946 aa)
	casp2	LOW QUALITY PROTEIN: caspase-2; Belongs to the peptidase C14A family. (439 aa)
	LOC108266428	Uncharacterized protein LOC108266428 isoform X4. (111 aa)
	map3k7	Mitogen-activated protein kinase kinase kinase 7. (550 aa)
	LOC108266429	Uncharacterized protein LOC108266429 isoform X1. (114 aa)
	txn	Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] (107 aa)
	tab2	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (673 aa)
	LOC108267470	Apoptosis regulator Bcl-2-like. (204 aa)
	sugt1	Protein SGT1 homolog isoform X1. (326 aa)
	ikbkg	NF-kappa-B essential modulator. (568 aa)
	LOC108271999	E3 ubiquitin-protein ligase. (847 aa)
	pstpip2	Proline-serine-threonine phosphatase-interacting protein 2 isoform X2. (332 aa)
	LOC108254806	Mitogen-activated protein kinase 14A-like. (363 aa)
	ENSIPUP00000035701	annotation not available (158 aa)
	ENSIPUP00000035688	annotation not available (289 aa)
	LOC108259797	Apoptosis-associated speck-like protein containing a CARD. (101 aa)
	optn	Optineurin. (550 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (540 aa)
	LOC108265696	Mitogen-activated protein kinase. (389 aa)
	aamp	Angio-associated migratory Cell protein. (415 aa)

Your Current Organism:

Ictalurus punctatus

NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARRDC1	ENSIPUP00000013382	ENSIPUP00000007497	ENSIPUP00000013382	Arrestin domain-containing protein 1-like.	annotation not available	0.543
ARRDC1	LOC108263754	ENSIPUP00000007497	ENSIPUP00000013902	Arrestin domain-containing protein 1-like.	Thioredoxin; Belongs to the thioredoxin family.	0.674
ARRDC1	LOC108266093	ENSIPUP00000007497	ENSIPUP00000009421	Arrestin domain-containing protein 1-like.	Thioredoxin domain-containing protein 3 homolog; Belongs to the NDK family.	0.569
ARRDC1	LOC108271999	ENSIPUP00000007497	ENSIPUP00000036665	Arrestin domain-containing protein 1-like.	E3 ubiquitin-protein ligase.	0.434
ARRDC1	LOC108276113	ENSIPUP00000007497	ENSIPUP00000005773	Arrestin domain-containing protein 1-like.	E3 ubiquitin-protein ligase.	0.434
ARRDC1	txn	ENSIPUP00000007497	ENSIPUP00000010620	Arrestin domain-containing protein 1-like.	Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...]	0.674
ENSIPUP00000013382	ARRDC1	ENSIPUP00000013382	ENSIPUP00000007497	annotation not available	Arrestin domain-containing protein 1-like.	0.543
ENSIPUP00000013382	LOC108255345	ENSIPUP00000013382	ENSIPUP00000019731	annotation not available	Arrestin domain-containing protein 3-like.	0.543
ENSIPUP00000013382	LOC108255660	ENSIPUP00000013382	ENSIPUP00000020699	annotation not available	Arrestin domain-containing protein 3-like.	0.543
ENSIPUP00000013382	LOC108255838	ENSIPUP00000013382	ENSIPUP00000020635	annotation not available	Arrestin domain-containing protein 3.	0.543
ENSIPUP00000013382	LOC108255998	ENSIPUP00000013382	ENSIPUP00000020675	annotation not available	Arrestin domain-containing protein 3-like.	0.543
ENSIPUP00000013382	LOC108273074	ENSIPUP00000013382	ENSIPUP00000027605	annotation not available	Thioredoxin-interacting protein-like.	0.543
ENSIPUP00000013382	LOC108274084	ENSIPUP00000013382	ENSIPUP00000006048	annotation not available	Dual specificity mitogen-activated protein kinase kinase 6 isoform X1.	0.495
ENSIPUP00000013382	arrdc1	ENSIPUP00000013382	ENSIPUP00000015017	annotation not available	Arrestin domain-containing protein 1.	0.543
ENSIPUP00000013382	arrdc2	ENSIPUP00000013382	ENSIPUP00000020055	annotation not available	Arrestin domain-containing protein 2 isoform X2.	0.543
ENSIPUP00000013382	txnip	ENSIPUP00000013382	ENSIPUP00000005499	annotation not available	Thioredoxin-interacting protein.	0.543
LOC108254806	LOC108274084	ENSIPUP00000035734	ENSIPUP00000006048	Mitogen-activated protein kinase 14A-like.	Dual specificity mitogen-activated protein kinase kinase 6 isoform X1.	0.854
LOC108254806	map3k7	ENSIPUP00000035734	ENSIPUP00000015661	Mitogen-activated protein kinase 14A-like.	Mitogen-activated protein kinase kinase kinase 7.	0.411
LOC108254806	tab1	ENSIPUP00000035734	ENSIPUP00000025352	Mitogen-activated protein kinase 14A-like.	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1.	0.735
LOC108255212	LOC108264382	ENSIPUP00000003446	ENSIPUP00000029965	Ubiquitin-conjugating enzyme E2 variant 1.	Transmembrane protein 189-like.	0.598