STRINGSTRING
prim1 prim1 trub1 trub1 dna2 dna2 lig1 lig1 chtf8 chtf8 pot1 pot1 rfc5 rfc5 stn1 stn1 rcbtb1 rcbtb1 LOC108259650 LOC108259650 rcbtb2 rcbtb2 tert tert pold1 pold1 nhp2 nhp2 pcna pcna rfc2 rfc2 rpa3 rpa3 ccna2 ccna2 LOC108263846 LOC108263846 pola1 pola1 LOC108280318 LOC108280318 rpa2 rpa2 ten1 ten1 LOC108275203 LOC108275203 pold4 pold4 pif1 pif1 ankrd44 ankrd44 rtel1 rtel1 cdk2 cdk2 terf2 terf2 ppp6c ppp6c rfc4 rfc4 ankrd52 ankrd52 LOC108272412 LOC108272412 rfc3 rfc3 dkc1 dkc1 ruvbl2 ruvbl2 nop10 nop10 ccna1 ccna1 dscc1 dscc1 terf1 terf1 pola2 pola2 ENSIPUP00000011577 ENSIPUP00000011577 terf2ip terf2ip LOC108267930 LOC108267930 recql4 recql4 rpa1 rpa1 LOC108256911 LOC108256911 ctc1 ctc1 rfc1 rfc1 gar1 gar1 ANKRD52 ANKRD52 ankrd28 ankrd28 pold2 pold2 pold3 pold3 meiob meiob wrn wrn fen1 fen1 shq1 shq1 chtf18 chtf18 exd2 exd2 blm blm wrap53 wrap53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (442 aa)
trub1Probable tRNA pseudouridine synthase 1. (302 aa)
dna2DNA replication ATP-dependent helicase/nuclease DNA2 isoform X4. (1343 aa)
lig1DNA ligase. (946 aa)
chtf8Chromosome transmission fidelity protein 8-like protein. (124 aa)
pot1Protection of telomeres protein 1 isoform X1. (778 aa)
rfc5Replication factor C subunit 5. (339 aa)
stn1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (372 aa)
rcbtb1RCC1 and BTB domain-containing protein 1. (531 aa)
LOC108259650RNA-binding protein with multiple splicing. (200 aa)
rcbtb2RCC1 and BTB domain-containing protein 2. (540 aa)
tertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1097 aa)
pold1DNA polymerase. (1066 aa)
nhp2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (151 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (297 aa)
rfc2Replication factor C subunit 2. (357 aa)
rpa3Replication protein A 14 kDa subunit. (122 aa)
ccna2cyclin-A2; Belongs to the cyclin family. (423 aa)
LOC108263846DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (515 aa)
pola1DNA polymerase. (1457 aa)
LOC108280318LOW QUALITY PROTEIN: probable flap endonuclease 1 homolog. (325 aa)
rpa2Replication protein A 32 kDa subunit. (294 aa)
ten1CST complex subunit TEN1 isoform X1. (127 aa)
LOC108275203RNA-binding protein with multiple splicing isoform X2. (212 aa)
pold4DNA polymerase delta subunit 4. (109 aa)
pif1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (654 aa)
ankrd44Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B. (978 aa)
rtel1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1175 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (301 aa)
terf2Telomeric repeat-binding factor 2 isoform X1. (649 aa)
ppp6cSerine/threonine-protein phosphatase. (223 aa)
rfc4Replication factor C subunit 4 isoform X1. (358 aa)
ankrd52Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C isoform X2. (1067 aa)
LOC108272412Replication protein A 32 kDa subunit-like. (251 aa)
rfc3Replication factor C subunit 3. (356 aa)
dkc1H/ACA ribonucleoprotein complex subunit 4 isoform X1. (596 aa)
ruvbl2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
nop10H/ACA ribonucleoprotein complex subunit 3. (64 aa)
ccna1cyclin-A1 isoform X2; Belongs to the cyclin family. (397 aa)
dscc1Sister chromatid cohesion protein DCC1. (481 aa)
terf1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (404 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (614 aa)
ENSIPUP00000011577DNA replication ATP-dependent helicase/nuclease DNA2-like. (96 aa)
terf2ipTelomeric repeat-binding factor 2-interacting protein 1 isoform X1. (536 aa)
LOC108267930Uncharacterized protein LOC108267930 isoform X1. (604 aa)
recql4ATP-dependent DNA helicase Q4. (1490 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (606 aa)
LOC108256911Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like isoform X1. (1093 aa)
ctc1CST complex subunit CTC1. (1240 aa)
rfc1Replication factor C subunit 1. (1129 aa)
gar1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (211 aa)
ANKRD52Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C-like. (1053 aa)
ankrd28Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A. (1053 aa)
pold2DNA polymerase delta subunit 2. (467 aa)
pold3DNA polymerase delta subunit 3 isoform X1. (471 aa)
meiobMeiosis-specific with OB domain-containing protein. (466 aa)
wrnWerner syndrome ATP-dependent helicase isoform X1. (1429 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
shq1Protein SHQ1 homolog. (576 aa)
chtf18Chromosome transmission fidelity protein 18 homolog isoform X1. (952 aa)
exd2Exonuclease 3'-5' domain-containing protein 2 isoform X1. (631 aa)
blmBloom syndrome protein isoform X1. (1132 aa)
wrap53Telomerase Cajal body protein 1. (541 aa)
Your Current Organism:
Ictalurus punctatus
NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish
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