17 items (Ictalurus punctatus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	uba52	ubiquitin-60S ribosomal protein L40 isoform X1. (128 aa)
	LOC108271158	Receptor-interacting serine/threonine-protein kinase 2-like isoform X1. (531 aa)
	ripk2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (579 aa)
	myd88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (279 aa)
	nfkbia	NF-kappa-B inhibitor alpha. (320 aa)
	sqstm1	Sequestosome-1. (460 aa)
	irak1	Interleukin-1 receptor-associated kinase 1 isoform X4. (718 aa)
	prkci	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (509 aa)
	LOC108276493	Neurotrophin-7-like; Belongs to the NGF-beta family. (211 aa)
	LOC108258222	NF-kappa-B inhibitor alpha-like. (308 aa)
	rps27a	Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...] (156 aa)
	LOC108273578	Tumor necrosis factor receptor superfamily member 16-like. (409 aa)
	gsap	Gamma-secretase-activating protein. (877 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (540 aa)
	ngf	Beta-nerve growth factor; Belongs to the NGF-beta family. (197 aa)
	ngfr	Tumor necrosis factor receptor superfamily member 16 isoform X1. (378 aa)
	ikbkb	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (776 aa)

Your Current Organism:

Ictalurus punctatus

NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC108258222	LOC108276493	ENSIPUP00000022153	ENSIPUP00000020793	NF-kappa-B inhibitor alpha-like.	Neurotrophin-7-like; Belongs to the NGF-beta family.	0.447
LOC108258222	ikbkb	ENSIPUP00000022153	ENSIPUP00000037211	NF-kappa-B inhibitor alpha-like.	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1.	0.994
LOC108258222	irak1	ENSIPUP00000022153	ENSIPUP00000019227	NF-kappa-B inhibitor alpha-like.	Interleukin-1 receptor-associated kinase 1 isoform X4.	0.586
LOC108258222	myd88	ENSIPUP00000022153	ENSIPUP00000018002	NF-kappa-B inhibitor alpha-like.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.591
LOC108258222	nfkbia	ENSIPUP00000022153	ENSIPUP00000018449	NF-kappa-B inhibitor alpha-like.	NF-kappa-B inhibitor alpha.	0.902
LOC108258222	ngfr	ENSIPUP00000022153	ENSIPUP00000036359	NF-kappa-B inhibitor alpha-like.	Tumor necrosis factor receptor superfamily member 16 isoform X1.	0.411
LOC108258222	rps27a	ENSIPUP00000022153	ENSIPUP00000022626	NF-kappa-B inhibitor alpha-like.	Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...]	0.917
LOC108258222	sqstm1	ENSIPUP00000022153	ENSIPUP00000019226	NF-kappa-B inhibitor alpha-like.	Sequestosome-1.	0.598
LOC108258222	traf6	ENSIPUP00000022153	ENSIPUP00000032978	NF-kappa-B inhibitor alpha-like.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.720
LOC108258222	uba52	ENSIPUP00000022153	ENSIPUP00000007381	NF-kappa-B inhibitor alpha-like.	ubiquitin-60S ribosomal protein L40 isoform X1.	0.874
LOC108271158	LOC108276493	ENSIPUP00000007939	ENSIPUP00000020793	Receptor-interacting serine/threonine-protein kinase 2-like isoform X1.	Neurotrophin-7-like; Belongs to the NGF-beta family.	0.491
LOC108271158	ikbkb	ENSIPUP00000007939	ENSIPUP00000037211	Receptor-interacting serine/threonine-protein kinase 2-like isoform X1.	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1.	0.470
LOC108271158	irak1	ENSIPUP00000007939	ENSIPUP00000019227	Receptor-interacting serine/threonine-protein kinase 2-like isoform X1.	Interleukin-1 receptor-associated kinase 1 isoform X4.	0.561
LOC108271158	myd88	ENSIPUP00000007939	ENSIPUP00000018002	Receptor-interacting serine/threonine-protein kinase 2-like isoform X1.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.537
LOC108271158	ngfr	ENSIPUP00000007939	ENSIPUP00000036359	Receptor-interacting serine/threonine-protein kinase 2-like isoform X1.	Tumor necrosis factor receptor superfamily member 16 isoform X1.	0.859
LOC108271158	ripk2	ENSIPUP00000007939	ENSIPUP00000013628	Receptor-interacting serine/threonine-protein kinase 2-like isoform X1.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.900
LOC108271158	rps27a	ENSIPUP00000007939	ENSIPUP00000022626	Receptor-interacting serine/threonine-protein kinase 2-like isoform X1.	Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...]	0.491
LOC108271158	traf6	ENSIPUP00000007939	ENSIPUP00000032978	Receptor-interacting serine/threonine-protein kinase 2-like isoform X1.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.978
LOC108271158	uba52	ENSIPUP00000007939	ENSIPUP00000007381	Receptor-interacting serine/threonine-protein kinase 2-like isoform X1.	ubiquitin-60S ribosomal protein L40 isoform X1.	0.498
LOC108273578	LOC108276493	ENSIPUP00000025664	ENSIPUP00000020793	Tumor necrosis factor receptor superfamily member 16-like.	Neurotrophin-7-like; Belongs to the NGF-beta family.	0.980