STRINGSTRING
LOC108279384 LOC108279384 LOC108274807 LOC108274807 stub1 stub1 uba52 uba52 LOC108267967 LOC108267967 LOC108280750 LOC108280750 LOC108254810 LOC108254810 LOC108266333 LOC108266333 ldlrad4 ldlrad4 LOC108280666 LOC108280666 LOC108274338 LOC108274338 smad7 smad7 SMURF2 SMURF2 rps27a rps27a tgfbr2 tgfbr2 LOC108259569 LOC108259569 LOC108264458 LOC108264458 strap strap smad2 smad2 tgfbr1 tgfbr1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC108279384Transforming growth factor beta; Belongs to the TGF-beta family. (380 aa)
LOC108274807Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (542 aa)
stub1E3 ubiquitin-protein ligase CHIP isoform X2. (286 aa)
uba52ubiquitin-60S ribosomal protein L40 isoform X1. (128 aa)
LOC108267967Low-density lipoprotein receptor class A domain-containing protein 4-like isoform X1. (306 aa)
LOC108280750Transforming growth factor beta; Belongs to the TGF-beta family. (381 aa)
LOC108254810E3 ubiquitin-protein ligase. (764 aa)
LOC108266333Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (581 aa)
ldlrad4Low-density lipoprotein receptor class A domain-containing protein 4. (218 aa)
LOC108280666BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (256 aa)
LOC108274338BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (256 aa)
smad7Mothers against decapentaplegic homolog. (386 aa)
SMURF2E3 ubiquitin-protein ligase. (727 aa)
rps27aUbiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...] (156 aa)
tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (572 aa)
LOC108259569Mothers against decapentaplegic homolog. (425 aa)
LOC108264458Mothers against decapentaplegic homolog. (424 aa)
strapSerine-threonine kinase receptor-associated protein. (329 aa)
smad2Mothers against decapentaplegic homolog. (467 aa)
tgfbr1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (496 aa)
Your Current Organism:
Ictalurus punctatus
NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish
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