STRINGSTRING
LOC108263894 LOC108263894 ltbp4 ltbp4 LOC108279384 LOC108279384 itgav itgav fbn2 fbn2 furin furin LOC108274807 LOC108274807 itgb8 itgb8 itgb3 itgb3 LOC108267606 LOC108267606 stub1 stub1 smad4 smad4 uba52 uba52 kxd1 kxd1 LOC108267967 LOC108267967 LOC108280750 LOC108280750 nedd8 nedd8 LOC108261142 LOC108261142 tgfb3 tgfb3 LOC108254810 LOC108254810 LOC108261434 LOC108261434 ltbp2 ltbp2 fkb1b fkb1b LOC108266333 LOC108266333 itgb6 itgb6 ldlrad4 ldlrad4 LOC108280666 LOC108280666 cbl cbl LOC108274338 LOC108274338 ube2m ube2m LOC108269225 LOC108269225 smad7 smad7 LOC108280307 LOC108280307 SMURF2 SMURF2 rps27a rps27a tgfb2 tgfb2 tgfbr2 tgfbr2 ltbp1 ltbp1 LOC108273360 LOC108273360 FBN1 FBN1 fkbp1b fkbp1b LOC108259569 LOC108259569 ltbp3 ltbp3 LOC108264458 LOC108264458 itgb5 itgb5 itga8 itga8 LOC108268908 LOC108268908 LOC108270701 LOC108270701 LOC108255640 LOC108255640 strap strap LOC108279461 LOC108279461 smad2 smad2 tgfbr1 tgfbr1 fbn3 fbn3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC108263894Uncharacterized protein LOC108263894. (474 aa)
ltbp4Latent-transforming growth factor beta-binding protein 4 isoform X1. (1822 aa)
LOC108279384Transforming growth factor beta; Belongs to the TGF-beta family. (380 aa)
itgavIntegrin alpha-V; Belongs to the integrin alpha chain family. (1043 aa)
fbn2Fibrillin-2. (2513 aa)
furinFurin-1; Belongs to the peptidase S8 family. (828 aa)
LOC108274807Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (542 aa)
itgb8Integrin beta; Belongs to the integrin beta chain family. (791 aa)
itgb3Integrin beta; Belongs to the integrin beta chain family. (793 aa)
LOC108267606Mothers against decapentaplegic homolog. (574 aa)
stub1E3 ubiquitin-protein ligase CHIP isoform X2. (286 aa)
smad4Mothers against decapentaplegic homolog. (546 aa)
uba52ubiquitin-60S ribosomal protein L40 isoform X1. (128 aa)
kxd1kxDL motif-containing protein 1 isoform X2. (187 aa)
LOC108267967Low-density lipoprotein receptor class A domain-containing protein 4-like isoform X1. (306 aa)
LOC108280750Transforming growth factor beta; Belongs to the TGF-beta family. (381 aa)
nedd8NEDD8. (89 aa)
LOC108261142Neurogenic locus notch homolog protein 1-like isoform X4. (330 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
LOC108254810E3 ubiquitin-protein ligase. (764 aa)
LOC108261434Fibrillin-1-like. (191 aa)
ltbp2Latent transforming growth factor beta binding protein 2. (1216 aa)
fkb1bPeptidylprolyl isomerase. (108 aa)
LOC108266333Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (581 aa)
itgb6Integrin beta; Belongs to the integrin beta chain family. (753 aa)
ldlrad4Low-density lipoprotein receptor class A domain-containing protein 4. (218 aa)
LOC108280666BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (256 aa)
cblE3 ubiquitin-protein ligase CBL. (911 aa)
LOC108274338BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (256 aa)
ube2mNEDD8-conjugating enzyme Ubc12; Belongs to the ubiquitin-conjugating enzyme family. (185 aa)
LOC108269225E3 ubiquitin-protein ligase CBL-like isoform X1. (625 aa)
smad7Mothers against decapentaplegic homolog. (386 aa)
LOC108280307Zinc finger FYVE domain-containing protein 9-like isoform X1. (1183 aa)
SMURF2E3 ubiquitin-protein ligase. (727 aa)
rps27aUbiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...] (156 aa)
tgfb2Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (572 aa)
ltbp1Latent-transforming growth factor beta-binding protein 1. (1475 aa)
LOC108273360Mothers against decapentaplegic homolog. (561 aa)
FBN1Fibrillin-1. (1879 aa)
fkbp1bPeptidylprolyl isomerase. (137 aa)
LOC108259569Mothers against decapentaplegic homolog. (425 aa)
ltbp3Latent-transforming growth factor beta-binding protein 3 isoform X1. (1257 aa)
LOC108264458Mothers against decapentaplegic homolog. (424 aa)
itgb5Integrin beta; Belongs to the integrin beta chain family. (804 aa)
itga8Integrin alpha-8; Belongs to the integrin alpha chain family. (1055 aa)
LOC108268908Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
LOC108270701Furin-1-like; Belongs to the peptidase S8 family. (812 aa)
LOC108255640Mothers against decapentaplegic homolog. (523 aa)
strapSerine-threonine kinase receptor-associated protein. (329 aa)
LOC108279461Integrin beta; Belongs to the integrin beta chain family. (786 aa)
smad2Mothers against decapentaplegic homolog. (467 aa)
tgfbr1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (496 aa)
fbn3Fibrillin-3 isoform X1. (2754 aa)
Your Current Organism:
Ictalurus punctatus
NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.