STRINGSTRING
LOC108256206 LOC108256206 fgf2 fgf2 csde1 csde1 ppp2cb ppp2cb LOC108255075 LOC108255075 pik3ca pik3ca LOC108275608 LOC108275608 shc1 shc1 LOC108274959 LOC108274959 fgf23 fgf23 uba52 uba52 LOC108266192 LOC108266192 hras hras fgf17 fgf17 ppp2ca ppp2ca LOC108263592 LOC108263592 frs2 frs2 LOC108256494 LOC108256494 LOC108274431 LOC108274431 fgf5 fgf5 LOC108259026 LOC108259026 fgf1 fgf1 nras nras fgf1-2 fgf1-2 cbl cbl LOC108277698 LOC108277698 LOC108269225 LOC108269225 mknk1 mknk1 mknk2 mknk2 fgf4 fgf4 LOC108269204 LOC108269204 rps27a rps27a fgf16 fgf16 galnt3 galnt3 plcg1 plcg1 LOC108278138 LOC108278138 ENSIPUP00000024252 ENSIPUP00000024252 frs3 frs3 pik3r1 pik3r1 braf braf LOC108276199 LOC108276199 LOC108268415 LOC108268415 mapk1 mapk1 LOC108277863 LOC108277863 LOC108268489 LOC108268489 LOC108276041 LOC108276041 LOC108259582 LOC108259582 LOC108260120 LOC108260120 fgf20 fgf20 grb2 grb2 LOC108258948 LOC108258948 LOC108262899 LOC108262899
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC108256206Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (151 aa)
csde1Cold shock domain-containing protein E1 isoform X6. (767 aa)
ppp2cbSerine/threonine-protein phosphatase. (309 aa)
LOC108255075Tyrosine-protein kinase. (533 aa)
pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
LOC108275608Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1054 aa)
shc1SHC-transforming protein 1 isoform X2. (494 aa)
LOC108274959GTPase KRas isoform X1. (189 aa)
fgf23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (254 aa)
uba52ubiquitin-60S ribosomal protein L40 isoform X1. (128 aa)
LOC108266192Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (69 aa)
hrasGTPase HRas. (189 aa)
fgf17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
ppp2caSerine/threonine-protein phosphatase. (309 aa)
LOC108263592Fibroblast growth factor receptor. (820 aa)
frs2Fibroblast growth factor receptor substrate 2 isoform X1. (514 aa)
LOC108256494Growth factor receptor-bound protein 2. (217 aa)
LOC108274431Fibroblast growth factor 18-like isoform X1; Belongs to the heparin-binding growth factors family. (208 aa)
fgf5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
LOC108259026Protein sprouty homolog 2-like. (333 aa)
fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
nrasGTPase NRas. (195 aa)
fgf1-2Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (154 aa)
cblE3 ubiquitin-protein ligase CBL. (911 aa)
LOC108277698Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform-like. (589 aa)
LOC108269225E3 ubiquitin-protein ligase CBL-like isoform X1. (625 aa)
mknk1MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1; Belongs to the protein kinase superfamily. (459 aa)
mknk2MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. (476 aa)
fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (185 aa)
LOC108269204Fibronectin type-III domain-containing protein 3A-like isoform X1. (1169 aa)
rps27aUbiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...] (156 aa)
fgf16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
galnt3Polypeptide N-acetylgalactosaminyltransferase. (624 aa)
plcg11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1306 aa)
LOC108278138MAP kinase-interacting serine/threonine-protein kinase 2-like isoform X1; Belongs to the protein kinase superfamily. (126 aa)
ENSIPUP00000024252annotation not available (77 aa)
frs3Fibroblast growth factor receptor substrate 3. (622 aa)
pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha. (728 aa)
brafSerine/threonine-protein kinase B-raf. (782 aa)
LOC108276199Tyrosine-protein kinase. (543 aa)
LOC108268415Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa)
LOC108277863Fibronectin type-III domain-containing protein 3a-like isoform X1. (1241 aa)
LOC108268489Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa)
LOC108276041Polypeptide N-acetylgalactosaminyltransferase. (613 aa)
LOC108259582GTPase HRas. (189 aa)
LOC108260120Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (589 aa)
fgf20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa)
grb2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
LOC108258948GTPase HRas-like isoform X2. (187 aa)
LOC108262899Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (197 aa)
Your Current Organism:
Ictalurus punctatus
NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.