Your Input: | |
| | pole | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2286 aa) |
| | nbn | Nibrin. (831 aa) |
| | ENSIPUP00000005160 | annotation not available (81 aa) |
| | LOC108272432 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (102 aa) |
| | LOC108272324 | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | rfc1 | Replication factor C subunit 1. (1129 aa) |
| | abraxas1 | BRCA1-A complex subunit Abraxas. (393 aa) |
| | eme1 | Crossover junction endonuclease EME1. (516 aa) |
| | LOC108261983 | Histone H2B-like; Belongs to the histone H2B family. (88 aa) |
| | cdca7l | Cell division cycle-associated 7-like protein. (473 aa) |
| | rad52 | DNA repair protein RAD52 homolog isoform X1. (456 aa) |
| | rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (606 aa) |
| | recql4 | ATP-dependent DNA helicase Q4. (1490 aa) |
| | topbp1 | DNA topoisomerase 2-binding protein 1 isoform X7. (1561 aa) |
| | LOC108271937 | Crossover junction endonuclease EME1-like. (431 aa) |
| | rad51ap1 | RAD51-associated protein 1. (349 aa) |
| | uba52 | ubiquitin-60S ribosomal protein L40 isoform X1. (128 aa) |
| | mdc1 | Mediator of DNA damage checkpoint protein 1 isoform X2. (1909 aa) |
| | kxd1 | kxDL motif-containing protein 1 isoform X2. (187 aa) |
| | ENSIPUP00000009144 | Histone H2B 3. (118 aa) |
| | LOC108277171 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | rad1 | Cell cycle checkpoint protein RAD1 isoform X1. (291 aa) |
| | uimc1 | BRCA1-A complex subunit RAP80 isoform X1. (960 aa) |
| | LOC108276138 | Serine/threonine-protein phosphatase 4 regulatory subunit 2-A-like isoform X1. (418 aa) |
| | nsd2 | Histone-lysine N-methyltransferase NSD2 isoform X2. (1480 aa) |
| | babam1 | BRISC and BRCA1-A complex member 1. (369 aa) |
| | pole4 | DNA polymerase epsilon subunit 4. (125 aa) |
| | pole3 | DNA polymerase epsilon subunit 3. (149 aa) |
| | ENSIPUP00000011444 | annotation not available (131 aa) |
| | ENSIPUP00000011577 | DNA replication ATP-dependent helicase/nuclease DNA2-like. (96 aa) |
| | ENSIPUP00000011897 | annotation not available (218 aa) |
| | LOC108261425 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (104 aa) |
| | atm | Non-specific serine/threonine protein kinase. (3076 aa) |
| | LOC108261488 | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | ENSIPUP00000012797 | annotation not available (109 aa) |
| | rmi1 | recQ-mediated genome instability protein 1. (649 aa) |
| | LOC108261379-2 | Histone H2B-like. (124 aa) |
| | ENSIPUP00000013437 | annotation not available (145 aa) |
| | LOC108261690 | Histone H4. (96 aa) |
| | ENSIPUP00000013757 | annotation not available (100 aa) |
| | ccna1 | cyclin-A1 isoform X2; Belongs to the cyclin family. (397 aa) |
| | babam2 | BRCA1-A complex subunit BRE. (386 aa) |
| | rfc3 | Replication factor C subunit 3. (356 aa) |
| | brcc3 | Lys-63-specific deubiquitinase BRCC36 isoform X1. (260 aa) |
| | LOC108261712 | Histone H4-like. (81 aa) |
| | ENSIPUP00000016196 | annotation not available (490 aa) |
| | ENSIPUP00000016437 | annotation not available (175 aa) |
| | atrip | ATR-interacting protein. (754 aa) |
| | LOC108258592 | Histone H2A; Belongs to the histone H2A family. (132 aa) |
| | slx4 | Structure-specific endonuclease subunit SLX4. (1195 aa) |
| | LOC108272412 | Replication protein A 32 kDa subunit-like. (251 aa) |
| | ENSIPUP00000017001 | annotation not available (67 aa) |
| | LOC108261860 | Histone H4-like. (96 aa) |
| | LOC108261861 | Histone H2B; Belongs to the histone H2B family. (125 aa) |
| | ENSIPUP00000017440 | annotation not available (144 aa) |
| | LOC108261901 | Histone H4-like. (96 aa) |
| | LOC108261899 | Histone H2B-like. (117 aa) |
| | ENSIPUP00000017662 | annotation not available (150 aa) |
| | rfc4 | Replication factor C subunit 4 isoform X1. (358 aa) |
| | LOC108255684-2 | Histone H4. (103 aa) |
| | LOC108261964 | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | LOC108261379-3 | Histone H2B-like. (124 aa) |
| | sirt7 | NAD-dependent protein deacetylase sirtuin-7. (411 aa) |
| | tdrd3 | Tudor domain-containing protein 3. (801 aa) |
| | ENSIPUP00000018324 | annotation not available (150 aa) |
| | cdk2 | Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (301 aa) |
| | timeless | Protein timeless homolog. (1245 aa) |
| | rad50 | DNA repair protein RAD50 isoform X1. (1311 aa) |
| | LOC108255684-3 | Histone H4. (103 aa) |
| | LOC108262131 | Histone H2B-like. (90 aa) |
| | ENSIPUP00000018991 | annotation not available (96 aa) |
| | ENSIPUP00000019080 | annotation not available (285 aa) |
| | polk | DNA polymerase kappa. (927 aa) |
| | brca2 | Breast cancer type 2 susceptibility protein isoform X1. (2673 aa) |
| | LOC108255684-4 | Histone H4. (103 aa) |
| | LOC108255684-5 | Histone H4. (103 aa) |
| | LOC108262397 | Histone H4-like. (96 aa) |
| | LOC108262407 | Histone H2B; Belongs to the histone H2B family. (164 aa) |
| | pold4 | DNA polymerase delta subunit 4. (109 aa) |
| | kat5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (435 aa) |
| | rpa2 | Replication protein A 32 kDa subunit. (294 aa) |
| | rps27a | Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...] (156 aa) |
| | abl1 | Tyrosine-protein kinase. (1089 aa) |
| | atr | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2616 aa) |
| | rad51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (372 aa) |
| | rad9a | Cell cycle checkpoint control protein; Belongs to the rad9 family. (384 aa) |
| | ccna2 | cyclin-A2; Belongs to the cyclin family. (423 aa) |
| | pole2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa) |
| | ppp4c | Serine/threonine-protein phosphatase. (307 aa) |
| | polh | DNA polymerase eta. (299 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (999 aa) |
| | gen1 | Flap endonuclease GEN homolog 1 isoform X2. (893 aa) |
| | ube2n | Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | rpa3 | Replication protein A 14 kDa subunit. (122 aa) |
| | ankrd12 | Ankyrin repeat domain-containing protein 12 isoform X2. (2035 aa) |
| | rhno1 | RAD9, HUS1, RAD1-interacting nuclear orphan protein 1. (293 aa) |
| | sirt6 | NAD-dependent protein deacetylase sirtuin-6 isoform X1. (386 aa) |
| | dna2 | DNA replication ATP-dependent helicase/nuclease DNA2 isoform X4. (1343 aa) |
| | slf1 | SMC5-SMC6 complex localization factor protein 1 isoform X1. (891 aa) |
| | exo1 | Exonuclease 1 isoform X1. (769 aa) |
| | LOC108255359 | Uncharacterized protein LOC108255359 isoform X2. (1394 aa) |
| | hus1 | Checkpoint protein; Belongs to the HUS1 family. (281 aa) |
| | LOC108273059 | Small ubiquitin-related modifier. (94 aa) |
| | rad51c | DNA repair protein RAD51 homolog 3 isoform X1. (361 aa) |
| | rmi2 | RecQ-mediated Genome instability protein 2. (146 aa) |
| | LOC108267068 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (263 aa) |
| | LOC108257257 | SUMO-conjugating enzyme UBC9-B. (157 aa) |
| | tipin | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (297 aa) |
| | rfc5 | Replication factor C subunit 5. (339 aa) |
| | cdca7 | Cell division cycle-associated protein 7. (400 aa) |
| | mus81 | Crossover junction endonuclease MUS81. (627 aa) |
| | LOC108261097 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | rnf169 | E3 ubiquitin-protein ligase RNF169. (619 aa) |
| | rcbtb1 | RCC1 and BTB domain-containing protein 1. (531 aa) |
| | rnf168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (461 aa) |
| | rcbtb2 | RCC1 and BTB domain-containing protein 2. (540 aa) |
| | rnf8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (491 aa) |
| | sumo2 | Small ubiquitin-related modifier. (95 aa) |
| | brca1 | Breast cancer type 1 susceptibility protein isoform X2. (1369 aa) |
| | ENSIPUP00000033019 | annotation not available (92 aa) |
| | herc2 | E3 ubiquitin-protein ligase HERC2. (4717 aa) |
| | rad17 | Cell cycle checkpoint protein RAD17 isoform X4. (701 aa) |
| | sumo2-2 | Small ubiquitin-related modifier. (95 aa) |
| | tp53bp1 | Tumor suppressor p53-binding protein 1 isoform X3. (1750 aa) |
| | pold1 | DNA polymerase. (1066 aa) |
| | ankrd11 | Ankyrin repeat domain-containing protein 11 isoform X2. (2820 aa) |
| | rad51d | DNA repair protein RAD51 homolog 4. (331 aa) |
| | pwwp2a | PWWP domain-containing protein 2A. (668 aa) |
| | pcna | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (297 aa) |
| | rfc2 | Replication factor C subunit 2. (357 aa) |
| | rad9b | Cell cycle checkpoint control protein RAD9B isoform X1. (412 aa) |
| | spidr | DNA repair-scaffolding protein isoform X2. (862 aa) |
| | ube2v2 | Ubiquitin-conjugating enzyme E2 variant 2. (148 aa) |
| | LOC108260489 | Histone H2B; Belongs to the histone H2B family. (117 aa) |
| | ube2i | SUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family. (177 aa) |
| | blm | Bloom syndrome protein isoform X1. (1132 aa) |
| | exd2 | Exonuclease 3'-5' domain-containing protein 2 isoform X1. (631 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (698 aa) |
| | LOC108262486 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (96 aa) |
| | LOC108262497 | Histone H4-like. (96 aa) |
| | ppp4r2 | Serine/threonine-protein phosphatase 4 regulatory subunit 2. (408 aa) |
| | pias4 | E3 SUMO-protein ligase PIAS4. (506 aa) |
| | palb2 | Partner and localizer of BRCA2 isoform X2. (1316 aa) |
| | LOC108262536 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (100 aa) |
| | rbbp8 | DNA endonuclease RBBP8. (74 aa) |
| | LOC108261379 | Histone H2B 1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (124 aa) |
| | LOC108262589 | Histone H4-like. (96 aa) |
| | LOC108255684 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC108262596 | Histone H4-like. (96 aa) |
| | ENSIPUP00000002007 | annotation not available (133 aa) |
| | LOC108262617 | Histone H2B-like. (103 aa) |
| | LOC108262621 | Histone H4-like. (75 aa) |
| | ENSIPUP00000002141 | annotation not available (67 aa) |
| | LOC108262673 | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | chek1 | Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (466 aa) |
| | wrn | Werner syndrome ATP-dependent helicase isoform X1. (1429 aa) |
| | ENSIPUP00000002932 | annotation not available (108 aa) |
| | meiob | Meiosis-specific with OB domain-containing protein. (466 aa) |
| | pold3 | DNA polymerase delta subunit 3 isoform X1. (471 aa) |
| | pold2 | DNA polymerase delta subunit 2. (467 aa) |
| | xrcc2 | DNA repair protein XRCC2. (307 aa) |
| | ENSIPUP00000003801 | annotation not available (96 aa) |
