40 items (Ictalurus punctatus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fancc	Fanconi anemia group C protein. (545 aa)
	fance	Fanconi anemia group E protein. (509 aa)
	dclre1b	5' exonuclease Apollo. (588 aa)
	ercc4	DNA repair endonuclease XPF. (899 aa)
	meiob	Meiosis-specific with OB domain-containing protein. (466 aa)
	mus81	Crossover junction endonuclease MUS81. (627 aa)
	nutf2	Nuclear transport factor 2. (127 aa)
	proser1	Proline and serine-rich protein 1 isoform X2. (770 aa)
	eme1	Crossover junction endonuclease EME1. (516 aa)
	fanci	Fanconi anemia group I protein. (1224 aa)
	cenpx	Centromere protein X. (81 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (606 aa)
	LOC108271937	Crossover junction endonuclease EME1-like. (431 aa)
	fan1	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (991 aa)
	uba52	ubiquitin-60S ribosomal protein L40 isoform X1. (128 aa)
	kxd1	kxDL motif-containing protein 1 isoform X2. (187 aa)
	usp1	Ubiquitin carboxyl-terminal hydrolase. (765 aa)
	poln	DNA polymerase nu. (1192 aa)
	fancg	Fanconi anemia group G protein isoform X1. (621 aa)
	LOC108268031	WD repeat-containing protein 48 isoform X1. (677 aa)
	ube2t	Ubiquitin-conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (203 aa)
	atrip	ATR-interacting protein. (754 aa)
	slx4	Structure-specific endonuclease subunit SLX4. (1195 aa)
	LOC108272412	Replication protein A 32 kDa subunit-like. (251 aa)
	ercc1	DNA excision repair protein ERCC-1. (367 aa)
	faap100	Fanconi anemia core complex-associated protein 100. (844 aa)
	fancm	Fanconi anemia group M protein. (1982 aa)
	rpa2	Replication protein A 32 kDa subunit. (294 aa)
	rps27a	Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...] (156 aa)
	fancb	Fanconi anemia group B protein. (873 aa)
	atr	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2616 aa)
	faap24	Fanconi anemia core complex-associated protein 24 isoform X2. (228 aa)
	dclre1a	DNA cross-link repair 1A protein isoform X1. (967 aa)
	rpa3	Replication protein A 14 kDa subunit. (122 aa)
	fancd2	Fanconi anemia group D2 protein isoform X2. (1438 aa)
	LOC108267068	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (263 aa)
	fancf	Fanconi anemia group F protein. (363 aa)
	fancl	E3 ubiquitin-protein ligase FANCL isoform X1. (371 aa)
	LOC108271797	Centromere protein S-like. (141 aa)
	wdr48	WD repeat-containing protein 48 isoform X1. (681 aa)

Your Current Organism:

Ictalurus punctatus

NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC108267068	LOC108268031	ENSIPUP00000028320	ENSIPUP00000012669	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	WD repeat-containing protein 48 isoform X1.	0.457
LOC108267068	LOC108271937	ENSIPUP00000028320	ENSIPUP00000006642	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	Crossover junction endonuclease EME1-like.	0.483
LOC108267068	atr	ENSIPUP00000028320	ENSIPUP00000022878	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	0.571
LOC108267068	cenpx	ENSIPUP00000028320	ENSIPUP00000006205	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	Centromere protein X.	0.515
LOC108267068	dclre1a	ENSIPUP00000028320	ENSIPUP00000025251	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	DNA cross-link repair 1A protein isoform X1.	0.671
LOC108267068	dclre1b	ENSIPUP00000028320	ENSIPUP00000001189	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	5' exonuclease Apollo.	0.671
LOC108267068	eme1	ENSIPUP00000028320	ENSIPUP00000005457	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	Crossover junction endonuclease EME1.	0.847
LOC108267068	ercc1	ENSIPUP00000028320	ENSIPUP00000018464	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	DNA excision repair protein ERCC-1.	0.874
LOC108267068	ercc4	ENSIPUP00000028320	ENSIPUP00000002451	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	DNA repair endonuclease XPF.	0.901
LOC108267068	faap100	ENSIPUP00000028320	ENSIPUP00000018735	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	Fanconi anemia core complex-associated protein 100.	0.501
LOC108267068	faap24	ENSIPUP00000028320	ENSIPUP00000024165	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	Fanconi anemia core complex-associated protein 24 isoform X2.	0.807
LOC108267068	fan1	ENSIPUP00000028320	ENSIPUP00000006934	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.	0.810
LOC108267068	fancb	ENSIPUP00000028320	ENSIPUP00000022639	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	Fanconi anemia group B protein.	0.545
LOC108267068	fancc	ENSIPUP00000028320	ENSIPUP00000000403	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	Fanconi anemia group C protein.	0.538
LOC108267068	fancd2	ENSIPUP00000028320	ENSIPUP00000028040	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	Fanconi anemia group D2 protein isoform X2.	0.810
LOC108267068	fance	ENSIPUP00000028320	ENSIPUP00000001001	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	Fanconi anemia group E protein.	0.494
LOC108267068	fancf	ENSIPUP00000028320	ENSIPUP00000033260	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	Fanconi anemia group F protein.	0.543
LOC108267068	fancg	ENSIPUP00000028320	ENSIPUP00000011600	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	Fanconi anemia group G protein isoform X1.	0.528
LOC108267068	fanci	ENSIPUP00000028320	ENSIPUP00000006014	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	Fanconi anemia group I protein.	0.788
LOC108267068	fancl	ENSIPUP00000028320	ENSIPUP00000034697	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	E3 ubiquitin-protein ligase FANCL isoform X1.	0.652