STRINGSTRING
stk11 stk11 LOC108278840 LOC108278840 ENSIPUP00000011577 ENSIPUP00000011577 LOC108260283 LOC108260283 atm atm LOC108278443 LOC108278443 ankrd12 ankrd12 atr atr chek2 chek2 dyrk2 dyrk2 tp53inp2 tp53inp2 taf12 taf12 rad9a rad9a LOC108269282 LOC108269282 taf1 taf1 LOC108272361 LOC108272361 ccna2 ccna2 PRKAB2 PRKAB2 csnk2b csnk2b mapkapk5 mapkapk5 top3a top3a rpa3 rpa3 taf7l taf7l nuak2 nuak2 mre11 mre11 taf5l taf5l mdm4 mdm4 taf2 taf2 LOC108265726 LOC108265726 exd2 exd2 LOC108275632 LOC108275632 blm blm rhno1 rhno1 dna2 dna2 aurkb aurkb cdk5 cdk5 slf1 slf1 taf13 taf13 plk3 plk3 exo1 exo1 LOC108255359 LOC108255359 rad9b rad9b rfc2 rfc2 mdm2 mdm2 hus1 hus1 cdk5r1 cdk5r1 rmi2 rmi2 LOC108267915 LOC108267915 rfc5 rfc5 cdca7 cdca7 tbp tbp tp53inp1 tp53inp1 noc2l noc2l tp53 tp53 taf6 taf6 brca1 brca1 csnk2a2 csnk2a2 taf3 taf3 rmi1 rmi1 supt16h supt16h LOC108264743 LOC108264743 ccna1 ccna1 hipk3 hipk3 rfc3 rfc3 LOC108266099 LOC108266099 tbpl1 tbpl1 atrip atrip tpx2 tpx2 LOC108270938 LOC108270938 pin1 pin1 LOC108272412 LOC108272412 LOC108266105 LOC108266105 dyrk4 dyrk4 rfc4 rfc4 LOC108267467 LOC108267467 tdrd3 tdrd3 cdk2 cdk2 rad50 rad50 LOC108257452 LOC108257452 LOC108274635 LOC108274635 LOC108265824 LOC108265824 LOC108272557 LOC108272557 prkaa2 prkaa2 taf11 taf11 LOC108262778 LOC108262778 kat5 kat5 hipk2 hipk2 rpa2 rpa2 LOC108258144 LOC108258144 taf5 taf5 prkab1 prkab1 LOC108276173 LOC108276173 rad17 rad17 prkag1 prkag1 ankrd11 ankrd11 taf4 taf4 LOC108254861 LOC108254861 LOC108254806 LOC108254806 dyrk3 dyrk3 pwwp2a pwwp2a rps27a rps27a rbbp8 rbbp8 ENSIPUP00000002028 ENSIPUP00000002028 chek1 chek1 tbpl2 tbpl2 aakb1 aakb1 wrn wrn meiob meiob LOC108255211 LOC108255211 tp53rk tp53rk taf10 taf10 nbn nbn cdca7l cdca7l rpa1 rpa1 recql4 recql4 topbp1 topbp1 LOC108256599 LOC108256599 uba52 uba52 LOC108267736 LOC108267736 kxd1 kxd1 LOC108279456 LOC108279456 LOC108264637 LOC108264637 LOC108269134 LOC108269134 LOC108258362 LOC108258362 nuak1 nuak1 rad1 rad1 LOC108276094 LOC108276094
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
stk11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (439 aa)
LOC108278840Transcription initiation factor TFIID subunit 9-like isoform X1. (249 aa)
ENSIPUP00000011577DNA replication ATP-dependent helicase/nuclease DNA2-like. (96 aa)
LOC108260283Non-specific serine/threonine protein kinase. (611 aa)
atmNon-specific serine/threonine protein kinase. (3076 aa)
LOC108278443Aurora kinase B-like; Belongs to the protein kinase superfamily. (398 aa)
ankrd12Ankyrin repeat domain-containing protein 12 isoform X2. (2035 aa)
atrSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2616 aa)
chek2Serine/threonine-protein kinase Chk2. (539 aa)
dyrk2Dual specificity tyrosine-phosphorylation-regulated kinase 2. (580 aa)
tp53inp2Tumor protein p53-inducible nuclear protein 2 isoform X1. (279 aa)
taf12Transcription initiation factor TFIID subunit 12 isoform X1. (167 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (384 aa)
LOC108269282FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (700 aa)
taf1Transcription initiation factor TFIID subunit. (1702 aa)
LOC108272361Cyclin-dependent kinase 5 activator. (320 aa)
ccna2cyclin-A2; Belongs to the cyclin family. (423 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2-like. (272 aa)
csnk2bCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa)
mapkapk5MAP kinase-activated protein kinase 5. (474 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (999 aa)
rpa3Replication protein A 14 kDa subunit. (122 aa)
taf7lTranscription initiation factor TFIID subunit 7-like isoform X1. (362 aa)
nuak2NUAK family SNF1-like kinase 2. (607 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (698 aa)
taf5lTATA-box binding protein associated factor 5 like. (604 aa)
mdm4Protein Mdm4 isoform X2; Belongs to the MDM2/MDM4 family. (468 aa)
taf2Transcription initiation factor TFIID subunit 2. (1138 aa)
LOC108265726Mitogen-activated protein kinase. (361 aa)
exd2Exonuclease 3'-5' domain-containing protein 2 isoform X1. (631 aa)
LOC108275632Cyclin-dependent kinase 5 activator 1-like. (293 aa)
blmBloom syndrome protein isoform X1. (1132 aa)
rhno1RAD9, HUS1, RAD1-interacting nuclear orphan protein 1. (293 aa)
dna2DNA replication ATP-dependent helicase/nuclease DNA2 isoform X4. (1343 aa)
aurkbSerine/threonine-protein kinase 12; Belongs to the protein kinase superfamily. (322 aa)
cdk5Cell division protein kinase 5; Belongs to the protein kinase superfamily. (292 aa)
slf1SMC5-SMC6 complex localization factor protein 1 isoform X1. (891 aa)
taf13Transcription initiation factor TFIID subunit 13. (124 aa)
plk3Serine/threonine-protein kinase PLK. (662 aa)
exo1Exonuclease 1 isoform X1. (769 aa)
LOC108255359Uncharacterized protein LOC108255359 isoform X2. (1394 aa)
rad9bCell cycle checkpoint control protein RAD9B isoform X1. (412 aa)
rfc2Replication factor C subunit 2. (357 aa)
mdm2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (473 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (281 aa)
cdk5r1Cyclin-dependent kinase 5 activator. (321 aa)
rmi2RecQ-mediated Genome instability protein 2. (146 aa)
LOC108267915Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (394 aa)
rfc5Replication factor C subunit 5. (339 aa)
cdca7Cell division cycle-associated protein 7. (400 aa)
tbpTATA-box-binding protein. (303 aa)
tp53inp1Tumor protein p53-inducible nuclear protein 1. (242 aa)
noc2lNucleolar complex protein 2 homolog. (745 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family. (376 aa)
taf6Transcription initiation factor TFIID subunit 6. (584 aa)
brca1Breast cancer type 1 susceptibility protein isoform X2. (1369 aa)
csnk2a2Casein kinase II subunit alpha' isoform X1; Belongs to the protein kinase superfamily. (350 aa)
taf3Transcription initiation factor TFIID subunit 3. (876 aa)
rmi1recQ-mediated genome instability protein 1. (649 aa)
supt16hFACT complex subunit SPT16. (1033 aa)
LOC108264743Transcription initiation factor TFIID subunit 4-like isoform X1. (1010 aa)
ccna1cyclin-A1 isoform X2; Belongs to the cyclin family. (397 aa)
hipk3Homeodomain-interacting protein kinase 3 isoform X1. (1188 aa)
rfc3Replication factor C subunit 3. (356 aa)
LOC108266099Cyclin-dependent kinase 5 activator 2-like isoform X2. (142 aa)
tbpl1TATA box-binding protein-like protein 1 isoform X1. (186 aa)
atripATR-interacting protein. (754 aa)
tpx2Targeting protein for Xklp2 isoform X1. (742 aa)
LOC108270938Casein kinase II subunit alpha'-like; Belongs to the protein kinase superfamily. (351 aa)
pin1Peptidyl-prolyl cis-trans isomerase. (158 aa)
LOC108272412Replication protein A 32 kDa subunit-like. (251 aa)
LOC1082661055'-AMP-activated protein kinase subunit gamma-1-like isoform X3. (336 aa)
dyrk4Dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X2. (618 aa)
rfc4Replication factor C subunit 4 isoform X1. (358 aa)
LOC1082674675'-AMP-activated protein kinase subunit gamma-1-like isoform X3. (537 aa)
tdrd3Tudor domain-containing protein 3. (801 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (301 aa)
rad50DNA repair protein RAD50 isoform X1. (1311 aa)
LOC108257452Casein kinase II subunit alpha-like isoform X1; Belongs to the protein kinase superfamily. (393 aa)
LOC108274635NUAK family SNF1-like kinase 1. (630 aa)
LOC108265824Uncharacterized protein LOC108265824 isoform X1. (477 aa)
LOC108272557Cyclin-dependent kinase 5 activator. (310 aa)
prkaa2Non-specific serine/threonine protein kinase. (546 aa)
taf11Transcription initiation factor TFIID subunit 11 isoform X2. (207 aa)
LOC108262778FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (698 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (435 aa)
hipk2Homeodomain-interacting protein kinase 2 isoform X1. (1242 aa)
rpa2Replication protein A 32 kDa subunit. (294 aa)
LOC108258144Transcription initiation factor TFIID subunit 4-like isoform X1. (863 aa)
taf5Transcription initiation factor TFIID subunit 5 isoform X1. (738 aa)
prkab15'-AMP-activated protein kinase subunit beta-1. (319 aa)
LOC108276173Homeodomain-interacting protein kinase 1-like isoform X5. (1132 aa)
rad17Cell cycle checkpoint protein RAD17 isoform X4. (701 aa)
prkag15'-AMP-activated protein kinase subunit gamma-1. (349 aa)
ankrd11Ankyrin repeat domain-containing protein 11 isoform X2. (2820 aa)
taf4Transcription initiation factor TFIID subunit 4 isoform X1. (916 aa)
LOC108254861Homeodomain-interacting protein kinase 1-like isoform X1. (1107 aa)
LOC108254806Mitogen-activated protein kinase 14A-like. (363 aa)
dyrk3Dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X1. (582 aa)
pwwp2aPWWP domain-containing protein 2A. (668 aa)
rps27aUbiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...] (156 aa)
rbbp8DNA endonuclease RBBP8. (74 aa)
ENSIPUP00000002028annotation not available (46 aa)
chek1Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (466 aa)
tbpl2TATA box-binding protein-like protein 2. (311 aa)
aakb15'-AMP-activated protein kinase subunit beta-1 isoform X1. (252 aa)
wrnWerner syndrome ATP-dependent helicase isoform X1. (1429 aa)
meiobMeiosis-specific with OB domain-containing protein. (466 aa)
LOC108255211Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (448 aa)
tp53rkTP53-regulating kinase. (237 aa)
taf10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (227 aa)
nbnNibrin. (831 aa)
cdca7lCell division cycle-associated 7-like protein. (473 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (606 aa)
recql4ATP-dependent DNA helicase Q4. (1490 aa)
topbp1DNA topoisomerase 2-binding protein 1 isoform X7. (1561 aa)
LOC1082565995'-AMP-activated protein kinase subunit gamma-1-like isoform X1. (561 aa)
uba52ubiquitin-60S ribosomal protein L40 isoform X1. (128 aa)
LOC108267736Casein kinase II subunit alpha-like. (403 aa)
kxd1kxDL motif-containing protein 1 isoform X2. (187 aa)
LOC108279456Mitogen-activated protein kinase. (361 aa)
LOC108264637Homeodomain-interacting protein kinase 3-like isoform X1. (1311 aa)
LOC108269134Transcription initiation factor TFIID subunit 4-like isoform X1. (1016 aa)
LOC1082583625'-AMP-activated protein kinase subunit gamma-1-like isoform X2. (327 aa)
nuak1NUAK family SNF1-like kinase 1 isoform X1. (608 aa)
rad1Cell cycle checkpoint protein RAD1 isoform X1. (291 aa)
LOC108276094Mitogen-activated protein kinase. (359 aa)
Your Current Organism:
Ictalurus punctatus
NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish
Server load: low (26%) [HD]