STRINGSTRING
chek2 chek2 ube2v2 ube2v2 LOC108260489 LOC108260489 blm blm exd2 exd2 mre11 mre11 LOC108262486 LOC108262486 LOC108262497 LOC108262497 pias4 pias4 LOC108262536 LOC108262536 rbbp8 rbbp8 LOC108261379 LOC108261379 LOC108262589 LOC108262589 LOC108255684 LOC108255684 LOC108262596 LOC108262596 ENSIPUP00000002007 ENSIPUP00000002007 LOC108262617 LOC108262617 LOC108262621 LOC108262621 ENSIPUP00000002141 ENSIPUP00000002141 LOC108262673 LOC108262673 LOC100305105 LOC100305105 chek1 chek1 wrn wrn ENSIPUP00000002932 ENSIPUP00000002932 meiob meiob LOC108265441 LOC108265441 nbn nbn ENSIPUP00000005160 ENSIPUP00000005160 LOC108272432 LOC108272432 LOC108272324 LOC108272324 abraxas1 abraxas1 LOC108261983 LOC108261983 cdca7l cdca7l rpa1 rpa1 recql4 recql4 topbp1 topbp1 mdc1 mdc1 ywhae ywhae ENSIPUP00000009144 ENSIPUP00000009144 LOC108277171 LOC108277171 cdc25b cdc25b rad1 rad1 uimc1 uimc1 nsd2 nsd2 babam1 babam1 ENSIPUP00000011444 ENSIPUP00000011444 ENSIPUP00000011577 ENSIPUP00000011577 ENSIPUP00000011897 ENSIPUP00000011897 LOC108261425 LOC108261425 atm atm LOC108261488 LOC108261488 ENSIPUP00000012797 ENSIPUP00000012797 rmi1 rmi1 LOC108261379-2 LOC108261379-2 ENSIPUP00000013437 ENSIPUP00000013437 LOC108261690 LOC108261690 ENSIPUP00000013757 ENSIPUP00000013757 babam2 babam2 rfc3 rfc3 brcc3 brcc3 LOC108257302 LOC108257302 LOC108261712 LOC108261712 LOC108271195 LOC108271195 ENSIPUP00000016196 ENSIPUP00000016196 ENSIPUP00000016437 ENSIPUP00000016437 atrip atrip LOC108258592 LOC108258592 LOC108272412 LOC108272412 ENSIPUP00000017001 ENSIPUP00000017001 LOC108261860 LOC108261860 LOC108261861 LOC108261861 ENSIPUP00000017440 ENSIPUP00000017440 LOC108261901 LOC108261901 LOC108261899 LOC108261899 ENSIPUP00000017662 ENSIPUP00000017662 rfc4 rfc4 LOC108255684-2 LOC108255684-2 LOC108261964 LOC108261964 LOC108261379-3 LOC108261379-3 tdrd3 tdrd3 143g1 143g1 ENSIPUP00000018324 ENSIPUP00000018324 rad50 rad50 LOC108255684-3 LOC108255684-3 LOC108262131 LOC108262131 143b1 143b1 ENSIPUP00000018991 ENSIPUP00000018991 ENSIPUP00000019080 ENSIPUP00000019080 LOC108270562 LOC108270562 LOC108255684-4 LOC108255684-4 LOC108255684-5 LOC108255684-5 LOC108262397 LOC108262397 LOC108262407 LOC108262407 LOC108260056 LOC108260056 kat5 kat5 rpa2 rpa2 atr atr cdk1 cdk1 rad9a rad9a ccnb1 ccnb1 top3a top3a ube2n ube2n rpa3 rpa3 LOC108277419 LOC108277419 ankrd12 ankrd12 rhno1 rhno1 dna2 dna2 slf1 slf1 exo1 exo1 LOC108255359 LOC108255359 hus1 hus1 LOC108264466 LOC108264466 rmi2 rmi2 LOC108267915 LOC108267915 rfc5 rfc5 cdca7 cdca7 LOC108261097 LOC108261097 rnf169 rnf169 LOC108269934 LOC108269934 rnf168 rnf168 tp53 tp53 rnf8 rnf8 brca1 brca1 ENSIPUP00000033019 ENSIPUP00000033019 herc2 herc2 ywhah ywhah rad17 rad17 tp53bp1 tp53bp1 wee2 wee2 ywhaq ywhaq ankrd11 ankrd11 rfc2 rfc2 rad9b rad9b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
chek2Serine/threonine-protein kinase Chk2. (539 aa)
ube2v2Ubiquitin-conjugating enzyme E2 variant 2. (148 aa)
LOC108260489Histone H2B; Belongs to the histone H2B family. (117 aa)
blmBloom syndrome protein isoform X1. (1132 aa)
exd2Exonuclease 3'-5' domain-containing protein 2 isoform X1. (631 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (698 aa)
LOC108262486Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (96 aa)
LOC108262497Histone H4-like. (96 aa)
pias4E3 SUMO-protein ligase PIAS4. (506 aa)
LOC108262536Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (100 aa)
rbbp8DNA endonuclease RBBP8. (74 aa)
LOC108261379Histone H2B 1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (124 aa)
LOC108262589Histone H4-like. (96 aa)
LOC108255684Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC108262596Histone H4-like. (96 aa)
ENSIPUP00000002007annotation not available (133 aa)
LOC108262617Histone H2B-like. (103 aa)
LOC108262621Histone H4-like. (75 aa)
ENSIPUP00000002141annotation not available (67 aa)
LOC108262673Histone H2B; Belongs to the histone H2B family. (124 aa)
LOC10030510514-3-3 protein beta/alpha-A; Belongs to the 14-3-3 family. (232 aa)
chek1Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (466 aa)
wrnWerner syndrome ATP-dependent helicase isoform X1. (1429 aa)
ENSIPUP00000002932annotation not available (108 aa)
meiobMeiosis-specific with OB domain-containing protein. (466 aa)
LOC10826544114-3-3 protein beta/alpha-A-like; Belongs to the 14-3-3 family. (245 aa)
nbnNibrin. (831 aa)
ENSIPUP00000005160annotation not available (81 aa)
LOC108272432Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (102 aa)
LOC108272324Histone H2B; Belongs to the histone H2B family. (124 aa)
abraxas1BRCA1-A complex subunit Abraxas. (393 aa)
LOC108261983Histone H2B-like; Belongs to the histone H2B family. (88 aa)
cdca7lCell division cycle-associated 7-like protein. (473 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (606 aa)
recql4ATP-dependent DNA helicase Q4. (1490 aa)
topbp1DNA topoisomerase 2-binding protein 1 isoform X7. (1561 aa)
mdc1Mediator of DNA damage checkpoint protein 1 isoform X2. (1909 aa)
ywhae14-3-3 protein epsilon isoform X1; Belongs to the 14-3-3 family. (255 aa)
ENSIPUP00000009144Histone H2B 3. (118 aa)
LOC108277171Histone H2A; Belongs to the histone H2A family. (128 aa)
cdc25bM-phase inducer phosphatase 2. (570 aa)
rad1Cell cycle checkpoint protein RAD1 isoform X1. (291 aa)
uimc1BRCA1-A complex subunit RAP80 isoform X1. (960 aa)
nsd2Histone-lysine N-methyltransferase NSD2 isoform X2. (1480 aa)
babam1BRISC and BRCA1-A complex member 1. (369 aa)
ENSIPUP00000011444annotation not available (131 aa)
ENSIPUP00000011577DNA replication ATP-dependent helicase/nuclease DNA2-like. (96 aa)
ENSIPUP00000011897annotation not available (218 aa)
LOC108261425Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (104 aa)
atmNon-specific serine/threonine protein kinase. (3076 aa)
LOC108261488Histone H2B; Belongs to the histone H2B family. (124 aa)
ENSIPUP00000012797annotation not available (109 aa)
rmi1recQ-mediated genome instability protein 1. (649 aa)
LOC108261379-2Histone H2B-like. (124 aa)
ENSIPUP00000013437annotation not available (145 aa)
LOC108261690Histone H4. (96 aa)
ENSIPUP00000013757annotation not available (100 aa)
babam2BRCA1-A complex subunit BRE. (386 aa)
rfc3Replication factor C subunit 3. (356 aa)
brcc3Lys-63-specific deubiquitinase BRCC36 isoform X1. (260 aa)
LOC10825730214-3-3 protein zeta/delta-like; Belongs to the 14-3-3 family. (243 aa)
LOC108261712Histone H4-like. (81 aa)
LOC108271195Wee1-like protein kinase. (285 aa)
ENSIPUP00000016196annotation not available (490 aa)
ENSIPUP00000016437annotation not available (175 aa)
atripATR-interacting protein. (754 aa)
LOC108258592Histone H2A; Belongs to the histone H2A family. (132 aa)
LOC108272412Replication protein A 32 kDa subunit-like. (251 aa)
ENSIPUP00000017001annotation not available (67 aa)
LOC108261860Histone H4-like. (96 aa)
LOC108261861Histone H2B; Belongs to the histone H2B family. (125 aa)
ENSIPUP00000017440annotation not available (144 aa)
LOC108261901Histone H4-like. (96 aa)
LOC108261899Histone H2B-like. (117 aa)
ENSIPUP00000017662annotation not available (150 aa)
rfc4Replication factor C subunit 4 isoform X1. (358 aa)
LOC108255684-2Histone H4. (103 aa)
LOC108261964Histone H2B; Belongs to the histone H2B family. (124 aa)
LOC108261379-3Histone H2B-like. (124 aa)
tdrd3Tudor domain-containing protein 3. (801 aa)
143g114-3-3 protein gamma-1; Belongs to the 14-3-3 family. (247 aa)
ENSIPUP00000018324annotation not available (150 aa)
rad50DNA repair protein RAD50 isoform X1. (1311 aa)
LOC108255684-3Histone H4. (103 aa)
LOC108262131Histone H2B-like. (90 aa)
143b114-3-3 protein beta/alpha-1; Belongs to the 14-3-3 family. (244 aa)
ENSIPUP00000018991annotation not available (96 aa)
ENSIPUP00000019080annotation not available (285 aa)
LOC108270562Wee1-like protein kinase. (532 aa)
LOC108255684-4Histone H4. (103 aa)
LOC108255684-5Histone H4. (103 aa)
LOC108262397Histone H4-like. (96 aa)
LOC108262407Histone H2B; Belongs to the histone H2B family. (164 aa)
LOC10826005614-3-3 protein epsilon-like isoform X1; Belongs to the 14-3-3 family. (254 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (435 aa)
rpa2Replication protein A 32 kDa subunit. (294 aa)
atrSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2616 aa)
cdk1Cyclin-dependent kinase 1 isoform X1; Belongs to the protein kinase superfamily. (302 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (384 aa)
ccnb1G2/mitotic-specific cyclin-B1 isoform X2; Belongs to the cyclin family. (401 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (999 aa)
ube2nUbiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
rpa3Replication protein A 14 kDa subunit. (122 aa)
LOC10827741914-3-3 protein gamma-2-like; Belongs to the 14-3-3 family. (247 aa)
ankrd12Ankyrin repeat domain-containing protein 12 isoform X2. (2035 aa)
rhno1RAD9, HUS1, RAD1-interacting nuclear orphan protein 1. (293 aa)
dna2DNA replication ATP-dependent helicase/nuclease DNA2 isoform X4. (1343 aa)
slf1SMC5-SMC6 complex localization factor protein 1 isoform X1. (891 aa)
exo1Exonuclease 1 isoform X1. (769 aa)
LOC108255359Uncharacterized protein LOC108255359 isoform X2. (1394 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (281 aa)
LOC108264466Wee1-like protein kinase. (615 aa)
rmi2RecQ-mediated Genome instability protein 2. (146 aa)
LOC108267915Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (394 aa)
rfc5Replication factor C subunit 5. (339 aa)
cdca7Cell division cycle-associated protein 7. (400 aa)
LOC108261097Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
rnf169E3 ubiquitin-protein ligase RNF169. (619 aa)
LOC10826993414-3-3 protein beta/alpha-like; Belongs to the 14-3-3 family. (240 aa)
rnf168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (461 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family. (376 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (491 aa)
brca1Breast cancer type 1 susceptibility protein isoform X2. (1369 aa)
ENSIPUP00000033019annotation not available (92 aa)
herc2E3 ubiquitin-protein ligase HERC2. (4717 aa)
ywhah14-3-3 protein gamma; Belongs to the 14-3-3 family. (247 aa)
rad17Cell cycle checkpoint protein RAD17 isoform X4. (701 aa)
tp53bp1Tumor suppressor p53-binding protein 1 isoform X3. (1750 aa)
wee2Wee1-like protein kinase. (546 aa)
ywhaq14-3-3 protein theta; Belongs to the 14-3-3 family. (244 aa)
ankrd11Ankyrin repeat domain-containing protein 11 isoform X2. (2820 aa)
rfc2Replication factor C subunit 2. (357 aa)
rad9bCell cycle checkpoint control protein RAD9B isoform X1. (412 aa)
Your Current Organism:
Ictalurus punctatus
NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish
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