Your Input: | |
| | chek2 | Serine/threonine-protein kinase Chk2. (539 aa) |
| | ube2v2 | Ubiquitin-conjugating enzyme E2 variant 2. (148 aa) |
| | LOC108260489 | Histone H2B; Belongs to the histone H2B family. (117 aa) |
| | blm | Bloom syndrome protein isoform X1. (1132 aa) |
| | exd2 | Exonuclease 3'-5' domain-containing protein 2 isoform X1. (631 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (698 aa) |
| | LOC108262486 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (96 aa) |
| | LOC108262497 | Histone H4-like. (96 aa) |
| | pias4 | E3 SUMO-protein ligase PIAS4. (506 aa) |
| | LOC108262536 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (100 aa) |
| | rbbp8 | DNA endonuclease RBBP8. (74 aa) |
| | LOC108261379 | Histone H2B 1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (124 aa) |
| | LOC108262589 | Histone H4-like. (96 aa) |
| | LOC108255684 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC108262596 | Histone H4-like. (96 aa) |
| | ENSIPUP00000002007 | annotation not available (133 aa) |
| | LOC108262617 | Histone H2B-like. (103 aa) |
| | LOC108262621 | Histone H4-like. (75 aa) |
| | ENSIPUP00000002141 | annotation not available (67 aa) |
| | LOC108262673 | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | LOC100305105 | 14-3-3 protein beta/alpha-A; Belongs to the 14-3-3 family. (232 aa) |
| | chek1 | Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (466 aa) |
| | wrn | Werner syndrome ATP-dependent helicase isoform X1. (1429 aa) |
| | ENSIPUP00000002932 | annotation not available (108 aa) |
| | meiob | Meiosis-specific with OB domain-containing protein. (466 aa) |
| | LOC108265441 | 14-3-3 protein beta/alpha-A-like; Belongs to the 14-3-3 family. (245 aa) |
| | nbn | Nibrin. (831 aa) |
| | ENSIPUP00000005160 | annotation not available (81 aa) |
| | LOC108272432 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (102 aa) |
| | LOC108272324 | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | abraxas1 | BRCA1-A complex subunit Abraxas. (393 aa) |
| | LOC108261983 | Histone H2B-like; Belongs to the histone H2B family. (88 aa) |
| | cdca7l | Cell division cycle-associated 7-like protein. (473 aa) |
| | rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (606 aa) |
| | recql4 | ATP-dependent DNA helicase Q4. (1490 aa) |
| | topbp1 | DNA topoisomerase 2-binding protein 1 isoform X7. (1561 aa) |
| | mdc1 | Mediator of DNA damage checkpoint protein 1 isoform X2. (1909 aa) |
| | ywhae | 14-3-3 protein epsilon isoform X1; Belongs to the 14-3-3 family. (255 aa) |
| | ENSIPUP00000009144 | Histone H2B 3. (118 aa) |
| | LOC108277171 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | cdc25b | M-phase inducer phosphatase 2. (570 aa) |
| | rad1 | Cell cycle checkpoint protein RAD1 isoform X1. (291 aa) |
| | uimc1 | BRCA1-A complex subunit RAP80 isoform X1. (960 aa) |
| | nsd2 | Histone-lysine N-methyltransferase NSD2 isoform X2. (1480 aa) |
| | babam1 | BRISC and BRCA1-A complex member 1. (369 aa) |
| | ENSIPUP00000011444 | annotation not available (131 aa) |
| | ENSIPUP00000011577 | DNA replication ATP-dependent helicase/nuclease DNA2-like. (96 aa) |
| | ENSIPUP00000011897 | annotation not available (218 aa) |
| | LOC108261425 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (104 aa) |
| | atm | Non-specific serine/threonine protein kinase. (3076 aa) |
| | LOC108261488 | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | ENSIPUP00000012797 | annotation not available (109 aa) |
| | rmi1 | recQ-mediated genome instability protein 1. (649 aa) |
| | LOC108261379-2 | Histone H2B-like. (124 aa) |
| | ENSIPUP00000013437 | annotation not available (145 aa) |
| | LOC108261690 | Histone H4. (96 aa) |
| | ENSIPUP00000013757 | annotation not available (100 aa) |
| | babam2 | BRCA1-A complex subunit BRE. (386 aa) |
| | rfc3 | Replication factor C subunit 3. (356 aa) |
| | brcc3 | Lys-63-specific deubiquitinase BRCC36 isoform X1. (260 aa) |
| | LOC108257302 | 14-3-3 protein zeta/delta-like; Belongs to the 14-3-3 family. (243 aa) |
| | LOC108261712 | Histone H4-like. (81 aa) |
| | LOC108271195 | Wee1-like protein kinase. (285 aa) |
| | ENSIPUP00000016196 | annotation not available (490 aa) |
| | ENSIPUP00000016437 | annotation not available (175 aa) |
| | atrip | ATR-interacting protein. (754 aa) |
| | LOC108258592 | Histone H2A; Belongs to the histone H2A family. (132 aa) |
| | LOC108272412 | Replication protein A 32 kDa subunit-like. (251 aa) |
| | ENSIPUP00000017001 | annotation not available (67 aa) |
| | LOC108261860 | Histone H4-like. (96 aa) |
| | LOC108261861 | Histone H2B; Belongs to the histone H2B family. (125 aa) |
| | ENSIPUP00000017440 | annotation not available (144 aa) |
| | LOC108261901 | Histone H4-like. (96 aa) |
| | LOC108261899 | Histone H2B-like. (117 aa) |
| | ENSIPUP00000017662 | annotation not available (150 aa) |
| | rfc4 | Replication factor C subunit 4 isoform X1. (358 aa) |
| | LOC108255684-2 | Histone H4. (103 aa) |
| | LOC108261964 | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | LOC108261379-3 | Histone H2B-like. (124 aa) |
| | tdrd3 | Tudor domain-containing protein 3. (801 aa) |
| | 143g1 | 14-3-3 protein gamma-1; Belongs to the 14-3-3 family. (247 aa) |
| | ENSIPUP00000018324 | annotation not available (150 aa) |
| | rad50 | DNA repair protein RAD50 isoform X1. (1311 aa) |
| | LOC108255684-3 | Histone H4. (103 aa) |
| | LOC108262131 | Histone H2B-like. (90 aa) |
| | 143b1 | 14-3-3 protein beta/alpha-1; Belongs to the 14-3-3 family. (244 aa) |
| | ENSIPUP00000018991 | annotation not available (96 aa) |
| | ENSIPUP00000019080 | annotation not available (285 aa) |
| | LOC108270562 | Wee1-like protein kinase. (532 aa) |
| | LOC108255684-4 | Histone H4. (103 aa) |
| | LOC108255684-5 | Histone H4. (103 aa) |
| | LOC108262397 | Histone H4-like. (96 aa) |
| | LOC108262407 | Histone H2B; Belongs to the histone H2B family. (164 aa) |
| | LOC108260056 | 14-3-3 protein epsilon-like isoform X1; Belongs to the 14-3-3 family. (254 aa) |
| | kat5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (435 aa) |
| | rpa2 | Replication protein A 32 kDa subunit. (294 aa) |
| | atr | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2616 aa) |
| | cdk1 | Cyclin-dependent kinase 1 isoform X1; Belongs to the protein kinase superfamily. (302 aa) |
| | rad9a | Cell cycle checkpoint control protein; Belongs to the rad9 family. (384 aa) |
| | ccnb1 | G2/mitotic-specific cyclin-B1 isoform X2; Belongs to the cyclin family. (401 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (999 aa) |
| | ube2n | Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | rpa3 | Replication protein A 14 kDa subunit. (122 aa) |
| | LOC108277419 | 14-3-3 protein gamma-2-like; Belongs to the 14-3-3 family. (247 aa) |
| | ankrd12 | Ankyrin repeat domain-containing protein 12 isoform X2. (2035 aa) |
| | rhno1 | RAD9, HUS1, RAD1-interacting nuclear orphan protein 1. (293 aa) |
| | dna2 | DNA replication ATP-dependent helicase/nuclease DNA2 isoform X4. (1343 aa) |
| | slf1 | SMC5-SMC6 complex localization factor protein 1 isoform X1. (891 aa) |
| | exo1 | Exonuclease 1 isoform X1. (769 aa) |
| | LOC108255359 | Uncharacterized protein LOC108255359 isoform X2. (1394 aa) |
| | hus1 | Checkpoint protein; Belongs to the HUS1 family. (281 aa) |
| | LOC108264466 | Wee1-like protein kinase. (615 aa) |
| | rmi2 | RecQ-mediated Genome instability protein 2. (146 aa) |
| | LOC108267915 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (394 aa) |
| | rfc5 | Replication factor C subunit 5. (339 aa) |
| | cdca7 | Cell division cycle-associated protein 7. (400 aa) |
| | LOC108261097 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | rnf169 | E3 ubiquitin-protein ligase RNF169. (619 aa) |
| | LOC108269934 | 14-3-3 protein beta/alpha-like; Belongs to the 14-3-3 family. (240 aa) |
| | rnf168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (461 aa) |
| | tp53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family. (376 aa) |
| | rnf8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (491 aa) |
| | brca1 | Breast cancer type 1 susceptibility protein isoform X2. (1369 aa) |
| | ENSIPUP00000033019 | annotation not available (92 aa) |
| | herc2 | E3 ubiquitin-protein ligase HERC2. (4717 aa) |
| | ywhah | 14-3-3 protein gamma; Belongs to the 14-3-3 family. (247 aa) |
| | rad17 | Cell cycle checkpoint protein RAD17 isoform X4. (701 aa) |
| | tp53bp1 | Tumor suppressor p53-binding protein 1 isoform X3. (1750 aa) |
| | wee2 | Wee1-like protein kinase. (546 aa) |
| | ywhaq | 14-3-3 protein theta; Belongs to the 14-3-3 family. (244 aa) |
| | ankrd11 | Ankyrin repeat domain-containing protein 11 isoform X2. (2820 aa) |
| | rfc2 | Replication factor C subunit 2. (357 aa) |
| | rad9b | Cell cycle checkpoint control protein RAD9B isoform X1. (412 aa) |
