34 items (Ictalurus punctatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC108264340	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (476 aa)
	matk	Tyrosine-protein kinase. (492 aa)
	hbegf	Proheparin-binding EGF-like growth factor. (229 aa)
	LOC108271615	Receptor tyrosine-protein kinase erbB-3-like. (1309 aa)
	nrg2	Pro-neuregulin-2, membrane-bound isoform isoform X4. (737 aa)
	LOC108278233	Beta-crystallin B1-like; Belongs to the beta/gamma-crystallin family. (209 aa)
	LOC108257811	Heat shock protein HSP 90-alpha 1. (727 aa)
	LOC108257813	Heat shock protein HSP 90-alpha 1. (723 aa)
	LOC108262175	Pro-neuregulin-3, membrane-bound isoform-like isoform X3. (347 aa)
	ENSIPUP00000032353	annotation not available (90 aa)
	nrg4	Pro-neuregulin-4, membrane-bound isoform isoform X1. (99 aa)
	LOC108273851	Receptor protein-tyrosine kinase. (1262 aa)
	erbb3	Receptor tyrosine-protein kinase erbB-3 isoform X2. (1415 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
	LOC108268609	Proheparin-binding EGF-like growth factor. (235 aa)
	LOC108273971	Pro-neuregulin-3, membrane-bound isoform-like isoform X2. (726 aa)
	usp8	Ubiquitin carboxyl-terminal hydrolase 8. (1001 aa)
	cul5	Cullin-5 isoform X1; Belongs to the cullin family. (789 aa)
	rps27a	Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...] (156 aa)
	cdc37	Hsp90 Co-chaperone Cdc37. (375 aa)
	rnf41	E3 ubiquitin-protein ligase NRDP1. (318 aa)
	LOC108265862	Tyrosine-protein phosphatase non-receptor type 18-like isoform X1. (506 aa)
	egfr	Receptor protein-tyrosine kinase. (1199 aa)
	akt3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	erbb4	Receptor protein-tyrosine kinase. (1389 aa)
	LOC108258873	Receptor tyrosine-protein kinase erbB-4-like. (1315 aa)
	LOC108259077	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	LOC108258402	Receptor protein-tyrosine kinase. (730 aa)
	uba52	ubiquitin-60S ribosomal protein L40 isoform X1. (128 aa)
	stub1	E3 ubiquitin-protein ligase CHIP isoform X2. (286 aa)
	LOC108278992	Probetacellulin-like isoform X1. (177 aa)
	egf	Pro-epidermal growth factor. (936 aa)
	LOC108268830	Pro-neuregulin-2, membrane-bound isoform-like isoform X1. (708 aa)
	nrg1	Pro-neuregulin-1, membrane-bound isoform isoform X2. (597 aa)

Your Current Organism:

Ictalurus punctatus

NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSIPUP00000032353	egf	ENSIPUP00000032353	ENSIPUP00000005158	annotation not available	Pro-epidermal growth factor.	0.445
ENSIPUP00000032353	nrg4	ENSIPUP00000032353	ENSIPUP00000031051	annotation not available	Pro-neuregulin-4, membrane-bound isoform isoform X1.	0.619
LOC108257811	LOC108257813	ENSIPUP00000033107	ENSIPUP00000033073	Heat shock protein HSP 90-alpha 1.	Heat shock protein HSP 90-alpha 1.	0.900
LOC108257811	LOC108258402	ENSIPUP00000033107	ENSIPUP00000008139	Heat shock protein HSP 90-alpha 1.	Receptor protein-tyrosine kinase.	0.588
LOC108257811	LOC108258873	ENSIPUP00000033107	ENSIPUP00000010147	Heat shock protein HSP 90-alpha 1.	Receptor tyrosine-protein kinase erbB-4-like.	0.588
LOC108257811	LOC108259077	ENSIPUP00000033107	ENSIPUP00000008376	Heat shock protein HSP 90-alpha 1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.711
LOC108257811	LOC108264340	ENSIPUP00000033107	ENSIPUP00000001435	Heat shock protein HSP 90-alpha 1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.697
LOC108257811	LOC108271615	ENSIPUP00000033107	ENSIPUP00000034859	Heat shock protein HSP 90-alpha 1.	Receptor tyrosine-protein kinase erbB-3-like.	0.588
LOC108257811	LOC108273851	ENSIPUP00000033107	ENSIPUP00000029814	Heat shock protein HSP 90-alpha 1.	Receptor protein-tyrosine kinase.	0.588
LOC108257811	akt1	ENSIPUP00000033107	ENSIPUP00000028851	Heat shock protein HSP 90-alpha 1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.697
LOC108257811	akt3	ENSIPUP00000033107	ENSIPUP00000013210	Heat shock protein HSP 90-alpha 1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.698
LOC108257811	cdc37	ENSIPUP00000033107	ENSIPUP00000019873	Heat shock protein HSP 90-alpha 1.	Hsp90 Co-chaperone Cdc37.	0.893
LOC108257811	cul5	ENSIPUP00000033107	ENSIPUP00000023491	Heat shock protein HSP 90-alpha 1.	Cullin-5 isoform X1; Belongs to the cullin family.	0.615
LOC108257811	egf	ENSIPUP00000033107	ENSIPUP00000005158	Heat shock protein HSP 90-alpha 1.	Pro-epidermal growth factor.	0.464
LOC108257811	egfr	ENSIPUP00000033107	ENSIPUP00000015198	Heat shock protein HSP 90-alpha 1.	Receptor protein-tyrosine kinase.	0.588
LOC108257811	erbb3	ENSIPUP00000033107	ENSIPUP00000029116	Heat shock protein HSP 90-alpha 1.	Receptor tyrosine-protein kinase erbB-3 isoform X2.	0.588
LOC108257811	erbb4	ENSIPUP00000033107	ENSIPUP00000011568	Heat shock protein HSP 90-alpha 1.	Receptor protein-tyrosine kinase.	0.588
LOC108257811	rps27a	ENSIPUP00000033107	ENSIPUP00000022626	Heat shock protein HSP 90-alpha 1.	Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...]	0.625
LOC108257811	stub1	ENSIPUP00000033107	ENSIPUP00000006488	Heat shock protein HSP 90-alpha 1.	E3 ubiquitin-protein ligase CHIP isoform X2.	0.891
LOC108257811	uba52	ENSIPUP00000033107	ENSIPUP00000007381	Heat shock protein HSP 90-alpha 1.	ubiquitin-60S ribosomal protein L40 isoform X1.	0.563