33 items (Ictalurus punctatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ccnt1	cyclin-T1 isoform X2; Belongs to the cyclin family. (495 aa)
	tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family. (376 aa)
	cdk6	Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (323 aa)
	ccnj	cyclin-J; Belongs to the cyclin family. (366 aa)
	ccnc	cyclin-C isoform X1; Belongs to the cyclin family. (283 aa)
	ccnd3	G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (278 aa)
	ccnb1	G2/mitotic-specific cyclin-B1 isoform X2; Belongs to the cyclin family. (401 aa)
	ccna2	cyclin-A2; Belongs to the cyclin family. (423 aa)
	cdk1	Cyclin-dependent kinase 1 isoform X1; Belongs to the protein kinase superfamily. (302 aa)
	ttr	Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. (155 aa)
	cdk17	Cyclin-dependent kinase 17. (543 aa)
	ccnd1	G1/S-specific cyclin-D1; Belongs to the cyclin family. (292 aa)
	ccnt2	cyclin-T2; Belongs to the cyclin family. (558 aa)
	cdk20	Cyclin-dependent kinase 20 isoform X1; Belongs to the protein kinase superfamily. (347 aa)
	cdk2	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (301 aa)
	cdk16	Cyclin-dependent kinase 16 isoform X1. (545 aa)
	cdk12	Cyclin-dependent kinase 12. (1281 aa)
	cables1	CDK5 and ABL1 enzyme substrate 1 isoform X1. (523 aa)
	cdk8	Cyclin-dependent kinase 8; Belongs to the protein kinase superfamily. (470 aa)
	ccna1	cyclin-A1 isoform X2; Belongs to the cyclin family. (397 aa)
	cables2	CDK5 and ABL1 enzyme substrate 2; Belongs to the cyclin family. (480 aa)
	cdk14	Cyclin-dependent kinase 14 isoform X1; Belongs to the protein kinase superfamily. (451 aa)
	cdk10	Cyclin-dependent kinase 10; Belongs to the protein kinase superfamily. (268 aa)
	LOC108254840	Cyclin-dependent kinase 18-like; Belongs to the protein kinase superfamily. (466 aa)
	ccnk	cyclin-K; Belongs to the cyclin family. (490 aa)
	LOC108266529	cyclin-T2-like isoform X5; Belongs to the cyclin family. (617 aa)
	cdk7	Cell division protein kinase 7; Belongs to the protein kinase superfamily. (345 aa)
	cdk15	Cyclin-dependent kinase 15 isoform X1; Belongs to the protein kinase superfamily. (454 aa)
	LOC108279348	Cyclin-dependent kinase 9-like; Belongs to the protein kinase superfamily. (394 aa)
	LOC108279315	Cyclin-dependent kinase 9 isoform X1; Belongs to the protein kinase superfamily. (394 aa)
	cdk5	Cell division protein kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	cdk13	Cyclin-dependent kinase 13. (1358 aa)
	ccny	cyclin-Y; Belongs to the cyclin family. (349 aa)

Your Current Organism:

Ictalurus punctatus

NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC108254840	LOC108266529	ENSIPUP00000006125	ENSIPUP00000002890	Cyclin-dependent kinase 18-like; Belongs to the protein kinase superfamily.	cyclin-T2-like isoform X5; Belongs to the cyclin family.	0.478
LOC108254840	cables1	ENSIPUP00000006125	ENSIPUP00000015574	Cyclin-dependent kinase 18-like; Belongs to the protein kinase superfamily.	CDK5 and ABL1 enzyme substrate 1 isoform X1.	0.587
LOC108254840	cables2	ENSIPUP00000006125	ENSIPUP00000013346	Cyclin-dependent kinase 18-like; Belongs to the protein kinase superfamily.	CDK5 and ABL1 enzyme substrate 2; Belongs to the cyclin family.	0.589
LOC108254840	ccna1	ENSIPUP00000006125	ENSIPUP00000014172	Cyclin-dependent kinase 18-like; Belongs to the protein kinase superfamily.	cyclin-A1 isoform X2; Belongs to the cyclin family.	0.798
LOC108254840	ccna2	ENSIPUP00000006125	ENSIPUP00000024425	Cyclin-dependent kinase 18-like; Belongs to the protein kinase superfamily.	cyclin-A2; Belongs to the cyclin family.	0.798
LOC108254840	ccnb1	ENSIPUP00000006125	ENSIPUP00000024746	Cyclin-dependent kinase 18-like; Belongs to the protein kinase superfamily.	G2/mitotic-specific cyclin-B1 isoform X2; Belongs to the cyclin family.	0.757
LOC108254840	ccnc	ENSIPUP00000006125	ENSIPUP00000025904	Cyclin-dependent kinase 18-like; Belongs to the protein kinase superfamily.	cyclin-C isoform X1; Belongs to the cyclin family.	0.483
LOC108254840	ccnd1	ENSIPUP00000006125	ENSIPUP00000021514	Cyclin-dependent kinase 18-like; Belongs to the protein kinase superfamily.	G1/S-specific cyclin-D1; Belongs to the cyclin family.	0.692
LOC108254840	ccnd3	ENSIPUP00000006125	ENSIPUP00000025881	Cyclin-dependent kinase 18-like; Belongs to the protein kinase superfamily.	G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family.	0.700
LOC108254840	ccnj	ENSIPUP00000006125	ENSIPUP00000027732	Cyclin-dependent kinase 18-like; Belongs to the protein kinase superfamily.	cyclin-J; Belongs to the cyclin family.	0.765
LOC108254840	ccnk	ENSIPUP00000006125	ENSIPUP00000003202	Cyclin-dependent kinase 18-like; Belongs to the protein kinase superfamily.	cyclin-K; Belongs to the cyclin family.	0.433
LOC108254840	ccnt1	ENSIPUP00000006125	ENSIPUP00000033062	Cyclin-dependent kinase 18-like; Belongs to the protein kinase superfamily.	cyclin-T1 isoform X2; Belongs to the cyclin family.	0.478
LOC108254840	ccnt2	ENSIPUP00000006125	ENSIPUP00000020424	Cyclin-dependent kinase 18-like; Belongs to the protein kinase superfamily.	cyclin-T2; Belongs to the cyclin family.	0.478
LOC108254840	ccny	ENSIPUP00000006125	ENSIPUP00000000964	Cyclin-dependent kinase 18-like; Belongs to the protein kinase superfamily.	cyclin-Y; Belongs to the cyclin family.	0.650
LOC108254840	cdk10	ENSIPUP00000006125	ENSIPUP00000010964	Cyclin-dependent kinase 18-like; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase 10; Belongs to the protein kinase superfamily.	0.467
LOC108254840	cdk20	ENSIPUP00000006125	ENSIPUP00000019444	Cyclin-dependent kinase 18-like; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase 20 isoform X1; Belongs to the protein kinase superfamily.	0.639
LOC108254840	cdk7	ENSIPUP00000006125	ENSIPUP00000028801	Cyclin-dependent kinase 18-like; Belongs to the protein kinase superfamily.	Cell division protein kinase 7; Belongs to the protein kinase superfamily.	0.638
LOC108254840	tp53	ENSIPUP00000006125	ENSIPUP00000031919	Cyclin-dependent kinase 18-like; Belongs to the protein kinase superfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.	0.441
LOC108266529	LOC108254840	ENSIPUP00000002890	ENSIPUP00000006125	cyclin-T2-like isoform X5; Belongs to the cyclin family.	Cyclin-dependent kinase 18-like; Belongs to the protein kinase superfamily.	0.478
LOC108266529	LOC108279315	ENSIPUP00000002890	ENSIPUP00000031655	cyclin-T2-like isoform X5; Belongs to the cyclin family.	Cyclin-dependent kinase 9 isoform X1; Belongs to the protein kinase superfamily.	0.947