STRINGSTRING
LOC108260860 LOC108260860 tp53 tp53 scin scin gpx8 gpx8 LOC108255192 LOC108255192 sod2 sod2 LOC108255606 LOC108255606 LOC108255605 LOC108255605 il10 il10 LOC108265704 LOC108265704 nlrc3 nlrc3 tmbim6 tmbim6 tlr2 tlr2 gpx7 gpx7 LOC108267794 LOC108267794 rpsa rpsa LOC108273566 LOC108273566 gpx3 gpx3 irf7 irf7 LOC100305036 LOC100305036 impdh2 impdh2 impdh1 impdh1 il11 il11 LOC108255504 LOC108255504 pik3c3 pik3c3 LOC108266311 LOC108266311 LOC108272108 LOC108272108 LOC108278897 LOC108278897 LOC108280481 LOC108280481 LOC108259599 LOC108259599 BAX BAX bax bax LOC108273898 LOC108273898 gpx1 gpx1 gpx4 gpx4 GPX2 GPX2 casp3 casp3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC108260860Caspase-3-like; Belongs to the peptidase C14A family. (287 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family. (376 aa)
scinAdseverin. (723 aa)
gpx8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (210 aa)
LOC108255192Glutathione peroxidase; Belongs to the glutathione peroxidase family. (178 aa)
sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (224 aa)
LOC108255606Polyubiquitin-like. (155 aa)
LOC108255605Polyubiquitin-like. (158 aa)
il10Interleukin-10. (223 aa)
LOC108265704Toll-like receptor 9; Belongs to the Toll-like receptor family. (1067 aa)
nlrc3Protein NLRC3. (1145 aa)
tmbim6Putative Bax inhibitor 1; Belongs to the BI1 family. (237 aa)
tlr2Toll-like receptor 2. (790 aa)
gpx7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
LOC108267794Caspase-4-like isoform X1; Belongs to the peptidase C14A family. (453 aa)
rpsa40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Belongs to the universal ribosomal protein uS2 family. (317 aa)
LOC108273566Glutathione peroxidase; Belongs to the glutathione peroxidase family. (137 aa)
gpx3Glutathione peroxidase; Belongs to the glutathione peroxidase family. (210 aa)
irf7Interferon regulatory factor 7. (424 aa)
LOC100305036Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] (649 aa)
impdh2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (538 aa)
impdh1Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (605 aa)
il11Interleukin-11. (195 aa)
LOC108255504Gelsolin-like isoform X1. (730 aa)
pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (918 aa)
LOC108266311Signal transducer and activator of transcription. (780 aa)
LOC108272108Gelsolin-like. (719 aa)
LOC108278897Gelsolin-like. (829 aa)
LOC108280481Gelsolin-like. (772 aa)
LOC108259599Apoptosis regulator BAX-like isoform X1. (203 aa)
BAXBCL2 associated X, apoptosis regulator. (176 aa)
baxApoptosis regulator BAX. (189 aa)
LOC108273898Interferon regulatory factor 3-like. (462 aa)
gpx1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (142 aa)
gpx4Glutathione peroxidase; Belongs to the glutathione peroxidase family. (112 aa)
GPX2Glutathione peroxidase; Belongs to the glutathione peroxidase family. (142 aa)
casp3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (285 aa)
Your Current Organism:
Ictalurus punctatus
NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish
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