22 items (Ictalurus punctatus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	casp9	Caspase-9 isoform X2; Belongs to the peptidase C14A family. (432 aa)
	LOC108273362	Cytochrome C; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
	bax	Apoptosis regulator BAX. (189 aa)
	BAX	BCL2 associated X, apoptosis regulator. (176 aa)
	LOC108259599	Apoptosis regulator BAX-like isoform X1. (203 aa)
	bok	Bcl-2-related ovarian killer protein. (214 aa)
	LOC108261414-6	Histone H3. (136 aa)
	LOC108261414-5	Histone H3. (136 aa)
	LOC108267470	Apoptosis regulator Bcl-2-like. (204 aa)
	LOC108261414-4	Histone H3. (136 aa)
	LOC108261566	Histone H3.3-like. (136 aa)
	LOC108261414-3	Histone H3. (136 aa)
	ENSIPUP00000012377	Histone H3-like. (149 aa)
	b2m	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (117 aa)
	bcl2	Apoptosis regulator Bcl-2. (204 aa)
	LOC108261414-2	Histone H3. (136 aa)
	LOC108261414	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC108262495	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC108264639	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC108260860	Caspase-3-like; Belongs to the peptidase C14A family. (287 aa)
	tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family. (376 aa)
	casp3	Caspase-3 isoform X1; Belongs to the peptidase C14A family. (285 aa)

Your Current Organism:

Ictalurus punctatus

NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAX	LOC108267470	ENSIPUP00000022885	ENSIPUP00000018003	BCL2 associated X, apoptosis regulator.	Apoptosis regulator Bcl-2-like.	0.623
BAX	LOC108273362	ENSIPUP00000022885	ENSIPUP00000027951	BCL2 associated X, apoptosis regulator.	Cytochrome C; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.657
LOC108259599	LOC108267470	ENSIPUP00000021312	ENSIPUP00000018003	Apoptosis regulator BAX-like isoform X1.	Apoptosis regulator Bcl-2-like.	0.902
LOC108259599	LOC108273362	ENSIPUP00000021312	ENSIPUP00000027951	Apoptosis regulator BAX-like isoform X1.	Cytochrome C; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.946
LOC108259599	bcl2	ENSIPUP00000021312	ENSIPUP00000006947	Apoptosis regulator BAX-like isoform X1.	Apoptosis regulator Bcl-2.	0.900
LOC108260860	LOC108267470	ENSIPUP00000034973	ENSIPUP00000018003	Caspase-3-like; Belongs to the peptidase C14A family.	Apoptosis regulator Bcl-2-like.	0.624
LOC108260860	LOC108273362	ENSIPUP00000034973	ENSIPUP00000027951	Caspase-3-like; Belongs to the peptidase C14A family.	Cytochrome C; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.767
LOC108260860	bcl2	ENSIPUP00000034973	ENSIPUP00000006947	Caspase-3-like; Belongs to the peptidase C14A family.	Apoptosis regulator Bcl-2.	0.660
LOC108260860	casp3	ENSIPUP00000034973	ENSIPUP00000030411	Caspase-3-like; Belongs to the peptidase C14A family.	Caspase-3 isoform X1; Belongs to the peptidase C14A family.	0.902
LOC108260860	casp9	ENSIPUP00000034973	ENSIPUP00000028681	Caspase-3-like; Belongs to the peptidase C14A family.	Caspase-9 isoform X2; Belongs to the peptidase C14A family.	0.971
LOC108260860	tp53	ENSIPUP00000034973	ENSIPUP00000031919	Caspase-3-like; Belongs to the peptidase C14A family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.	0.761
LOC108267470	BAX	ENSIPUP00000018003	ENSIPUP00000022885	Apoptosis regulator Bcl-2-like.	BCL2 associated X, apoptosis regulator.	0.623
LOC108267470	LOC108259599	ENSIPUP00000018003	ENSIPUP00000021312	Apoptosis regulator Bcl-2-like.	Apoptosis regulator BAX-like isoform X1.	0.902
LOC108267470	LOC108260860	ENSIPUP00000018003	ENSIPUP00000034973	Apoptosis regulator Bcl-2-like.	Caspase-3-like; Belongs to the peptidase C14A family.	0.624
LOC108267470	LOC108273362	ENSIPUP00000018003	ENSIPUP00000027951	Apoptosis regulator Bcl-2-like.	Cytochrome C; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.888
LOC108267470	bax	ENSIPUP00000018003	ENSIPUP00000022942	Apoptosis regulator Bcl-2-like.	Apoptosis regulator BAX.	0.996
LOC108267470	bcl2	ENSIPUP00000018003	ENSIPUP00000006947	Apoptosis regulator Bcl-2-like.	Apoptosis regulator Bcl-2.	0.981
LOC108267470	casp3	ENSIPUP00000018003	ENSIPUP00000030411	Apoptosis regulator Bcl-2-like.	Caspase-3 isoform X1; Belongs to the peptidase C14A family.	0.561
LOC108267470	casp9	ENSIPUP00000018003	ENSIPUP00000028681	Apoptosis regulator Bcl-2-like.	Caspase-9 isoform X2; Belongs to the peptidase C14A family.	0.823
LOC108267470	tp53	ENSIPUP00000018003	ENSIPUP00000031919	Apoptosis regulator Bcl-2-like.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.	0.902