STRINGSTRING
socs6 socs6 LOC108263495 LOC108263495 mvp mvp LOC108270398 LOC108270398 bcl2 bcl2 LOC108267470 LOC108267470 LOC108273098 LOC108273098 LOC100304635 LOC100304635 LOC108259599 LOC108259599 LOC108273129 LOC108273129 BAX BAX bax bax relb relb casp7 casp7 apaf1 apaf1 LOC108266930 LOC108266930 casp9 casp9 casp3 casp3 tp53 tp53 LOC108260860 LOC108260860 il10 il10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
socs6Suppressor of cytokine signaling 6 isoform X1. (527 aa)
LOC108263495Cyclic AMP-responsive element-binding protein 3-like protein 4. (447 aa)
mvpMajor vault protein; Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport (By similarity). (871 aa)
LOC108270398Forkhead box protein O3-like. (635 aa)
bcl2Apoptosis regulator Bcl-2. (204 aa)
LOC108267470Apoptosis regulator Bcl-2-like. (204 aa)
LOC108273098Caspase-8-like isoform X1; Belongs to the peptidase C14A family. (493 aa)
LOC100304635Caspase 8 isoform X1; Belongs to the peptidase C14A family. (371 aa)
LOC108259599Apoptosis regulator BAX-like isoform X1. (203 aa)
LOC108273129Caspase-8-like; Belongs to the peptidase C14A family. (353 aa)
BAXBCL2 associated X, apoptosis regulator. (176 aa)
baxApoptosis regulator BAX. (189 aa)
relbTranscription factor RelB isoform X1. (557 aa)
casp7Caspase-7 isoform X1; Belongs to the peptidase C14A family. (310 aa)
apaf1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1236 aa)
LOC108266930Caspase-8-like isoform X1; Belongs to the peptidase C14A family. (525 aa)
casp9Caspase-9 isoform X2; Belongs to the peptidase C14A family. (432 aa)
casp3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (285 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family. (376 aa)
LOC108260860Caspase-3-like; Belongs to the peptidase C14A family. (287 aa)
il10Interleukin-10. (223 aa)
Your Current Organism:
Ictalurus punctatus
NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish
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