31 items (Ictalurus punctatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC108258222	NF-kappa-B inhibitor alpha-like. (308 aa)
	LOC108259599	Apoptosis regulator BAX-like isoform X1. (203 aa)
	LOC108273098	Caspase-8-like isoform X1; Belongs to the peptidase C14A family. (493 aa)
	LOC108267470	Apoptosis regulator Bcl-2-like. (204 aa)
	nfkbia	NF-kappa-B inhibitor alpha. (320 aa)
	LOC108266311	Signal transducer and activator of transcription. (780 aa)
	jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1219 aa)
	prkd3	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (884 aa)
	LOC108267736	Casein kinase II subunit alpha-like. (403 aa)
	rap1a	Ras-related protein Rap-1A. (186 aa)
	bcl2	Apoptosis regulator Bcl-2. (204 aa)
	LOC108266036	frizzled-10-B-like; Belongs to the G-protein coupled receptor Fz/Smo family. (589 aa)
	LOC108267794	Caspase-4-like isoform X1; Belongs to the peptidase C14A family. (453 aa)
	ngfr	Tumor necrosis factor receptor superfamily member 16 isoform X1. (378 aa)
	LOC108270251	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (895 aa)
	LOC108259786	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
	ywhaq	14-3-3 protein theta; Belongs to the 14-3-3 family. (244 aa)
	LOC108259964	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
	dvl1	Segment polarity protein dishevelled homolog DVL-1 isoform X1. (730 aa)
	cd40lg	CD40 ligand; Belongs to the tumor necrosis factor family. (262 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2525 aa)
	tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family. (376 aa)
	mapk1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa)
	LOC108276199	Tyrosine-protein kinase. (543 aa)
	apln	Apelin. (189 aa)
	gna12	Guanine nucleotide-binding protein subunit alpha-12. (384 aa)
	traf3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (556 aa)
	traf3ip2	Adapter protein CIKS. (409 aa)
	bax	Apoptosis regulator BAX. (189 aa)
	BAX	BCL2 associated X, apoptosis regulator. (176 aa)
	prkca	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (668 aa)

Your Current Organism:

Ictalurus punctatus

NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAX	LOC108267470	ENSIPUP00000022885	ENSIPUP00000018003	BCL2 associated X, apoptosis regulator.	Apoptosis regulator Bcl-2-like.	0.623
BAX	ywhaq	ENSIPUP00000022885	ENSIPUP00000035029	BCL2 associated X, apoptosis regulator.	14-3-3 protein theta; Belongs to the 14-3-3 family.	0.429
LOC108258222	LOC108273098	ENSIPUP00000022153	ENSIPUP00000020296	NF-kappa-B inhibitor alpha-like.	Caspase-8-like isoform X1; Belongs to the peptidase C14A family.	0.496
LOC108258222	nfkbia	ENSIPUP00000022153	ENSIPUP00000018449	NF-kappa-B inhibitor alpha-like.	NF-kappa-B inhibitor alpha.	0.902
LOC108258222	ngfr	ENSIPUP00000022153	ENSIPUP00000036359	NF-kappa-B inhibitor alpha-like.	Tumor necrosis factor receptor superfamily member 16 isoform X1.	0.411
LOC108258222	tp53	ENSIPUP00000022153	ENSIPUP00000031919	NF-kappa-B inhibitor alpha-like.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.	0.481
LOC108258222	ywhaq	ENSIPUP00000022153	ENSIPUP00000035029	NF-kappa-B inhibitor alpha-like.	14-3-3 protein theta; Belongs to the 14-3-3 family.	0.404
LOC108259599	LOC108267470	ENSIPUP00000021312	ENSIPUP00000018003	Apoptosis regulator BAX-like isoform X1.	Apoptosis regulator Bcl-2-like.	0.902
LOC108259599	bcl2	ENSIPUP00000021312	ENSIPUP00000006947	Apoptosis regulator BAX-like isoform X1.	Apoptosis regulator Bcl-2.	0.900
LOC108259786	LOC108259964	ENSIPUP00000035672	ENSIPUP00000033469	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.900
LOC108259786	mtor	ENSIPUP00000035672	ENSIPUP00000032852	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.484
LOC108259964	LOC108259786	ENSIPUP00000033469	ENSIPUP00000035672	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.900
LOC108259964	mtor	ENSIPUP00000033469	ENSIPUP00000032852	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.488
LOC108266036	dvl1	ENSIPUP00000005661	ENSIPUP00000033052	frizzled-10-B-like; Belongs to the G-protein coupled receptor Fz/Smo family.	Segment polarity protein dishevelled homolog DVL-1 isoform X1.	0.843
LOC108266311	LOC108276199	ENSIPUP00000013538	ENSIPUP00000028135	Signal transducer and activator of transcription.	Tyrosine-protein kinase.	0.427
LOC108266311	mapk1	ENSIPUP00000013538	ENSIPUP00000030101	Signal transducer and activator of transcription.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.408
LOC108267470	BAX	ENSIPUP00000018003	ENSIPUP00000022885	Apoptosis regulator Bcl-2-like.	BCL2 associated X, apoptosis regulator.	0.623
LOC108267470	LOC108259599	ENSIPUP00000018003	ENSIPUP00000021312	Apoptosis regulator Bcl-2-like.	Apoptosis regulator BAX-like isoform X1.	0.902
LOC108267470	LOC108267794	ENSIPUP00000018003	ENSIPUP00000003807	Apoptosis regulator Bcl-2-like.	Caspase-4-like isoform X1; Belongs to the peptidase C14A family.	0.512
LOC108267470	LOC108273098	ENSIPUP00000018003	ENSIPUP00000020296	Apoptosis regulator Bcl-2-like.	Caspase-8-like isoform X1; Belongs to the peptidase C14A family.	0.640