STRINGSTRING
rmi2 rmi2 rpa1 rpa1 brip1 brip1 rmi1 rmi1 LOC113568250 LOC113568250 LOC113569058 LOC113569058 rad51d rad51d DNA2 DNA2 nbn nbn top3a top3a recql4 recql4 rad50 rad50 xrcc3 xrcc3 rad51 rad51 ENSEEEP00000017959 ENSEEEP00000017959 ENSEEEP00000018543 ENSEEEP00000018543 LOC113582267 LOC113582267 exo1 exo1 rpa3 rpa3 mre11 mre11 LOC113589524 LOC113589524 slf1 slf1 ENSEEEP00000032310 ENSEEEP00000032310 rbbp8 rbbp8 blm blm XRCC2 XRCC2 rpa2 rpa2 rad52 rad52 LOC113576847 LOC113576847 bard1 bard1 ENSEEEP00000050839 ENSEEEP00000050839
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rmi2Uncharacterized protein. (147 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (624 aa)
brip1Helicase ATP-binding domain-containing protein. (1220 aa)
rmi1DUF1767 domain-containing protein. (587 aa)
LOC113568250RAD51 paralog C. (260 aa)
LOC113569058AAA_23 domain-containing protein. (469 aa)
rad51dRECA_2 domain-containing protein. (338 aa)
DNA2DNA replication helicase/nuclease 2. (1002 aa)
nbnNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (816 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1009 aa)
recql4RecQ helicase-like 4. (817 aa)
rad50RAD50 homolog, double strand break repair protein. (1181 aa)
xrcc3RECA_2 domain-containing protein. (355 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
ENSEEEP00000017959ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (784 aa)
ENSEEEP00000018543Methionine sulfoxide reductase B1b. (259 aa)
LOC113582267Breast cancer 2, early onset. (2391 aa)
exo1Exonuclease 1. (771 aa)
rpa3Uncharacterized protein. (122 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (667 aa)
LOC113589524RECA_2 domain-containing protein. (121 aa)
slf1ANK_REP_REGION domain-containing protein. (905 aa)
ENSEEEP00000032310ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (3024 aa)
rbbp8SAE2 domain-containing protein. (131 aa)
blmBLM RecQ like helicase. (1281 aa)
XRCC2RECA_2 domain-containing protein. (302 aa)
rpa2RPA_C domain-containing protein. (280 aa)
rad52RAD52 homolog, DNA repair protein. (287 aa)
LOC113576847RING-type domain-containing protein. (995 aa)
bard1BRCA1 associated RING domain 1. (689 aa)
ENSEEEP00000050839Metallophos domain-containing protein. (106 aa)
Your Current Organism:
Electrophorus electricus
NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.