(28 nodes) Polymerase switching, and Epsilon DNA polymerase complex network (Electrophorus electricus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	LOC113571395	Polymerase (DNA directed), epsilon 2. (527 aa)
	pold1	DNA polymerase. (1061 aa)
	rfc4	AAA domain-containing protein. (357 aa)
	pold3	Uncharacterized protein. (462 aa)
	pold4	Uncharacterized protein. (109 aa)
	LOC113571529	DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (509 aa)
	rfc2	AAA domain-containing protein. (369 aa)
	ENSEEEP00000011546	Uncharacterized protein. (890 aa)
	prim1	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (422 aa)
	rfc1	Replication factor C subunit 1. (1124 aa)
	pola1	DNA polymerase. (1321 aa)
	ENSEEEP00000017941	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (304 aa)
	Pole	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (708 aa)
	ENSEEEP00000017953	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (368 aa)
	rfc5	AAA domain-containing protein. (363 aa)
	chtf8	Uncharacterized protein. (124 aa)
	pola2	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (600 aa)
	rfc3	AAA domain-containing protein. (356 aa)
	dscc1	DNA replication and sister chromatid cohesion 1. (395 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	pole4	CBFD_NFYB_HMF domain-containing protein. (127 aa)
	lig1	DNA ligase. (941 aa)
	pole3	CBFD_NFYB_HMF domain-containing protein. (149 aa)
	fen1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
	LOC113590030	Uncharacterized protein. (347 aa)
	chtf18	AAA domain-containing protein. (936 aa)
	rad17	Uncharacterized protein. (683 aa)
	pold2	Uncharacterized protein. (469 aa)

Your Current Organism:

Electrophorus electricus

NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSEEEP00000011546	ENSEEEP00000017941	ENSEEEP00000011546	ENSEEEP00000017941	Uncharacterized protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.777
ENSEEEP00000011546	ENSEEEP00000017953	ENSEEEP00000011546	ENSEEEP00000017953	Uncharacterized protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.777
ENSEEEP00000011546	LOC113571395	ENSEEEP00000011546	ENSEEEP00000000250	Uncharacterized protein.	Polymerase (DNA directed), epsilon 2.	0.795
ENSEEEP00000011546	LOC113571529	ENSEEEP00000011546	ENSEEEP00000008213	Uncharacterized protein.	DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.	0.854
ENSEEEP00000011546	LOC113590030	ENSEEEP00000011546	ENSEEEP00000033260	Uncharacterized protein.	Uncharacterized protein.	0.909
ENSEEEP00000011546	Pole	ENSEEEP00000011546	ENSEEEP00000017944	Uncharacterized protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.777
ENSEEEP00000011546	chtf18	ENSEEEP00000011546	ENSEEEP00000034171	Uncharacterized protein.	AAA domain-containing protein.	0.908
ENSEEEP00000011546	chtf8	ENSEEEP00000011546	ENSEEEP00000021030	Uncharacterized protein.	Uncharacterized protein.	0.733
ENSEEEP00000011546	dscc1	ENSEEEP00000011546	ENSEEEP00000026867	Uncharacterized protein.	DNA replication and sister chromatid cohesion 1.	0.858
ENSEEEP00000011546	fen1	ENSEEEP00000011546	ENSEEEP00000032875	Uncharacterized protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.909
ENSEEEP00000011546	lig1	ENSEEEP00000011546	ENSEEEP00000030950	Uncharacterized protein.	DNA ligase.	0.858
ENSEEEP00000011546	pcna	ENSEEEP00000011546	ENSEEEP00000028033	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.980
ENSEEEP00000011546	pola1	ENSEEEP00000011546	ENSEEEP00000016683	Uncharacterized protein.	DNA polymerase.	0.879
ENSEEEP00000011546	pola2	ENSEEEP00000011546	ENSEEEP00000022425	Uncharacterized protein.	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	0.881
ENSEEEP00000011546	pold1	ENSEEEP00000011546	ENSEEEP00000002302	Uncharacterized protein.	DNA polymerase.	0.836
ENSEEEP00000011546	pold2	ENSEEEP00000011546	ENSEEEP00000040348	Uncharacterized protein.	Uncharacterized protein.	0.721
ENSEEEP00000011546	pold3	ENSEEEP00000011546	ENSEEEP00000005809	Uncharacterized protein.	Uncharacterized protein.	0.703
ENSEEEP00000011546	pole3	ENSEEEP00000011546	ENSEEEP00000031747	Uncharacterized protein.	CBFD_NFYB_HMF domain-containing protein.	0.787
ENSEEEP00000011546	pole4	ENSEEEP00000011546	ENSEEEP00000030341	Uncharacterized protein.	CBFD_NFYB_HMF domain-containing protein.	0.691
ENSEEEP00000011546	prim1	ENSEEEP00000011546	ENSEEEP00000013599	Uncharacterized protein.	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.821