STRINGSTRING
nbn nbn lrwd1 lrwd1 rif1 rif1 rad51d rad51d ten1 ten1 ENSEEEP00000007003 ENSEEEP00000007003 ENSEEEP00000006834 ENSEEEP00000006834 LOC113569058 LOC113569058 LOC113589886 LOC113589886 sirt6 sirt6 ENSEEEP00000014239 ENSEEEP00000014239 LOC113592198 LOC113592198 rad50 rad50 spo11 spo11 kdm1a kdm1a dclre1b dclre1b rad51 rad51 orc1 orc1 atrx atrx LOC113582267 LOC113582267 pot1 pot1 ENSEEEP00000019307 ENSEEEP00000019307 ENSEEEP00000014236 ENSEEEP00000014236 pinx1 pinx1 orc4 orc4 ercc4 ercc4 terf2ip terf2ip dmc1 dmc1 smc5 smc5 dhx36 dhx36 rnf8 rnf8 xrcc1 xrcc1 ENSEEEP00000032310 ENSEEEP00000032310 wrap53 wrap53 nsmce2 nsmce2 tnks tnks ENSEEEP00000034928 ENSEEEP00000034928 tert tert LOC113567536 LOC113567536 ENSEEEP00000035972 ENSEEEP00000035972 smg6 smg6 LOC113567594 LOC113567594 TNKS2 TNKS2 terb2 terb2 hat1 hat1 ercc1 ercc1 zbtb48 zbtb48 ENSEEEP00000043857 ENSEEEP00000043857 xrcc5 xrcc5 orc2 orc2 nsmce4a nsmce4a ENSEEEP00000049623 ENSEEEP00000049623 LOC113588689 LOC113588689 stn1 stn1 ENSEEEP00000050839 ENSEEEP00000050839 pold1 pold1 nsmce1 nsmce1 ENSEEEP00000000428 ENSEEEP00000000428 mre11 mre11 ENSEEEP00000011836 ENSEEEP00000011836 LOC113578292 LOC113578292 recql4 recql4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
nbnNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (816 aa)
lrwd1Leucine-rich repeats and WD repeat domain containing 1. (783 aa)
rif1Replication timing regulatory factor 1. (2379 aa)
rad51dRECA_2 domain-containing protein. (338 aa)
ten1TEN1 CST complex subunit. (140 aa)
ENSEEEP00000007003AAA_23 domain-containing protein. (53 aa)
ENSEEEP00000006834Uncharacterized protein. (110 aa)
LOC113569058AAA_23 domain-containing protein. (469 aa)
LOC113589886Poly [ADP-ribose] polymerase. (1168 aa)
sirt6Deacetylase sirtuin-type domain-containing protein. (396 aa)
ENSEEEP00000014239Uncharacterized protein. (333 aa)
LOC113592198Uncharacterized protein. (632 aa)
rad50RAD50 homolog, double strand break repair protein. (1181 aa)
spo11SPO11 meiotic protein covalently bound to DSB. (368 aa)
kdm1aLysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (859 aa)
dclre1bDNA cross-link repair 1B. (580 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (893 aa)
atrxUncharacterized protein. (1986 aa)
LOC113582267Breast cancer 2, early onset. (2391 aa)
pot1Protection of telomeres 1 homolog. (767 aa)
ENSEEEP00000019307Uncharacterized protein. (258 aa)
ENSEEEP00000014236Uncharacterized protein. (328 aa)
pinx1PIN2 (TERF1) interacting telomerase inhibitor 1. (181 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (472 aa)
ercc4ERCC4 domain-containing protein. (899 aa)
terf2ipTelomeric repeat binding factor 2, interacting protein. (536 aa)
dmc1DNA meiotic recombinase 1. (324 aa)
smc5Structural maintenance of chromosomes 5. (1083 aa)
dhx36DEAH (Asp-Glu-Ala-His) box polypeptide 36. (1001 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (484 aa)
xrcc1X-ray repair complementing defective repair in Chinese hamster cells 1. (539 aa)
ENSEEEP00000032310ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (3024 aa)
wrap53WD repeat containing, antisense to TP53. (519 aa)
nsmce2NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (257 aa)
tnksPoly [ADP-ribose] polymerase. (1274 aa)
ENSEEEP00000034928Uncharacterized protein. (435 aa)
tertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1062 aa)
LOC113567536Uncharacterized protein. (1086 aa)
ENSEEEP00000035972Zinc finger protein 827. (680 aa)
smg6SMG6 nonsense mediated mRNA decay factor. (1575 aa)
LOC113567594Si:dkey-119f1.1. (1009 aa)
TNKS2Poly [ADP-ribose] polymerase. (1102 aa)
terb2Telomere repeat binding bouquet formation protein 2. (184 aa)
hat1Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (437 aa)
ercc1Uncharacterized protein. (346 aa)
zbtb48Zinc finger and BTB domain containing 48. (596 aa)
ENSEEEP00000043857Telomeric repeat binding factor a. (471 aa)
xrcc5Ku domain-containing protein. (740 aa)
orc2Origin recognition complex, subunit 2. (491 aa)
nsmce4aNon-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (358 aa)
ENSEEEP00000049623Uncharacterized protein. (81 aa)
LOC113588689Nucleic acid binding protein 2. (156 aa)
stn1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (369 aa)
ENSEEEP00000050839Metallophos domain-containing protein. (106 aa)
pold1DNA polymerase. (1061 aa)
nsmce1zf-RING-like domain-containing protein. (274 aa)
ENSEEEP00000000428Uncharacterized protein. (383 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (667 aa)
ENSEEEP00000011836Homeobox containing 1a. (375 aa)
LOC113578292TINF2_N domain-containing protein. (598 aa)
recql4RecQ helicase-like 4. (817 aa)
Your Current Organism:
Electrophorus electricus
NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish
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