STRINGSTRING
blm blm LOC113578936 LOC113578936 mms22l mms22l ercc4 ercc4 cdc45 cdc45 dmc1 dmc1 top1 top1 mcm4 mcm4 ssbp3 ssbp3 rpa3 rpa3 lonp1 lonp1 dhx36 dhx36 tsn tsn ENSEEEP00000025333 ENSEEEP00000025333 ENSEEEP00000025534 ENSEEEP00000025534 smc4 smc4 polr2h polr2h polr3c polr3c Ercc5 Ercc5 ENSEEEP00000027215 ENSEEEP00000027215 LOC113586875 LOC113586875 recql recql LOC113589623 LOC113589623 myef2 myef2 bivm bivm rad51ap1 rad51ap1 rbbp8 rbbp8 mcm8 mcm8 LOC113584712 LOC113584712 msh2 msh2 fubp3 fubp3 LOC113567584 LOC113567584 LOC113584242 LOC113584242 fbh1 fbh1 ENSEEEP00000038072 ENSEEEP00000038072 ENSEEEP00000038076 ENSEEEP00000038076 LOC113575219 LOC113575219 ercc1 ercc1 mcm7 mcm7 rexo4 rexo4 ssbp1 ssbp1 ENSEEEP00000043857 ENSEEEP00000043857 xpc xpc smarcal1 smarcal1 nup35 nup35 ighmbp2 ighmbp2 polr2g polr2g rad52 rad52 mcm6 mcm6 rtf1 rtf1 LOC113572244 LOC113572244 LOC113588689 LOC113588689 stn1 stn1 mcm2 mcm2 LOC113573002 LOC113573002 rad18 rad18 rad51 rad51 smc2 smc2 ENSEEEP00000018543 ENSEEEP00000018543 zranb3 zranb3 LOC113575331 LOC113575331 ENSEEEP00000000428 ENSEEEP00000000428 LOC113585995 LOC113585995 rpa1 rpa1 samhd1 samhd1 LOC113584344 LOC113584344 LOC113575351 LOC113575351 ENSEEEP00000005499 ENSEEEP00000005499 LOC113569058 LOC113569058 ENSEEEP00000006834 ENSEEEP00000006834 hrob hrob ENSEEEP00000007003 ENSEEEP00000007003 ten1 ten1 hmces hmces sprtn sprtn rad51d rad51d dhx9 dhx9 top3a top3a mcm3 mcm3 recql4 recql4 twnk twnk tdp1 tdp1 neil3 neil3 LOC113592198 LOC113592198 LOC113580497 LOC113580497 rad50 rad50 LRPPRC LRPPRC mcm9 mcm9 LOC113582267 LOC113582267 mcm10 mcm10 mcm5 mcm5 pola1 pola1 pot1 pot1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
blmBLM RecQ like helicase. (1281 aa)
LOC113578936Uncharacterized protein. (296 aa)
mms22lUncharacterized protein. (1240 aa)
ercc4ERCC4 domain-containing protein. (899 aa)
cdc45Uncharacterized protein. (574 aa)
dmc1DNA meiotic recombinase 1. (324 aa)
top1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (725 aa)
mcm4DNA helicase; Belongs to the MCM family. (848 aa)
ssbp3LisH domain-containing protein. (366 aa)
rpa3Uncharacterized protein. (122 aa)
lonp1Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. (980 aa)
dhx36DEAH (Asp-Glu-Ala-His) box polypeptide 36. (1001 aa)
tsnUncharacterized protein. (227 aa)
ENSEEEP00000025333Topoisom_I_N domain-containing protein. (150 aa)
ENSEEEP00000025534Uncharacterized protein. (256 aa)
smc4Structural maintenance of chromosomes protein. (1296 aa)
polr2hDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
polr3cRNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (543 aa)
Ercc5XPGI domain-containing protein. (396 aa)
ENSEEEP00000027215XPGN domain-containing protein. (302 aa)
LOC113586875LisH domain-containing protein. (371 aa)
recqlATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (826 aa)
LOC113589623TOPEUc domain-containing protein. (296 aa)
myef2Myelin expression factor 2. (518 aa)
bivmUncharacterized protein. (505 aa)
rad51ap1RAD51_interact domain-containing protein. (230 aa)
rbbp8SAE2 domain-containing protein. (131 aa)
mcm8MCM domain-containing protein; Belongs to the MCM family. (844 aa)
LOC113584712Uncharacterized protein. (812 aa)
msh2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (939 aa)
fubp3Uncharacterized protein. (595 aa)
LOC113567584Uncharacterized protein. (377 aa)
LOC113584242WD_REPEATS_REGION domain-containing protein. (719 aa)
fbh1F-box domain-containing protein. (1043 aa)
ENSEEEP00000038072LisH domain-containing protein. (76 aa)
ENSEEEP00000038076Uncharacterized protein. (68 aa)
LOC113575219Uncharacterized protein. (287 aa)
ercc1Uncharacterized protein. (346 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (732 aa)
rexo4Exonuclease domain-containing protein. (432 aa)
ssbp1Uncharacterized protein. (149 aa)
ENSEEEP00000043857Telomeric repeat binding factor a. (471 aa)
xpcUncharacterized protein. (868 aa)
smarcal1Uncharacterized protein; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (884 aa)
nup35Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family. (336 aa)
ighmbp2Uncharacterized protein. (1008 aa)
polr2gS1 domain-containing protein. (172 aa)
rad52RAD52 homolog, DNA repair protein. (287 aa)
mcm6DNA helicase; Belongs to the MCM family. (830 aa)
rtf1Plus3 domain-containing protein. (678 aa)
LOC113572244Endo/exonuclease/phosphatase domain-containing protein. (409 aa)
LOC113588689Nucleic acid binding protein 2. (156 aa)
stn1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (369 aa)
mcm2DNA helicase; Belongs to the MCM family. (908 aa)
LOC113573002WD_REPEATS_REGION domain-containing protein. (682 aa)
rad18RAD18 E3 ubiquitin protein ligase. (459 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
smc2Structural maintenance of chromosomes protein. (1219 aa)
ENSEEEP00000018543Methionine sulfoxide reductase B1b. (259 aa)
zranb3Zinc finger, RAN-binding domain containing 3. (1057 aa)
LOC113575331Nucleic acid binding protein 1b. (203 aa)
ENSEEEP00000000428Uncharacterized protein. (383 aa)
LOC113585995DNA helicase; Belongs to the MCM family. (801 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (624 aa)
samhd1Uncharacterized protein. (623 aa)
LOC113584344DNA helicase; Belongs to the MCM family. (820 aa)
LOC113575351Uncharacterized protein. (215 aa)
ENSEEEP00000005499LisH domain-containing protein. (53 aa)
LOC113569058AAA_23 domain-containing protein. (469 aa)
ENSEEEP00000006834Uncharacterized protein. (110 aa)
hrobSi:dkey-260c8.8. (375 aa)
ENSEEEP00000007003AAA_23 domain-containing protein. (53 aa)
ten1TEN1 CST complex subunit. (140 aa)
hmcesAbasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (362 aa)
sprtnSprT-like N-terminal domain. (478 aa)
rad51dRECA_2 domain-containing protein. (338 aa)
dhx9Uncharacterized protein. (1220 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1009 aa)
mcm3DNA helicase; Belongs to the MCM family. (815 aa)
recql4RecQ helicase-like 4. (817 aa)
twnkSF4 helicase domain-containing protein. (135 aa)
tdp1Uncharacterized protein. (622 aa)
neil3Nei-like DNA glycosylase 3. (549 aa)
LOC113592198Uncharacterized protein. (632 aa)
LOC113580497Si:ch211-130m23.3. (343 aa)
rad50RAD50 homolog, double strand break repair protein. (1181 aa)
LRPPRCPPR_long domain-containing protein. (1439 aa)
mcm9MCM domain-containing protein; Belongs to the MCM family. (1143 aa)
LOC113582267Breast cancer 2, early onset. (2391 aa)
mcm10Mcm10 domain-containing protein. (838 aa)
mcm5DNA helicase; Belongs to the MCM family. (738 aa)
pola1DNA polymerase. (1321 aa)
pot1Protection of telomeres 1 homolog. (767 aa)
Your Current Organism:
Electrophorus electricus
NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish
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