Your Input: | |
| | LOC113569503 | Uncharacterized protein. (225 aa) |
| | rmi2 | Uncharacterized protein. (147 aa) |
| | LOC113589927 | Uncharacterized protein. (414 aa) |
| | LOC113585995 | DNA helicase; Belongs to the MCM family. (801 aa) |
| | nsmce1 | zf-RING-like domain-containing protein. (274 aa) |
| | rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (624 aa) |
| | samhd1 | Uncharacterized protein. (623 aa) |
| | smchd1 | Structural maintenance of chromosomes flexible hinge domain containing 1. (1984 aa) |
| | exd2 | Exonuclease 3'-5' domain containing 2. (616 aa) |
| | LOC113584344 | DNA helicase; Belongs to the MCM family. (820 aa) |
| | actr8 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (636 aa) |
| | LOC113575351 | Uncharacterized protein. (215 aa) |
| | ercc6 | Excision repair cross-complementation group 6. (1398 aa) |
| | rmi1 | DUF1767 domain-containing protein. (587 aa) |
| | LOC113568250 | RAD51 paralog C. (260 aa) |
| | sirt6 | Deacetylase sirtuin-type domain-containing protein. (396 aa) |
| | ENSEEEP00000004636 | Rad21_Rec8 domain-containing protein. (66 aa) |
| | ENSEEEP00000004640 | Rad21_Rec8_N domain-containing protein. (138 aa) |
| | LOC113584930 | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (141 aa) |
| | ENSEEEP00000005036 | Uncharacterized protein. (813 aa) |
| | LOC113569058 | AAA_23 domain-containing protein. (469 aa) |
| | LOC113578819 | Uncharacterized protein. (638 aa) |
| | cdca5 | Uncharacterized protein. (260 aa) |
| | ENSEEEP00000006834 | Uncharacterized protein. (110 aa) |
| | ENSEEEP00000007003 | AAA_23 domain-containing protein. (53 aa) |
| | hmces | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (362 aa) |
| | polq | Polymerase (DNA directed), theta. (2580 aa) |
| | dclre1c | DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae). (683 aa) |
| | lig3 | DNA ligase. (1009 aa) |
| | rad51d | RECA_2 domain-containing protein. (338 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1002 aa) |
| | dtx3 | RING-type domain-containing protein. (367 aa) |
| | nbn | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (816 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1009 aa) |
| | mcm3 | DNA helicase; Belongs to the MCM family. (815 aa) |
| | recql4 | RecQ helicase-like 4. (817 aa) |
| | MARF1 | Meiosis regulator and mRNA stability factor 1. (1669 aa) |
| | tdp1 | Uncharacterized protein. (622 aa) |
| | poln | Polymerase (DNA directed) nu. (844 aa) |
| | babam2 | Uncharacterized protein. (442 aa) |
| | dclre1a | DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae). (951 aa) |
| | dntt | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (499 aa) |
| | zswim7 | SWIM-type domain-containing protein. (145 aa) |
| | rad50 | RAD50 homolog, double strand break repair protein. (1181 aa) |
| | spo11 | SPO11 meiotic protein covalently bound to DSB. (368 aa) |
| | mcm9 | MCM domain-containing protein; Belongs to the MCM family. (1143 aa) |
| | LOC113572579 | Intermediate filament family orphan 1a; Belongs to the intermediate filament family. (613 aa) |
| | mlh1 | DNA_mis_repair domain-containing protein. (724 aa) |
| | mcm5 | DNA helicase; Belongs to the MCM family. (738 aa) |
| | xrcc3 | RECA_2 domain-containing protein. (355 aa) |
| | ENSEEEP00000016610 | Histone PARylation factor 1. (176 aa) |
| | dclre1b | DNA cross-link repair 1B. (580 aa) |
| | pola1 | DNA polymerase. (1321 aa) |
| | ENSEEEP00000016716 | Helicase ATP-binding domain-containing protein. (320 aa) |
| | LOC113591245 | Uncharacterized protein. (743 aa) |
| | ENSEEEP00000017093 | Intermediate filament family orphan 2a; Belongs to the intermediate filament family. (459 aa) |
| | rad51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | Rev3l | DNA_pol_B domain-containing protein. (304 aa) |
| | ENSEEEP00000018543 | Methionine sulfoxide reductase B1b. (259 aa) |
| | LOC113582267 | Breast cancer 2, early onset. (2391 aa) |
| | LOC113578445 | RAD21 cohesin complex component b. (620 aa) |
| | paxx | Uncharacterized protein. (192 aa) |
| | ENSEEEP00000019307 | Uncharacterized protein. (258 aa) |
| | nipbl | Nipped-B protein. (2652 aa) |
| | mcm8 | MCM domain-containing protein; Belongs to the MCM family. (844 aa) |
| | LOC113578936 | Uncharacterized protein. (296 aa) |
| | mms22l | Uncharacterized protein. (1240 aa) |
| | MCMDC2 | Minichromosome maintenance domain containing 2. (372 aa) |
| | ercc4 | ERCC4 domain-containing protein. (899 aa) |
| | trip13 | Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (423 aa) |
| | cdc45 | Uncharacterized protein. (574 aa) |
| | dmc1 | DNA meiotic recombinase 1. (324 aa) |
| | swi5 | SWI5 homologous recombination repair protein. (140 aa) |
| | spidr | DUF4503 domain-containing protein. (573 aa) |
| | mcm4 | DNA helicase; Belongs to the MCM family. (848 aa) |
| | cdc7 | Protein kinase domain-containing protein. (555 aa) |
| | xrcc6 | Uncharacterized protein. (627 aa) |
| | smc5 | Structural maintenance of chromosomes 5. (1083 aa) |
| | ercc8 | WD_REPEATS_REGION domain-containing protein. (400 aa) |
| | rpa3 | Uncharacterized protein. (122 aa) |
| | hsf2bp | Heat shock transcription factor 2 binding protein. (329 aa) |
| | lig4 | DNA ligase. (909 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (667 aa) |
| | gins4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (224 aa) |
| | fancb | Uncharacterized protein. (822 aa) |
| | parp2 | Poly [ADP-ribose] polymerase. (572 aa) |
| | ino80 | Uncharacterized protein. (1128 aa) |
| | poll | Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family. (585 aa) |
| | LOC113572403 | Intermediate filament family orphan 2b; Belongs to the intermediate filament family. (476 aa) |
| | rnf8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (484 aa) |
| | uvrag | UV radiation resistance associated gene. (685 aa) |
| | LOC113589524 | RECA_2 domain-containing protein. (121 aa) |
| | recql | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (826 aa) |
| | actr5 | Uncharacterized protein; Belongs to the actin family. (646 aa) |
| | parp1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1012 aa) |
| | xrcc1 | X-ray repair complementing defective repair in Chinese hamster cells 1. (539 aa) |
| | babam1 | Uncharacterized protein. (359 aa) |
| | psmd14 | MPN domain-containing protein. (330 aa) |
| | helq | Uncharacterized protein. (1026 aa) |
| | abraxas1 | MPN domain-containing protein. (419 aa) |
| | polb | DNA_pol_B_thumb domain-containing protein. (54 aa) |
| | ENSEEEP00000032310 | ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (3024 aa) |
| | Meioc | Uncharacterized protein. (221 aa) |
| | Aunip | Uncharacterized protein. (237 aa) |
| | rec8 | REC8 meiotic recombination protein b. (439 aa) |
| | nsmce2 | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (257 aa) |
| | LOC113591806 | Nipped-B protein. (2259 aa) |
| | rad51ap1 | RAD51_interact domain-containing protein. (230 aa) |
| | rbbp8 | SAE2 domain-containing protein. (131 aa) |
| | blm | BLM RecQ like helicase. (1281 aa) |
| | ENSEEEP00000035317 | Zgc:165656. (272 aa) |
| | msh2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (939 aa) |
| | ankle1 | Zgc:85936. (862 aa) |
| | gins2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (182 aa) |
| | LOC113575160 | Uncharacterized protein. (757 aa) |
| | Recql5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (970 aa) |
| | ENSEEEP00000037634 | ERCC4 domain-containing protein. (1166 aa) |
| | ENSEEEP00000037636 | Helicase C-terminal domain-containing protein. (432 aa) |
| | LOC113567584 | Uncharacterized protein. (377 aa) |
| | LOC113584242 | WD_REPEATS_REGION domain-containing protein. (719 aa) |
| | fbh1 | F-box domain-containing protein. (1043 aa) |
| | LOC113575219 | Uncharacterized protein. (287 aa) |
| | LOC113577337 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (263 aa) |
| | XRCC2 | RECA_2 domain-containing protein. (302 aa) |
| | ppp4c | Serine/threonine-protein phosphatase. (307 aa) |
| | ercc1 | Uncharacterized protein. (346 aa) |
| | mcm7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (732 aa) |
| | mus81 | MUS81 structure-specific endonuclease subunit. (615 aa) |
| | hus1 | Checkpoint protein; Belongs to the HUS1 family. (283 aa) |
| | brcc3 | BRCA1/BRCA2-containing complex, subunit 3. (269 aa) |
| | ddx1 | Uncharacterized protein. (740 aa) |
| | ENSEEEP00000043756 | XPGI domain-containing protein. (341 aa) |
| | uimc1 | RAP80_UIM domain-containing protein. (953 aa) |
| | xrcc5 | Ku domain-containing protein. (740 aa) |
| | tonsl | Tonsoku-like, DNA repair protein. (1431 aa) |
| | LOC113591992 | Histone PARylation factor 1. (243 aa) |
| | iffo1 | IF rod domain-containing protein; Belongs to the intermediate filament family. (633 aa) |
| | LOC113592019 | Zgc:136908; Belongs to the AAA ATPase family. (806 aa) |
| | xrcc4 | Uncharacterized protein. (343 aa) |
| | polm | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (503 aa) |
| | rad52 | RAD52 homolog, DNA repair protein. (287 aa) |
| | sem1 | Uncharacterized protein. (70 aa) |
| | vcp | Uncharacterized protein; Belongs to the AAA ATPase family. (806 aa) |
| | mfsd11 | Major facilitator superfamily domain containing 11. (455 aa) |
| | LOC113576847 | RING-type domain-containing protein. (995 aa) |
| | chek2 | Uncharacterized protein. (526 aa) |
| | mcm6 | DNA helicase; Belongs to the MCM family. (830 aa) |
| | fan1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1005 aa) |
| | zfyve26 | Zinc finger, FYVE domain containing 26. (2547 aa) |
| | LOC113572244 | Endo/exonuclease/phosphatase domain-containing protein. (409 aa) |
| | LOC113581998 | RING-type domain-containing protein. (726 aa) |
| | Rnf169 | RING-type domain-containing protein. (106 aa) |
| | LOC113588689 | Nucleic acid binding protein 2. (156 aa) |
| | mcm2 | DNA helicase; Belongs to the MCM family. (908 aa) |
| | pnkp | FHA_2 domain-containing protein. (595 aa) |
| | rnf168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (471 aa) |
| | LOC113573002 | WD_REPEATS_REGION domain-containing protein. (682 aa) |
| | prpf19 | Pre-mRNA processing factor 19. (499 aa) |
| | ENSEEEP00000050839 | Metallophos domain-containing protein. (106 aa) |
| | ENSEEEP00000051054 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (307 aa) |
| | eme1 | Essential meiotic structure-specific endonuclease 1. (550 aa) |
| | fancd2 | FA complementation group D2. (1261 aa) |
| | parp3 | Poly [ADP-ribose] polymerase. (527 aa) |
| | prkdc | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4099 aa) |
| | ap5z1 | Adaptor related protein complex 5 subunit zeta 1. (668 aa) |
| | ap5s1 | Uncharacterized protein. (200 aa) |
| | LOC113589545 | RING-type domain-containing protein. (436 aa) |
| | LOC113575331 | Nucleic acid binding protein 1b. (203 aa) |
