Your Input: | |
| | rpain | Uncharacterized protein. (226 aa) |
| | LOC113573002 | WD_REPEATS_REGION domain-containing protein. (682 aa) |
| | rnf168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (471 aa) |
| | mcm2 | DNA helicase; Belongs to the MCM family. (908 aa) |
| | LOC113588689 | Nucleic acid binding protein 2. (156 aa) |
| | ung | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (295 aa) |
| | apex2 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (567 aa) |
| | zfyve26 | Zinc finger, FYVE domain containing 26. (2547 aa) |
| | fan1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1005 aa) |
| | top2b | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1600 aa) |
| | mcm6 | DNA helicase; Belongs to the MCM family. (830 aa) |
| | LOC113582267 | Breast cancer 2, early onset. (2391 aa) |
| | LOC113578445 | RAD21 cohesin complex component b. (620 aa) |
| | ENSEEEP00000019307 | Uncharacterized protein. (258 aa) |
| | nipbl | Nipped-B protein. (2652 aa) |
| | exo1 | Exonuclease 1. (771 aa) |
| | mcm8 | MCM domain-containing protein; Belongs to the MCM family. (844 aa) |
| | mms22l | Uncharacterized protein. (1240 aa) |
| | MCMDC2 | Minichromosome maintenance domain containing 2. (372 aa) |
| | ercc4 | ERCC4 domain-containing protein. (899 aa) |
| | trip13 | Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (423 aa) |
| | cdc45 | Uncharacterized protein. (574 aa) |
| | dmc1 | DNA meiotic recombinase 1. (324 aa) |
| | swi5 | SWI5 homologous recombination repair protein. (140 aa) |
| | spidr | DUF4503 domain-containing protein. (573 aa) |
| | mcm4 | DNA helicase; Belongs to the MCM family. (848 aa) |
| | cdc7 | Protein kinase domain-containing protein. (555 aa) |
| | xrcc6 | Uncharacterized protein. (627 aa) |
| | smc5 | Structural maintenance of chromosomes 5. (1083 aa) |
| | rpa3 | Uncharacterized protein. (122 aa) |
| | hsf2bp | Heat shock transcription factor 2 binding protein. (329 aa) |
| | lig4 | DNA ligase. (909 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (667 aa) |
| | pif1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (636 aa) |
| | ENSEEEP00000025109 | Meiosis-specific, MEI4 homolog (S. cerevisiae). (303 aa) |
| | gins4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (224 aa) |
| | aicda | CMP/dCMP-type deaminase domain-containing protein. (219 aa) |
| | msh5 | MutS homolog 5. (760 aa) |
| | fancb | Uncharacterized protein. (822 aa) |
| | ino80 | Uncharacterized protein. (1128 aa) |
| | poll | Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family. (585 aa) |
| | msh3 | MutS homolog 3 (E. coli). (1052 aa) |
| | LOC113575016 | Ankyrin repeat domain 31. (219 aa) |
| | rnf8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (484 aa) |
| | ruvbl2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (491 aa) |
| | LOC113589524 | RECA_2 domain-containing protein. (121 aa) |
| | hdgfl2 | PWWP domain-containing protein. (648 aa) |
| | ENSEEEP00000029058 | CTNNB1_binding domain-containing protein. (167 aa) |
| | recql | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (826 aa) |
| | ENSEEEP00000029755 | Histone H2A; Belongs to the histone H2A family. (140 aa) |
| | LOC113570214 | Histone H2A; Belongs to the histone H2A family. (140 aa) |
| | actr5 | Uncharacterized protein; Belongs to the actin family. (646 aa) |
| | ENSEEEP00000029998 | Uncharacterized protein. (608 aa) |
| | xrcc1 | X-ray repair complementing defective repair in Chinese hamster cells 1. (539 aa) |
| | psmd14 | MPN domain-containing protein. (330 aa) |
| | helq | Uncharacterized protein. (1026 aa) |
| | LOC113576847 | RING-type domain-containing protein. (995 aa) |
| | nsmce4a | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (358 aa) |
| | tcf7 | Transcription factor 7. (429 aa) |
| | sem1 | Uncharacterized protein. (70 aa) |
| | rad52 | RAD52 homolog, DNA repair protein. (287 aa) |
| | msh6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1371 aa) |
| | ENSEEEP00000046229 | Uncharacterized protein. (283 aa) |
| | xrcc4 | Uncharacterized protein. (343 aa) |
| | hfm1 | HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae). (1040 aa) |
| | LOC113582703 | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1597 aa) |
| | tonsl | Tonsoku-like, DNA repair protein. (1431 aa) |
| | xrcc5 | Ku domain-containing protein. (740 aa) |
| | ENSEEEP00000043756 | XPGI domain-containing protein. (341 aa) |
| | exosc3 | KH_dom_type_1 domain-containing protein. (245 aa) |
| | lig1 | DNA ligase. (941 aa) |
| | ENSEEEP00000032310 | ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (3024 aa) |
| | tprkb | Uncharacterized protein; Belongs to the CGI121/TPRKB family. (174 aa) |
| | mcm3 | DNA helicase; Belongs to the MCM family. (815 aa) |
| | hus1 | Checkpoint protein; Belongs to the HUS1 family. (283 aa) |
| | ino80c | YL1_C domain-containing protein. (211 aa) |
| | mus81 | MUS81 structure-specific endonuclease subunit. (615 aa) |
| | mcm7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (732 aa) |
| | Ccnb1ip1 | Cyclin B1 interacting protein 1. (111 aa) |
| | LOC113574037 | Uncharacterized protein. (877 aa) |
| | ercc1 | Uncharacterized protein. (346 aa) |
| | ppp4c | Serine/threonine-protein phosphatase. (307 aa) |
| | XRCC2 | RECA_2 domain-containing protein. (302 aa) |
| | LOC113577337 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (263 aa) |
| | LOC113575219 | Uncharacterized protein. (287 aa) |
| | rag2 | RAG2_PHD domain-containing protein. (531 aa) |
| | rag1 | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1085 aa) |
| | fbh1 | F-box domain-containing protein. (1043 aa) |
| | LOC113567594 | Si:dkey-119f1.1. (1009 aa) |
| | LOC113584242 | WD_REPEATS_REGION domain-containing protein. (719 aa) |
| | ENSEEEP00000037636 | Helicase C-terminal domain-containing protein. (432 aa) |
| | ENSEEEP00000037634 | ERCC4 domain-containing protein. (1166 aa) |
| | Recql5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (970 aa) |
| | cenpx | Uncharacterized protein. (81 aa) |
| | ENSEEEP00000036356 | Histone H2A; Belongs to the histone H2A family. (158 aa) |
| | gins2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (182 aa) |
| | ankle1 | Zgc:85936. (862 aa) |
| | msh2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (939 aa) |
| | LOC113567536 | Uncharacterized protein. (1086 aa) |
| | blm | BLM RecQ like helicase. (1281 aa) |
| | rbbp8 | SAE2 domain-containing protein. (131 aa) |
| | ino80b | PAPA-1 domain-containing protein. (333 aa) |
| | rec114 | REC114 meiotic recombination protein. (189 aa) |
| | rad51ap1 | RAD51_interact domain-containing protein. (230 aa) |
| | LOC113591806 | Nipped-B protein. (2259 aa) |
| | nsmce2 | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (257 aa) |
| | rec8 | REC8 meiotic recombination protein b. (439 aa) |
| | Aunip | Uncharacterized protein. (237 aa) |
| | ENSEEEP00000018543 | Methionine sulfoxide reductase B1b. (259 aa) |
| | Lef1 | Lymphoid enhancer-binding factor 1. (212 aa) |
| | Rev3l | DNA_pol_B domain-containing protein. (304 aa) |
| | ruvbl1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa) |
| | ENSEEEP00000051173 | TCF3 (E2A) fusion partner. (165 aa) |
| | rhno1 | Uncharacterized protein. (308 aa) |
| | eme1 | Essential meiotic structure-specific endonuclease 1. (550 aa) |
| | LOC113583054 | TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (264 aa) |
| | fancd2 | FA complementation group D2. (1261 aa) |
| | prkdc | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4099 aa) |
| | rad51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | batf | BZIP domain-containing protein. (123 aa) |
| | ENSEEEP00000016716 | Helicase ATP-binding domain-containing protein. (320 aa) |
| | xrcc3 | RECA_2 domain-containing protein. (355 aa) |
| | mcm5 | DNA helicase; Belongs to the MCM family. (738 aa) |
| | mlh1 | DNA_mis_repair domain-containing protein. (724 aa) |
| | mnd1 | Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (205 aa) |
| | mcm9 | MCM domain-containing protein; Belongs to the MCM family. (1143 aa) |
| | DCAF1 | LisH domain-containing protein. (1540 aa) |
| | spo11 | SPO11 meiotic protein covalently bound to DSB. (368 aa) |
| | rad50 | RAD50 homolog, double strand break repair protein. (1181 aa) |
| | ap5z1 | Adaptor related protein complex 5 subunit zeta 1. (668 aa) |
| | zswim7 | SWIM-type domain-containing protein. (145 aa) |
| | msh4 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (894 aa) |
| | C1orf146 | Chromosome 1 open reading frame 146. (169 aa) |
| | ENSEEEP00000011546 | Uncharacterized protein. (890 aa) |
| | recql4 | RecQ helicase-like 4. (817 aa) |
| | ENSEEEP00000050839 | Metallophos domain-containing protein. (106 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1009 aa) |
| | psmc3ip | Uncharacterized protein. (237 aa) |
| | nbn | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (816 aa) |
| | kiaa1841 | Si:ch211-189k9.2. (716 aa) |
| | rtel1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1163 aa) |
| | rad51d | RECA_2 domain-containing protein. (338 aa) |
| | lig3 | DNA ligase. (1009 aa) |
| | supv3l1 | Uncharacterized protein. (767 aa) |
| | dclre1c | DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae). (683 aa) |
| | pagr1 | Uncharacterized protein. (270 aa) |
| | pgbd5 | DDE_Tnp_1_7 domain-containing protein. (515 aa) |
| | ENSEEEP00000007003 | AAA_23 domain-containing protein. (53 aa) |
| | hdac10 | Hist_deacetyl domain-containing protein. (673 aa) |
| | hrob | Si:dkey-260c8.8. (375 aa) |
| | ENSEEEP00000006834 | Uncharacterized protein. (110 aa) |
| | LOC113578819 | Uncharacterized protein. (638 aa) |
| | LOC113569058 | AAA_23 domain-containing protein. (469 aa) |
| | LOC113568938 | Histone H2A; Belongs to the histone H2A family. (115 aa) |
| | syce3 | Uncharacterized protein. (96 aa) |
| | ENSEEEP00000005036 | Uncharacterized protein. (813 aa) |
| | ENSEEEP00000004640 | Rad21_Rec8_N domain-containing protein. (138 aa) |
| | ENSEEEP00000004636 | Rad21_Rec8 domain-containing protein. (66 aa) |
| | ino80e | Uncharacterized protein. (386 aa) |
| | LOC113568250 | RAD51 paralog C. (260 aa) |
| | rmi1 | DUF1767 domain-containing protein. (587 aa) |
| | LOC113575351 | Uncharacterized protein. (215 aa) |
| | actr8 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (636 aa) |
| | LOC113584344 | DNA helicase; Belongs to the MCM family. (820 aa) |
| | exd2 | Exonuclease 3'-5' domain containing 2. (616 aa) |
| | samhd1 | Uncharacterized protein. (623 aa) |
| | brip1 | Helicase ATP-binding domain-containing protein. (1220 aa) |
| | rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (624 aa) |
| | nsmce1 | zf-RING-like domain-containing protein. (274 aa) |
| | LOC113585995 | DNA helicase; Belongs to the MCM family. (801 aa) |
| | rmi2 | Uncharacterized protein. (147 aa) |
| | LOC113569503 | Uncharacterized protein. (225 aa) |
| | LOC113575331 | Nucleic acid binding protein 1b. (203 aa) |
| | ap5s1 | Uncharacterized protein. (200 aa) |
