(23 nodes) Negative regulation of macroautophagy network (Electrophorus electricus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	lrrk2	Leucine-rich repeat kinase 2. (2512 aa)
	ENSEEEP00000003759	Uncharacterized protein. (76 aa)
	pink1	Protein kinase domain-containing protein. (579 aa)
	scfd1	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (629 aa)
	Tsc1	Uncharacterized protein. (383 aa)
	LOC113582109	ApaG domain-containing protein. (380 aa)
	ENSEEEP00000018338	Fasciculation and elongation protein zeta 1 (zygin I). (402 aa)
	Fez1	Fasciculation and elongation protein zeta 1 (zygin I). (164 aa)
	tmem39a	Uncharacterized protein. (567 aa)
	phf23	PHD domain-containing protein. (320 aa)
	smg1	SMG1 phosphatidylinositol 3-kinase-related kinase; Belongs to the PI3/PI4-kinase family. (3631 aa)
	nrbp2	Nuclear receptor binding protein 2a. (399 aa)
	LOC113570273	PHD domain-containing protein. (305 aa)
	tsc2	TSC complex subunit 2. (1801 aa)
	LOC113580905	Smith-Magenis syndrome chromosome region, candidate 8b. (797 aa)
	ENSEEEP00000042802	Uncharacterized protein. (380 aa)
	clec16a	C-type lectin domain containing 16A. (1034 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2557 aa)
	tmem39b	Uncharacterized protein. (486 aa)
	LOC113584826	Leucine zipper, putative tumor suppressor 1. (578 aa)
	LOC113582955	Uncharacterized protein. (365 aa)
	LOC113583120	Si:dkey-288i20.2. (356 aa)
	LOC113569737	Polymerase (DNA-directed), delta interacting protein 2. (390 aa)

Your Current Organism:

Electrophorus electricus

NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSEEEP00000042802	mtor	ENSEEEP00000042802	ENSEEEP00000045364	Uncharacterized protein.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.891
ENSEEEP00000042802	pink1	ENSEEEP00000042802	ENSEEEP00000003966	Uncharacterized protein.	Protein kinase domain-containing protein.	0.507
ENSEEEP00000042802	smg1	ENSEEEP00000042802	ENSEEEP00000028880	Uncharacterized protein.	SMG1 phosphatidylinositol 3-kinase-related kinase; Belongs to the PI3/PI4-kinase family.	0.657
ENSEEEP00000042802	tsc2	ENSEEEP00000042802	ENSEEEP00000038113	Uncharacterized protein.	TSC complex subunit 2.	0.972
Tsc1	mtor	ENSEEEP00000007351	ENSEEEP00000045364	Uncharacterized protein.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.891
Tsc1	pink1	ENSEEEP00000007351	ENSEEEP00000003966	Uncharacterized protein.	Protein kinase domain-containing protein.	0.507
Tsc1	smg1	ENSEEEP00000007351	ENSEEEP00000028880	Uncharacterized protein.	SMG1 phosphatidylinositol 3-kinase-related kinase; Belongs to the PI3/PI4-kinase family.	0.657
Tsc1	tsc2	ENSEEEP00000007351	ENSEEEP00000038113	Uncharacterized protein.	TSC complex subunit 2.	0.972
clec16a	tmem39a	ENSEEEP00000045318	ENSEEEP00000024593	C-type lectin domain containing 16A.	Uncharacterized protein.	0.442
lrrk2	pink1	ENSEEEP00000003360	ENSEEEP00000003966	Leucine-rich repeat kinase 2.	Protein kinase domain-containing protein.	0.548
mtor	ENSEEEP00000042802	ENSEEEP00000045364	ENSEEEP00000042802	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.891
mtor	Tsc1	ENSEEEP00000045364	ENSEEEP00000007351	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.891
mtor	tsc2	ENSEEEP00000045364	ENSEEEP00000038113	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	TSC complex subunit 2.	0.933
pink1	ENSEEEP00000042802	ENSEEEP00000003966	ENSEEEP00000042802	Protein kinase domain-containing protein.	Uncharacterized protein.	0.507
pink1	Tsc1	ENSEEEP00000003966	ENSEEEP00000007351	Protein kinase domain-containing protein.	Uncharacterized protein.	0.507
pink1	lrrk2	ENSEEEP00000003966	ENSEEEP00000003360	Protein kinase domain-containing protein.	Leucine-rich repeat kinase 2.	0.548
smg1	ENSEEEP00000042802	ENSEEEP00000028880	ENSEEEP00000042802	SMG1 phosphatidylinositol 3-kinase-related kinase; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.657
smg1	Tsc1	ENSEEEP00000028880	ENSEEEP00000007351	SMG1 phosphatidylinositol 3-kinase-related kinase; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.657
smg1	tsc2	ENSEEEP00000028880	ENSEEEP00000038113	SMG1 phosphatidylinositol 3-kinase-related kinase; Belongs to the PI3/PI4-kinase family.	TSC complex subunit 2.	0.781
tmem39a	clec16a	ENSEEEP00000024593	ENSEEEP00000045318	Uncharacterized protein.	C-type lectin domain containing 16A.	0.442