(48 nodes) Regulation of mitotic metaphase/anaphase transition network (Electrophorus electricus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	ENSEEEP00000025773	Uncharacterized protein. (288 aa)
	LOC113585134	Translocated promoter region b, nuclear basket protein. (2308 aa)
	cul3	Cullin 3; Belongs to the cullin family. (734 aa)
	cdc27	TPR_REGION domain-containing protein. (834 aa)
	LOC113592334	CULLIN_2 domain-containing protein; Belongs to the cullin family. (560 aa)
	spdl1	Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex; Belongs to the Spindly family. (573 aa)
	ENSEEEP00000032310	ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (3024 aa)
	cdc26	Uncharacterized protein. (87 aa)
	nsmce2	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (257 aa)
	cdc6	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (543 aa)
	LOC113587944	Translocated promoter region a, nuclear basket protein. (2292 aa)
	cdt1	Chromatin licensing and DNA replication factor 1. (679 aa)
	bub3	BUB3 mitotic checkpoint protein. (325 aa)
	anapc4	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (809 aa)
	ENSEEEP00000043756	XPGI domain-containing protein. (341 aa)
	anapc7	Uncharacterized protein. (594 aa)
	bub1b	BUB1 N-terminal domain-containing protein. (421 aa)
	LOC113583751	Uncharacterized protein. (204 aa)
	riok2	RIO domain-containing protein. (516 aa)
	cdc16	TPR_REGION domain-containing protein. (613 aa)
	ttk	Ttk protein kinase. (848 aa)
	kntc1	Kinetochore associated 1. (2160 aa)
	bcl7a	Uncharacterized protein. (202 aa)
	bub1	BUB1 mitotic checkpoint serine/threonine kinase. (803 aa)
	haspin	Si:dkeyp-26a9.2. (612 aa)
	klhl22	Kelch-like family member 22. (585 aa)
	anapc5	ANAPC5 domain-containing protein. (762 aa)
	cdc23	TPR_REGION domain-containing protein. (596 aa)
	mad2l1bp	Uncharacterized protein. (393 aa)
	ENSEEEP00000007029	Cnn_1N domain-containing protein. (178 aa)
	zwilch	Zwilch kinetochore protein. (582 aa)
	anapc15	Uncharacterized protein. (121 aa)
	mad2l1	HORMA domain-containing protein. (202 aa)
	rb1	Retinoblastoma 1. (901 aa)
	LOC113574368	Zinc finger protein 207, a. (403 aa)
	zw10	Zw10 kinetochore protein. (763 aa)
	LOC113567833	CULLIN_2 domain-containing protein; Belongs to the cullin family. (232 aa)
	anapc11	RING-type domain-containing protein. (88 aa)
	LOC113578832	Uncharacterized protein. (426 aa)
	ENSEEEP00000000831	Uncharacterized protein. (39 aa)
	LOC113592194	BCL tumor suppressor 7Ba. (350 aa)
	ube2c	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (187 aa)
	ndc80	DUF5595 domain-containing protein. (637 aa)
	xrcc3	RECA_2 domain-containing protein. (355 aa)
	LOC113585558	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (326 aa)
	ENSEEEP00000018609	Uncharacterized protein. (467 aa)
	lcmt1	Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (327 aa)
	mad1l1	Uncharacterized protein. (715 aa)

Your Current Organism:

Electrophorus electricus

NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSEEEP00000000831	ENSEEEP00000018609	ENSEEEP00000000831	ENSEEEP00000018609	Uncharacterized protein.	Uncharacterized protein.	0.853
ENSEEEP00000000831	LOC113585558	ENSEEEP00000000831	ENSEEEP00000017479	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.581
ENSEEEP00000000831	anapc11	ENSEEEP00000000831	ENSEEEP00000012017	Uncharacterized protein.	RING-type domain-containing protein.	0.873
ENSEEEP00000000831	anapc15	ENSEEEP00000000831	ENSEEEP00000008057	Uncharacterized protein.	Uncharacterized protein.	0.930
ENSEEEP00000000831	anapc4	ENSEEEP00000000831	ENSEEEP00000043742	Uncharacterized protein.	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.	0.972
ENSEEEP00000000831	anapc5	ENSEEEP00000000831	ENSEEEP00000001427	Uncharacterized protein.	ANAPC5 domain-containing protein.	0.972
ENSEEEP00000000831	anapc7	ENSEEEP00000000831	ENSEEEP00000044464	Uncharacterized protein.	Uncharacterized protein.	0.959
ENSEEEP00000000831	bub1	ENSEEEP00000000831	ENSEEEP00000051405	Uncharacterized protein.	BUB1 mitotic checkpoint serine/threonine kinase.	0.853
ENSEEEP00000000831	bub1b	ENSEEEP00000000831	ENSEEEP00000045400	Uncharacterized protein.	BUB1 N-terminal domain-containing protein.	0.853
ENSEEEP00000000831	bub3	ENSEEEP00000000831	ENSEEEP00000043150	Uncharacterized protein.	BUB3 mitotic checkpoint protein.	0.968
ENSEEEP00000000831	cdc16	ENSEEEP00000000831	ENSEEEP00000047246	Uncharacterized protein.	TPR_REGION domain-containing protein.	0.972
ENSEEEP00000000831	cdc23	ENSEEEP00000000831	ENSEEEP00000001791	Uncharacterized protein.	TPR_REGION domain-containing protein.	0.931
ENSEEEP00000000831	cdc26	ENSEEEP00000000831	ENSEEEP00000033414	Uncharacterized protein.	Uncharacterized protein.	0.963
ENSEEEP00000000831	cdc6	ENSEEEP00000000831	ENSEEEP00000036001	Uncharacterized protein.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.765
ENSEEEP00000000831	cdt1	ENSEEEP00000000831	ENSEEEP00000041412	Uncharacterized protein.	Chromatin licensing and DNA replication factor 1.	0.494
ENSEEEP00000000831	mad2l1	ENSEEEP00000000831	ENSEEEP00000008203	Uncharacterized protein.	HORMA domain-containing protein.	0.961
ENSEEEP00000000831	rb1	ENSEEEP00000000831	ENSEEEP00000008413	Uncharacterized protein.	Retinoblastoma 1.	0.524
ENSEEEP00000000831	ttk	ENSEEEP00000000831	ENSEEEP00000048679	Uncharacterized protein.	Ttk protein kinase.	0.519
ENSEEEP00000000831	ube2c	ENSEEEP00000000831	ENSEEEP00000014755	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.912
ENSEEEP00000018609	ENSEEEP00000000831	ENSEEEP00000018609	ENSEEEP00000000831	Uncharacterized protein.	Uncharacterized protein.	0.853