(44 nodes) Embryonic limb morphogenesis network (Electrophorus electricus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ift140	Intraflagellar transport 140 homolog (Chlamydomonas). (1456 aa)
	sall4	Uncharacterized protein. (1090 aa)
	LOC113585953	T-box 2a. (670 aa)
	med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1806 aa)
	GREM1	Gremlin 1, DAN family BMP antagonist. (166 aa)
	Bcl2l11	Bclx_interact domain-containing protein. (195 aa)
	mks1	Meckel syndrome, type 1. (488 aa)
	fbxw4	Uncharacterized protein. (415 aa)
	fras1	Fraser extracellular matrix complex subunit 1. (3972 aa)
	ENSEEEP00000001488	Mothers against decapentaplegic homolog. (440 aa)
	tbx4	T-box 4. (536 aa)
	dkk1	Dickkopf_N domain-containing protein. (232 aa)
	LOC113591070	Uncharacterized protein. (3142 aa)
	LOC113585617	Dickkopf WNT signaling pathway inhibitor 1a. (237 aa)
	LOC113589007	Uncharacterized protein. (264 aa)
	bax	BCL2 associated X, apoptosis regulator a. (192 aa)
	LOC113581577	Uncharacterized protein. (355 aa)
	rpgrip1l	RPGRIP1-like. (1241 aa)
	ENSEEEP00000009645	Pkinase_Tyr domain-containing protein. (238 aa)
	sp9	Uncharacterized protein. (439 aa)
	ENSEEEP00000010058	Uncharacterized protein. (117 aa)
	Tbx3	Uncharacterized protein. (133 aa)
	ENSEEEP00000010654	Uncharacterized protein. (114 aa)
	LOC113580065	Protein kinase domain-containing protein. (462 aa)
	LOC113567946	Mothers against decapentaplegic homolog. (524 aa)
	Lef1	Lymphoid enhancer-binding factor 1. (212 aa)
	LOC113582281	Fras1 related extracellular matrix protein 2b. (3138 aa)
	smad4	Mothers against decapentaplegic homolog. (545 aa)
	ift52	ABC_transp_aux domain-containing protein. (439 aa)
	ENSEEEP00000023535	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (76 aa)
	LOC113571212	Uncharacterized protein. (454 aa)
	ENSEEEP00000029058	CTNNB1_binding domain-containing protein. (167 aa)
	LOC113571196	Mothers against decapentaplegic homolog. (572 aa)
	wdr19	WD_REPEATS_REGION domain-containing protein. (1347 aa)
	fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (191 aa)
	ENSEEEP00000039247	Uncharacterized protein. (253 aa)
	LOC113588363	Homeobox protein engrailed-like. (275 aa)
	en1	Homeobox protein engrailed-like. (277 aa)
	ALX3	ALX homeobox 3. (178 aa)
	msx1	Homeobox domain-containing protein. (282 aa)
	LOC113570408	Homeobox domain-containing protein. (337 aa)
	LOC113588416	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (204 aa)
	LOC113588122	T-box 3b. (611 aa)
	sfrp2	Uncharacterized protein. (291 aa)

Your Current Organism:

Electrophorus electricus

NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bcl2l11	bax	ENSEEEP00000046201	ENSEEEP00000006826	Bclx_interact domain-containing protein.	BCL2 associated X, apoptosis regulator a.	0.905
ENSEEEP00000009645	LOC113580065	ENSEEEP00000009645	ENSEEEP00000012335	Pkinase_Tyr domain-containing protein.	Protein kinase domain-containing protein.	0.901
ENSEEEP00000010058	mks1	ENSEEEP00000010058	ENSEEEP00000044664	Uncharacterized protein.	Meckel syndrome, type 1.	0.574
ENSEEEP00000010654	Tbx3	ENSEEEP00000010654	ENSEEEP00000010653	Uncharacterized protein.	Uncharacterized protein.	0.535
ENSEEEP00000029058	Lef1	ENSEEEP00000029058	ENSEEEP00000018408	CTNNB1_binding domain-containing protein.	Lymphoid enhancer-binding factor 1.	0.452
ENSEEEP00000029058	msx1	ENSEEEP00000029058	ENSEEEP00000042720	CTNNB1_binding domain-containing protein.	Homeobox domain-containing protein.	0.422
LOC113571196	Lef1	ENSEEEP00000032266	ENSEEEP00000018408	Mothers against decapentaplegic homolog.	Lymphoid enhancer-binding factor 1.	0.937
LOC113571196	smad4	ENSEEEP00000032266	ENSEEEP00000020048	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.901
LOC113580065	ENSEEEP00000009645	ENSEEEP00000012335	ENSEEEP00000009645	Protein kinase domain-containing protein.	Pkinase_Tyr domain-containing protein.	0.901
LOC113582281	fras1	ENSEEEP00000018671	ENSEEEP00000001471	Fras1 related extracellular matrix protein 2b.	Fraser extracellular matrix complex subunit 1.	0.491
LOC113591070	fras1	ENSEEEP00000005039	ENSEEEP00000001471	Uncharacterized protein.	Fraser extracellular matrix complex subunit 1.	0.491
Lef1	ENSEEEP00000029058	ENSEEEP00000018408	ENSEEEP00000029058	Lymphoid enhancer-binding factor 1.	CTNNB1_binding domain-containing protein.	0.452
Lef1	LOC113571196	ENSEEEP00000018408	ENSEEEP00000032266	Lymphoid enhancer-binding factor 1.	Mothers against decapentaplegic homolog.	0.937
Lef1	msx1	ENSEEEP00000018408	ENSEEEP00000042720	Lymphoid enhancer-binding factor 1.	Homeobox domain-containing protein.	0.422
Lef1	smad4	ENSEEEP00000018408	ENSEEEP00000020048	Lymphoid enhancer-binding factor 1.	Mothers against decapentaplegic homolog.	0.937
Tbx3	ENSEEEP00000010654	ENSEEEP00000010653	ENSEEEP00000010654	Uncharacterized protein.	Uncharacterized protein.	0.535
bax	Bcl2l11	ENSEEEP00000006826	ENSEEEP00000046201	BCL2 associated X, apoptosis regulator a.	Bclx_interact domain-containing protein.	0.905
fras1	LOC113582281	ENSEEEP00000001471	ENSEEEP00000018671	Fraser extracellular matrix complex subunit 1.	Fras1 related extracellular matrix protein 2b.	0.491
fras1	LOC113591070	ENSEEEP00000001471	ENSEEEP00000005039	Fraser extracellular matrix complex subunit 1.	Uncharacterized protein.	0.491
ift140	ift52	ENSEEEP00000051039	ENSEEEP00000022817	Intraflagellar transport 140 homolog (Chlamydomonas).	ABC_transp_aux domain-containing protein.	0.849