54 items (Electrophorus electricus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	samhd1	Uncharacterized protein. (623 aa)
	ddb1	CPSF_A domain-containing protein. (1147 aa)
	smchd1	Structural maintenance of chromosomes flexible hinge domain containing 1. (1984 aa)
	sirt6	Deacetylase sirtuin-type domain-containing protein. (396 aa)
	LOC113569058	AAA_23 domain-containing protein. (469 aa)
	sirt7	Deacetylase sirtuin-type domain-containing protein. (405 aa)
	ENSEEEP00000007003	AAA_23 domain-containing protein. (53 aa)
	arpc3	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
	LOC113589954	Uncharacterized protein. (234 aa)
	rif1	Replication timing regulatory factor 1. (2379 aa)
	shld2	FAM35_C domain-containing protein. (814 aa)
	ufl1	Uncharacterized protein. (784 aa)
	rad50	RAD50 homolog, double strand break repair protein. (1181 aa)
	LOC113585138	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (299 aa)
	LOC113591245	Uncharacterized protein. (743 aa)
	rad51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
	LOC113576019	Uncharacterized protein. (197 aa)
	timeless	Timeless circadian clock. (1201 aa)
	polh	Polymerase (DNA directed), eta. (700 aa)
	ENSEEEP00000018711	Zgc:101664. (195 aa)
	paxx	Uncharacterized protein. (192 aa)
	WDR70	WD_REPEATS_REGION domain-containing protein. (638 aa)
	LOC113578936	Uncharacterized protein. (296 aa)
	rpa3	Uncharacterized protein. (122 aa)
	mre11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (667 aa)
	poll	Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family. (585 aa)
	rnf8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (484 aa)
	parp1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1012 aa)
	slf1	ANK_REP_REGION domain-containing protein. (905 aa)
	LOC113572712	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (410 aa)
	wrap53	WD repeat containing, antisense to TP53. (519 aa)
	LOC113585161	Uncharacterized protein. (394 aa)
	rec114	REC114 meiotic recombination protein. (189 aa)
	rbbp8	SAE2 domain-containing protein. (131 aa)
	ENSEEEP00000035317	Zgc:165656. (272 aa)
	actr2	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (396 aa)
	LOC113575160	Uncharacterized protein. (757 aa)
	helb	Helicase (DNA) B. (1009 aa)
	ENSEEEP00000039677	ARP3 actin related protein 3 homolog B; Belongs to the actin family. (365 aa)
	actr3	Uncharacterized protein; Belongs to the actin family. (441 aa)
	hus1	Checkpoint protein; Belongs to the HUS1 family. (283 aa)
	tonsl	Tonsoku-like, DNA repair protein. (1431 aa)
	LOC113592019	Zgc:136908; Belongs to the AAA ATPase family. (806 aa)
	xrcc4	Uncharacterized protein. (343 aa)
	vcp	Uncharacterized protein; Belongs to the AAA ATPase family. (806 aa)
	ARPC2	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (365 aa)
	Rnf169	RING-type domain-containing protein. (106 aa)
	LOC113588689	Nucleic acid binding protein 2. (156 aa)
	pnkp	FHA_2 domain-containing protein. (595 aa)
	rnf168	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (471 aa)
	prpf19	Pre-mRNA processing factor 19. (499 aa)
	ENSEEEP00000050839	Metallophos domain-containing protein. (106 aa)
	parp3	Poly [ADP-ribose] polymerase. (527 aa)
	rad18	RAD18 E3 ubiquitin protein ligase. (459 aa)

Your Current Organism:

Electrophorus electricus

NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARPC2	ENSEEEP00000039677	ENSEEEP00000049442	ENSEEEP00000039677	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	ARP3 actin related protein 3 homolog B; Belongs to the actin family.	0.968
ARPC2	LOC113572712	ENSEEEP00000049442	ENSEEEP00000031669	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.939
ARPC2	LOC113576019	ENSEEEP00000049442	ENSEEEP00000018250	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	Uncharacterized protein.	0.971
ARPC2	LOC113585138	ENSEEEP00000049442	ENSEEEP00000015080	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.900
ARPC2	LOC113585161	ENSEEEP00000049442	ENSEEEP00000033108	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	Uncharacterized protein.	0.908
ARPC2	LOC113589954	ENSEEEP00000049442	ENSEEEP00000007885	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	Uncharacterized protein.	0.995
ARPC2	actr2	ENSEEEP00000049442	ENSEEEP00000035767	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.939
ARPC2	actr3	ENSEEEP00000049442	ENSEEEP00000040936	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	Uncharacterized protein; Belongs to the actin family.	0.968
ARPC2	arpc3	ENSEEEP00000049442	ENSEEEP00000007177	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.998
ENSEEEP00000007003	ENSEEEP00000050839	ENSEEEP00000007003	ENSEEEP00000050839	AAA_23 domain-containing protein.	Metallophos domain-containing protein.	0.954
ENSEEEP00000007003	Rnf169	ENSEEEP00000007003	ENSEEEP00000049936	AAA_23 domain-containing protein.	RING-type domain-containing protein.	0.479
ENSEEEP00000007003	hus1	ENSEEEP00000007003	ENSEEEP00000043450	AAA_23 domain-containing protein.	Checkpoint protein; Belongs to the HUS1 family.	0.504
ENSEEEP00000007003	mre11	ENSEEEP00000007003	ENSEEEP00000024860	AAA_23 domain-containing protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.954
ENSEEEP00000007003	parp1	ENSEEEP00000007003	ENSEEEP00000030073	AAA_23 domain-containing protein.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.487
ENSEEEP00000007003	parp3	ENSEEEP00000007003	ENSEEEP00000052156	AAA_23 domain-containing protein.	Poly [ADP-ribose] polymerase.	0.423
ENSEEEP00000007003	polh	ENSEEEP00000007003	ENSEEEP00000018380	AAA_23 domain-containing protein.	Polymerase (DNA directed), eta.	0.582
ENSEEEP00000007003	rad18	ENSEEEP00000007003	ENSEEEP00000052166	AAA_23 domain-containing protein.	RAD18 E3 ubiquitin protein ligase.	0.446
ENSEEEP00000007003	rad51	ENSEEEP00000007003	ENSEEEP00000017370	AAA_23 domain-containing protein.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.825
ENSEEEP00000007003	rbbp8	ENSEEEP00000007003	ENSEEEP00000034871	AAA_23 domain-containing protein.	SAE2 domain-containing protein.	0.837
ENSEEEP00000007003	rif1	ENSEEEP00000007003	ENSEEEP00000008598	AAA_23 domain-containing protein.	Replication timing regulatory factor 1.	0.465