(13 nodes) Atrioventricular canal development network (Electrophorus electricus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSEEEP00000001488	Mothers against decapentaplegic homolog. (440 aa)
	tbx2	TBX domain-containing protein. (690 aa)
	LOC113589901	Fork-head domain-containing protein. (513 aa)
	Tbx3	Uncharacterized protein. (133 aa)
	ENSEEEP00000010654	Uncharacterized protein. (114 aa)
	tbx5	Uncharacterized protein. (521 aa)
	LOC113567946	Mothers against decapentaplegic homolog. (524 aa)
	smad4	Mothers against decapentaplegic homolog. (545 aa)
	med10	Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (134 aa)
	LOC113571196	Mothers against decapentaplegic homolog. (572 aa)
	LOC113588122	T-box 3b. (611 aa)
	LOC113585953	T-box 2a. (670 aa)
	ENSEEEP00000052101	POU domain protein. (321 aa)

Your Current Organism:

Electrophorus electricus

NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSEEEP00000010654	Tbx3	ENSEEEP00000010654	ENSEEEP00000010653	Uncharacterized protein.	Uncharacterized protein.	0.535
LOC113571196	smad4	ENSEEEP00000032266	ENSEEEP00000020048	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.901
LOC113589901	tbx2	ENSEEEP00000006620	ENSEEEP00000001779	Fork-head domain-containing protein.	TBX domain-containing protein.	0.427
Tbx3	ENSEEEP00000010654	ENSEEEP00000010653	ENSEEEP00000010654	Uncharacterized protein.	Uncharacterized protein.	0.535
smad4	LOC113571196	ENSEEEP00000020048	ENSEEEP00000032266	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.901
tbx2	LOC113589901	ENSEEEP00000001779	ENSEEEP00000006620	TBX domain-containing protein.	Fork-head domain-containing protein.	0.427