node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSEEEP00000007003 | pot1 | ENSEEEP00000007003 | ENSEEEP00000018754 | AAA_23 domain-containing protein. | Protection of telomeres 1 homolog. | 0.447 |
ENSEEEP00000007003 | rpa1 | ENSEEEP00000007003 | ENSEEEP00000001444 | AAA_23 domain-containing protein. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.724 |
ENSEEEP00000043857 | pot1 | ENSEEEP00000043857 | ENSEEEP00000018754 | Telomeric repeat binding factor a. | Protection of telomeres 1 homolog. | 0.700 |
LOC113569058 | pot1 | ENSEEEP00000005699 | ENSEEEP00000018754 | AAA_23 domain-containing protein. | Protection of telomeres 1 homolog. | 0.447 |
LOC113569058 | rad50 | ENSEEEP00000005699 | ENSEEEP00000013894 | AAA_23 domain-containing protein. | RAD50 homolog, double strand break repair protein. | 0.958 |
LOC113569058 | rpa1 | ENSEEEP00000005699 | ENSEEEP00000001444 | AAA_23 domain-containing protein. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.724 |
pot1 | ENSEEEP00000007003 | ENSEEEP00000018754 | ENSEEEP00000007003 | Protection of telomeres 1 homolog. | AAA_23 domain-containing protein. | 0.447 |
pot1 | ENSEEEP00000043857 | ENSEEEP00000018754 | ENSEEEP00000043857 | Protection of telomeres 1 homolog. | Telomeric repeat binding factor a. | 0.700 |
pot1 | LOC113569058 | ENSEEEP00000018754 | ENSEEEP00000005699 | Protection of telomeres 1 homolog. | AAA_23 domain-containing protein. | 0.447 |
pot1 | rad50 | ENSEEEP00000018754 | ENSEEEP00000013894 | Protection of telomeres 1 homolog. | RAD50 homolog, double strand break repair protein. | 0.447 |
pot1 | rpa1 | ENSEEEP00000018754 | ENSEEEP00000001444 | Protection of telomeres 1 homolog. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.669 |
pot1 | stn1 | ENSEEEP00000018754 | ENSEEEP00000050079 | Protection of telomeres 1 homolog. | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. | 0.766 |
rad50 | LOC113569058 | ENSEEEP00000013894 | ENSEEEP00000005699 | RAD50 homolog, double strand break repair protein. | AAA_23 domain-containing protein. | 0.958 |
rad50 | pot1 | ENSEEEP00000013894 | ENSEEEP00000018754 | RAD50 homolog, double strand break repair protein. | Protection of telomeres 1 homolog. | 0.447 |
rad50 | rpa1 | ENSEEEP00000013894 | ENSEEEP00000001444 | RAD50 homolog, double strand break repair protein. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.724 |
rpa1 | ENSEEEP00000007003 | ENSEEEP00000001444 | ENSEEEP00000007003 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | AAA_23 domain-containing protein. | 0.724 |
rpa1 | LOC113569058 | ENSEEEP00000001444 | ENSEEEP00000005699 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | AAA_23 domain-containing protein. | 0.724 |
rpa1 | pot1 | ENSEEEP00000001444 | ENSEEEP00000018754 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | Protection of telomeres 1 homolog. | 0.669 |
rpa1 | rad50 | ENSEEEP00000001444 | ENSEEEP00000013894 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | RAD50 homolog, double strand break repair protein. | 0.724 |
rpa1 | stn1 | ENSEEEP00000001444 | ENSEEEP00000050079 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. | 0.915 |