(102 nodes) Regulation of cysteine-type endopeptidase activity involved in apoptotic process network (Electrophorus electricus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC113573990	Uncharacterized protein. (666 aa)
	ints1	DUF3677 domain-containing protein. (2210 aa)
	ENSEEEP00000001199	Uncharacterized protein. (96 aa)
	rnf34	Ring finger protein 34a. (334 aa)
	LOC113578175	Homeobox domain-containing protein. (207 aa)
	mul1	RING-type domain-containing protein. (352 aa)
	ENSEEEP00000003427	Nerve growth factor receptor a (TNFR superfamily, member 16). (407 aa)
	ENSEEEP00000003845	Uncharacterized protein. (151 aa)
	LOC113586001	Uncharacterized protein. (209 aa)
	ENSEEEP00000004636	Rad21_Rec8 domain-containing protein. (66 aa)
	ENSEEEP00000004640	Rad21_Rec8_N domain-containing protein. (138 aa)
	pdcd2	MYND-type domain-containing protein. (356 aa)
	aifm1	Pyr_redox_2 domain-containing protein. (344 aa)
	LOC113578819	Uncharacterized protein. (638 aa)
	diablo	Uncharacterized protein. (231 aa)
	nle1	WD_REPEATS_REGION domain-containing protein. (489 aa)
	ENSEEEP00000006664	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (336 aa)
	bax	BCL2 associated X, apoptosis regulator a. (192 aa)
	LOC113587637	Uncharacterized protein. (267 aa)
	pidd1	P53-induced death domain protein 1. (904 aa)
	arl6ip5	PRA1 family protein. (190 aa)
	LOC113581577	Uncharacterized protein. (355 aa)
	birc2	Baculoviral IAP repeat containing 2. (653 aa)
	casp8ap2	Caspase 8 associated protein 2. (1945 aa)
	LOC113574631	Zgc:171740. (255 aa)
	cdkn2d	ANK_REP_REGION domain-containing protein. (167 aa)
	dele1	Uncharacterized protein. (496 aa)
	prdx3	Thioredoxin domain-containing protein. (247 aa)
	LOC113583936	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (394 aa)
	cradd	Uncharacterized protein. (199 aa)
	LOC113577672	Uncharacterized protein. (142 aa)
	LOC113579372	Non-specific serine/threonine protein kinase. (540 aa)
	LOC113577703	CASP8 and FADD-like apoptosis regulator a; Belongs to the peptidase C14A family. (419 aa)
	LOC113568453	RING-type domain-containing protein. (341 aa)
	cflar	Uncharacterized protein; Belongs to the peptidase C14A family. (478 aa)
	LOC113583403	Tumor necrosis factor a (TNF superfamily, member 2). (241 aa)
	LOC113572347	PRA1 family protein. (190 aa)
	dap	Uncharacterized protein. (105 aa)
	LOC113578445	RAD21 cohesin complex component b. (620 aa)
	oxt	Uncharacterized protein; Belongs to the vasopressin/oxytocin family. (154 aa)
	LOC113581617	Huntingtin interacting protein 1 related b. (1085 aa)
	tnfaip8l1	Uncharacterized protein. (186 aa)
	st18	ST18 C2H2C-type zinc finger transcription factor. (932 aa)
	LOC113588252	Aquaporin 1a (Colton blood group), tandem duplicate 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
	CAAP1	Uncharacterized protein. (310 aa)
	ENSEEEP00000023204	Caspase 8, apoptosis-related cysteine peptidase, like 2; Belongs to the peptidase C14A family. (457 aa)
	LOC113581282	Coagulation factor IIIa. (285 aa)
	LOC113588255	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (270 aa)
	LOC113588254	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (262 aa)
	ENSEEEP00000023817	PYD and CARD domain containing. (205 aa)
	hip1	Huntingtin interacting protein 1. (1087 aa)
	LOC113588302	Uncharacterized protein; Belongs to the peptidase C14A family. (371 aa)
	gas6	Uncharacterized protein. (649 aa)
	LOC113585124	EGF-like domain-containing protein. (616 aa)
	card9	Caspase recruitment domain family, member 9. (536 aa)
	bcl2l12	Uncharacterized protein. (357 aa)
	LOC113586907	Ring finger protein 34b. (389 aa)
	ccn1	Uncharacterized protein. (365 aa)
	gramd4	GRAM domain containing 4a. (583 aa)
	LOC113574504	Uncharacterized protein. (786 aa)
	lamtor5	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (96 aa)
	usp47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1375 aa)
	pdcd5	Uncharacterized protein. (127 aa)
	ctsh	Uncharacterized protein; Belongs to the peptidase C1 family. (347 aa)
	xiap	RING-type domain-containing protein. (461 aa)
	sirt1	Deacetylase sirtuin-type domain-containing protein. (729 aa)
	F3	Uncharacterized protein. (286 aa)
	LOC113587187	Uncharacterized protein; Belongs to the vasopressin/oxytocin family. (154 aa)
	esco2	Establishment of sister chromatid cohesion N-acetyltransferase 2. (619 aa)
	LOC113589104	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (273 aa)
	ENSEEEP00000037234	Neuromast-expressed gpi-anchored lymphocyte antigen 6. (207 aa)
	sox7	Uncharacterized protein. (396 aa)
	LOC113588362	Uncharacterized protein. (215 aa)
	LOC113578802	Uncharacterized protein. (204 aa)
	LOC113577317	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (274 aa)
	LOC113585877	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (278 aa)
	ENSEEEP00000039718	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (175 aa)
	LOC113588667	EGF-like domain-containing protein. (630 aa)
	casp2	Uncharacterized protein; Belongs to the peptidase C14A family. (456 aa)
	ENSEEEP00000042050	Uncharacterized protein. (277 aa)
	LOC113574035	Uncharacterized protein; Belongs to the peptidase C14A family. (369 aa)
	LOC113574024	Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (483 aa)
	LOC113574078	Uveal autoantigen with coiled-coil domains and ankyrin repeats b. (1372 aa)
	map2k5	Mitogen-activated protein kinase kinase 5. (447 aa)
	eif2ak3	Protein kinase domain-containing protein. (1095 aa)
	prr7	Proline rich 7, synaptic. (249 aa)
	mgmt	O-6-methylguanine-DNA methyltransferase. (209 aa)
	tfap4	BHLH domain-containing protein. (328 aa)
	LOC113579747	GRAM domain-containing protein. (650 aa)
	Bcl2l11	Bclx_interact domain-containing protein. (195 aa)
	LOC113572942	Uncharacterized protein. (795 aa)
	fnip1	UDENN FNIP1/2-type domain-containing protein. (1163 aa)
	BIRC5	Uncharacterized protein. (141 aa)
	ENSEEEP00000048570	Nerve growth factor receptor b. (438 aa)
	dhcr24	FAD-binding PCMH-type domain-containing protein. (516 aa)
	ENSEEEP00000049541	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (236 aa)
	LOC113579817	Uncharacterized protein. (205 aa)
	LOC113574726	Uncharacterized protein. (350 aa)
	casp9	Uncharacterized protein; Belongs to the peptidase C14A family. (436 aa)
	sfrp2	Uncharacterized protein. (291 aa)
	LOC113576367	Non-specific serine/threonine protein kinase. (522 aa)
	LOC113583104	RING-type domain-containing protein. (415 aa)

Your Current Organism:

Electrophorus electricus

NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BIRC5	ENSEEEP00000023204	ENSEEEP00000048439	ENSEEEP00000023204	Uncharacterized protein.	Caspase 8, apoptosis-related cysteine peptidase, like 2; Belongs to the peptidase C14A family.	0.427
BIRC5	LOC113574024	ENSEEEP00000048439	ENSEEEP00000042115	Uncharacterized protein.	Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.427
BIRC5	LOC113574035	ENSEEEP00000048439	ENSEEEP00000042103	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.404
BIRC5	LOC113577703	ENSEEEP00000048439	ENSEEEP00000013522	Uncharacterized protein.	CASP8 and FADD-like apoptosis regulator a; Belongs to the peptidase C14A family.	0.406
BIRC5	LOC113587637	ENSEEEP00000048439	ENSEEEP00000007009	Uncharacterized protein.	Uncharacterized protein.	0.970
BIRC5	LOC113588302	ENSEEEP00000048439	ENSEEEP00000025580	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.404
BIRC5	casp2	ENSEEEP00000048439	ENSEEEP00000041606	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.478
BIRC5	casp9	ENSEEEP00000048439	ENSEEEP00000050572	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.630
BIRC5	cflar	ENSEEEP00000048439	ENSEEEP00000015094	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.406
BIRC5	ctsh	ENSEEEP00000048439	ENSEEEP00000035049	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.658
BIRC5	diablo	ENSEEEP00000048439	ENSEEEP00000005777	Uncharacterized protein.	Uncharacterized protein.	0.970
BIRC5	esco2	ENSEEEP00000048439	ENSEEEP00000036767	Uncharacterized protein.	Establishment of sister chromatid cohesion N-acetyltransferase 2.	0.440
BIRC5	xiap	ENSEEEP00000048439	ENSEEEP00000035197	Uncharacterized protein.	RING-type domain-containing protein.	0.622
Bcl2l11	LOC113578802	ENSEEEP00000046201	ENSEEEP00000038538	Bclx_interact domain-containing protein.	Uncharacterized protein.	0.993
Bcl2l11	LOC113579817	ENSEEEP00000046201	ENSEEEP00000049620	Bclx_interact domain-containing protein.	Uncharacterized protein.	0.697
Bcl2l11	LOC113586001	ENSEEEP00000046201	ENSEEEP00000004152	Bclx_interact domain-containing protein.	Uncharacterized protein.	0.724
Bcl2l11	LOC113589104	ENSEEEP00000046201	ENSEEEP00000036817	Bclx_interact domain-containing protein.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.587
Bcl2l11	bax	ENSEEEP00000046201	ENSEEEP00000006826	Bclx_interact domain-containing protein.	BCL2 associated X, apoptosis regulator a.	0.905
Bcl2l11	casp9	ENSEEEP00000046201	ENSEEEP00000050572	Bclx_interact domain-containing protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.571
ENSEEEP00000001199	LOC113574078	ENSEEEP00000001199	ENSEEEP00000042739	Uncharacterized protein.	Uveal autoantigen with coiled-coil domains and ankyrin repeats b.	0.412