(18 nodes) Clathrin-coated endocytic vesicle network (Electrophorus electricus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	inpp5f	Uncharacterized protein. (1135 aa)
	dct	Dopachrome tautomerase. (528 aa)
	LOC113588412	MFS domain-containing protein. (525 aa)
	ap2s1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (143 aa)
	slc18a3	MFS domain-containing protein. (515 aa)
	LOC113576954	Adaptor related protein complex 2 subunit mu 1b; Belongs to the adaptor complexes medium subunit family. (459 aa)
	lmbrd1	LMBR1 domain containing 1. (555 aa)
	ap2a1	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (958 aa)
	LOC113580870	Uncharacterized protein. (209 aa)
	tyrp1	Tyrosinase-related protein 1a. (542 aa)
	LOC113584925	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1691 aa)
	LOC113586066	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (952 aa)
	LOC113584900	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1656 aa)
	LOC113584373	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1678 aa)
	RAB35	Uncharacterized protein. (199 aa)
	LOC113592118	RAB35, member RAS oncogene family b. (199 aa)
	LOC113570083	Adaptor related protein complex 2 subunit mu 1a; Belongs to the adaptor complexes medium subunit family. (440 aa)
	ENSEEEP00000016852	Tyrosinase-related protein 1b. (543 aa)

Your Current Organism:

Electrophorus electricus

NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC113570083	LOC113584373	ENSEEEP00000020811	ENSEEEP00000006238	Adaptor related protein complex 2 subunit mu 1a; Belongs to the adaptor complexes medium subunit family.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.932
LOC113570083	LOC113584900	ENSEEEP00000020811	ENSEEEP00000004661	Adaptor related protein complex 2 subunit mu 1a; Belongs to the adaptor complexes medium subunit family.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.784
LOC113570083	LOC113584925	ENSEEEP00000020811	ENSEEEP00000009955	Adaptor related protein complex 2 subunit mu 1a; Belongs to the adaptor complexes medium subunit family.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.932
LOC113570083	LOC113586066	ENSEEEP00000020811	ENSEEEP00000007482	Adaptor related protein complex 2 subunit mu 1a; Belongs to the adaptor complexes medium subunit family.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.940
LOC113570083	ap2a1	ENSEEEP00000020811	ENSEEEP00000033800	Adaptor related protein complex 2 subunit mu 1a; Belongs to the adaptor complexes medium subunit family.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.940
LOC113570083	ap2s1	ENSEEEP00000020811	ENSEEEP00000043671	Adaptor related protein complex 2 subunit mu 1a; Belongs to the adaptor complexes medium subunit family.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.997
LOC113576954	LOC113584373	ENSEEEP00000050273	ENSEEEP00000006238	Adaptor related protein complex 2 subunit mu 1b; Belongs to the adaptor complexes medium subunit family.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.784
LOC113576954	LOC113584900	ENSEEEP00000050273	ENSEEEP00000004661	Adaptor related protein complex 2 subunit mu 1b; Belongs to the adaptor complexes medium subunit family.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.784
LOC113576954	LOC113584925	ENSEEEP00000050273	ENSEEEP00000009955	Adaptor related protein complex 2 subunit mu 1b; Belongs to the adaptor complexes medium subunit family.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.784
LOC113576954	LOC113586066	ENSEEEP00000050273	ENSEEEP00000007482	Adaptor related protein complex 2 subunit mu 1b; Belongs to the adaptor complexes medium subunit family.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.940
LOC113576954	ap2a1	ENSEEEP00000050273	ENSEEEP00000033800	Adaptor related protein complex 2 subunit mu 1b; Belongs to the adaptor complexes medium subunit family.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.940
LOC113576954	ap2s1	ENSEEEP00000050273	ENSEEEP00000043671	Adaptor related protein complex 2 subunit mu 1b; Belongs to the adaptor complexes medium subunit family.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.985
LOC113580870	RAB35	ENSEEEP00000028649	ENSEEEP00000003785	Uncharacterized protein.	Uncharacterized protein.	0.901
LOC113584373	LOC113570083	ENSEEEP00000006238	ENSEEEP00000020811	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Adaptor related protein complex 2 subunit mu 1a; Belongs to the adaptor complexes medium subunit family.	0.932
LOC113584373	LOC113576954	ENSEEEP00000006238	ENSEEEP00000050273	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Adaptor related protein complex 2 subunit mu 1b; Belongs to the adaptor complexes medium subunit family.	0.784
LOC113584373	LOC113584925	ENSEEEP00000006238	ENSEEEP00000009955	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.901
LOC113584373	LOC113586066	ENSEEEP00000006238	ENSEEEP00000007482	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.691
LOC113584373	ap2a1	ENSEEEP00000006238	ENSEEEP00000033800	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.691
LOC113584373	ap2s1	ENSEEEP00000006238	ENSEEEP00000043671	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.950
LOC113584900	LOC113570083	ENSEEEP00000004661	ENSEEEP00000020811	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Adaptor related protein complex 2 subunit mu 1a; Belongs to the adaptor complexes medium subunit family.	0.784