(24 nodes) Regulation of endothelial cell differentiation network (Electrophorus electricus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Proc	Uncharacterized protein. (416 aa)
	LOC113582049	Uncharacterized protein. (1131 aa)
	ENSEEEP00000050153	Si:cabz01007807.1. (295 aa)
	rock2	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1397 aa)
	LOC113575300	Uncharacterized protein. (410 aa)
	LOC113584063	Interleukin-1. (271 aa)
	LOC113588453	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (752 aa)
	TMEM100	Transmembrane protein 100. (147 aa)
	zdhhc21	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (262 aa)
	LOC113587998	Uncharacterized protein. (176 aa)
	tal1	BHLH domain-containing protein. (348 aa)
	krit1	Uncharacterized protein. (741 aa)
	f11r	F11 receptor, tandem duplicate 1. (265 aa)
	ENSEEEP00000026884	Apolipoprotein L, 1. (296 aa)
	ENSEEEP00000023023	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (287 aa)
	rock1	Rho-associated, coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1286 aa)
	cldn5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	HHEX	Homeobox domain-containing protein. (268 aa)
	ID1	BHLH domain-containing protein. (131 aa)
	LOC113591262	Vinculin b. (1104 aa)
	LOC113577728	Uncharacterized protein. (691 aa)
	LOC113567830	BHLH domain-containing protein. (130 aa)
	ENSEEEP00000009508	Uncharacterized protein. (273 aa)
	LOC113583225	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (239 aa)

Your Current Organism:

Electrophorus electricus

NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HHEX	tal1	ENSEEEP00000020607	ENSEEEP00000036117	Homeobox domain-containing protein.	BHLH domain-containing protein.	0.408
LOC113575300	LOC113584063	ENSEEEP00000044926	ENSEEEP00000044701	Uncharacterized protein.	Interleukin-1.	0.670
LOC113577728	tal1	ENSEEEP00000014039	ENSEEEP00000036117	Uncharacterized protein.	BHLH domain-containing protein.	0.442
LOC113582049	LOC113588453	ENSEEEP00000050538	ENSEEEP00000043546	Uncharacterized protein.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.614
LOC113583225	LOC113584063	ENSEEEP00000004104	ENSEEEP00000044701	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Interleukin-1.	0.420
LOC113583225	LOC113588453	ENSEEEP00000004104	ENSEEEP00000043546	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.676
LOC113583225	cldn5	ENSEEEP00000004104	ENSEEEP00000022020	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.654
LOC113583225	f11r	ENSEEEP00000004104	ENSEEEP00000031034	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	F11 receptor, tandem duplicate 1.	0.501
LOC113584063	LOC113575300	ENSEEEP00000044701	ENSEEEP00000044926	Interleukin-1.	Uncharacterized protein.	0.670
LOC113584063	LOC113583225	ENSEEEP00000044701	ENSEEEP00000004104	Interleukin-1.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.420
LOC113584063	cldn5	ENSEEEP00000044701	ENSEEEP00000022020	Interleukin-1.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.420
LOC113588453	LOC113582049	ENSEEEP00000043546	ENSEEEP00000050538	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Uncharacterized protein.	0.614
LOC113588453	LOC113583225	ENSEEEP00000043546	ENSEEEP00000004104	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.676
LOC113588453	LOC113591262	ENSEEEP00000043546	ENSEEEP00000018507	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Vinculin b.	0.614
LOC113588453	cldn5	ENSEEEP00000043546	ENSEEEP00000022020	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.676
LOC113588453	f11r	ENSEEEP00000043546	ENSEEEP00000031034	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	F11 receptor, tandem duplicate 1.	0.447
LOC113588453	krit1	ENSEEEP00000043546	ENSEEEP00000033917	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Uncharacterized protein.	0.450
LOC113591262	LOC113588453	ENSEEEP00000018507	ENSEEEP00000043546	Vinculin b.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.614
cldn5	LOC113583225	ENSEEEP00000022020	ENSEEEP00000004104	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.654
cldn5	LOC113584063	ENSEEEP00000022020	ENSEEEP00000044701	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Interleukin-1.	0.420