(88 nodes) Positive regulation of angiogenesis network (Electrophorus electricus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC113578141	SAM and SH3 domain containing 1b. (1014 aa)
	ENSEEEP00000039748	PDGF_2 domain-containing protein. (87 aa)
	LOC113583627	Heat shock protein, alpha-crystallin-related, b15; Belongs to the small heat shock protein (HSP20) family. (194 aa)
	LOC113587998	Uncharacterized protein. (176 aa)
	LOC113577807	Cholinergic receptor, nicotinic, alpha 7 (neuronal). (497 aa)
	adm2	Uncharacterized protein. (179 aa)
	il10	Uncharacterized protein. (180 aa)
	ENSEEEP00000037429	Uncharacterized protein. (115 aa)
	LOC113582508	Uncharacterized protein. (747 aa)
	F3	Uncharacterized protein. (286 aa)
	ENSEEEP00000035605	Placental growth factor b; Belongs to the PDGF/VEGF growth factor family. (134 aa)
	tie1	Uncharacterized protein. (1083 aa)
	xbp1	BZIP domain-containing protein. (262 aa)
	LOC113568525	C-C motif chemokine. (105 aa)
	ENSEEEP00000015983	C-C motif chemokine. (106 aa)
	ENSEEEP00000015501	Uncharacterized protein. (1526 aa)
	utp15	Utp15, U3 small nucleolar ribonucleoprotein, homolog. (522 aa)
	LOC113591515	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
	LOC113572604	Si:ch211-39a7.1. (486 aa)
	LOC113590059	Uncharacterized protein. (209 aa)
	gab1	GRB2-associated binding protein 1. (405 aa)
	fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (156 aa)
	ENSEEEP00000010913	Integrin beta; Belongs to the integrin beta chain family. (532 aa)
	LOC113581038	Uncharacterized protein. (1018 aa)
	vegfd	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (311 aa)
	tnn	Tenascin N. (958 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	LOC113579900	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (522 aa)
	LOC113581577	Uncharacterized protein. (355 aa)
	LOC113569070	G_PROTEIN_RECEP_F1_2 domain-containing protein. (187 aa)
	sirt6	Deacetylase sirtuin-type domain-containing protein. (396 aa)
	ENSEEEP00000000461	Uncharacterized protein. (126 aa)
	ninj1	Ninjurin 1. (142 aa)
	JMJD8	JmjC domain-containing protein. (264 aa)
	DDAH1	Dimethylarginine dimethylaminohydrolase 1. (268 aa)
	Mtdh	Uncharacterized protein. (139 aa)
	LOC113586234	C3H1-type domain-containing protein. (589 aa)
	LOC113587949	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (372 aa)
	LOC113581132	Junction plakoglobin b. (687 aa)
	ENSEEEP00000033779	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	ENSEEEP00000034723	Vascular endothelial growth factor Ba; Belongs to the PDGF/VEGF growth factor family. (135 aa)
	LOC113575586	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (208 aa)
	ctsh	Uncharacterized protein; Belongs to the peptidase C1 family. (347 aa)
	emilin1	Uncharacterized protein. (1074 aa)
	bmper	Uncharacterized protein. (678 aa)
	Tbxa2r	Thromboxane A2 receptor. (363 aa)
	serpine1	SERPIN domain-containing protein; Belongs to the serpin family. (410 aa)
	LOC113588279	Si:ch73-380n15.2. (488 aa)
	sash1	SAM and SH3 domain containing 1a. (1161 aa)
	ENSEEEP00000023828	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (452 aa)
	LOC113574430	Metadherin b. (489 aa)
	LOC113588254	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (262 aa)
	LOC113588255	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (270 aa)
	LOC113581282	Coagulation factor IIIa. (285 aa)
	LOC113588252	Aquaporin 1a (Colton blood group), tandem duplicate 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
	angptl3	Fibrinogen C-terminal domain-containing protein. (462 aa)
	ENSEEEP00000022336	Si:ch73-334d15.2. (154 aa)
	LOC113570151	Fibrinogen C-terminal domain-containing protein. (438 aa)
	LOC113578974	Vascular endothelial growth factor Aa; Belongs to the PDGF/VEGF growth factor family. (189 aa)
	nfe2l2	Nuclear factor, erythroid 2-like 2a. (545 aa)
	mydgf	Uncharacterized protein. (172 aa)
	Apela	Apelin receptor early endogenous ligand. (36 aa)
	LOC113589070	Uncharacterized protein. (286 aa)
	sirt1	Deacetylase sirtuin-type domain-containing protein. (729 aa)
	aggf1	Angiogenic factor with G patch and FHA domains 1. (593 aa)
	tgfbr2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (605 aa)
	sp1	Uncharacterized protein. (679 aa)
	ENSEEEP00000051647	Apelin receptor b; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	sfrp2	Uncharacterized protein. (291 aa)
	c5	Complement component 5. (1681 aa)
	vegfa	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (239 aa)
	zc3h12a	C3H1-type domain-containing protein. (598 aa)
	LOC113576322	Uncharacterized protein. (295 aa)
	vegfc	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (403 aa)
	LOC113588675	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	ENSEEEP00000049206	Uncharacterized protein. (873 aa)
	LOC113576847	RING-type domain-containing protein. (995 aa)
	tek	Uncharacterized protein. (1125 aa)
	GREM1	Gremlin 1, DAN family BMP antagonist. (166 aa)
	ENSEEEP00000046537	BZIP domain-containing protein. (314 aa)
	ENSEEEP00000046411	Cytochrome P450, family 1, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (526 aa)
	ENSEEEP00000046407	Uncharacterized protein. (178 aa)
	LOC113584063	Interleukin-1. (271 aa)
	lrrc66	LRRCT domain-containing protein. (329 aa)
	LOC113588453	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (752 aa)
	ENSEEEP00000041531	Extracellular matrix protein 1b. (438 aa)
	kdr	Kinase insert domain receptor (a type III receptor tyrosine kinase); Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1321 aa)
	LOC113583653	Uncharacterized protein. (526 aa)

Your Current Organism:

Electrophorus electricus

NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Apela	ENSEEEP00000051647	ENSEEEP00000018667	ENSEEEP00000051647	Apelin receptor early endogenous ligand.	Apelin receptor b; Belongs to the G-protein coupled receptor 1 family.	0.869
Apela	LOC113588675	ENSEEEP00000018667	ENSEEEP00000049767	Apelin receptor early endogenous ligand.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.869
ENSEEEP00000010913	tnn	ENSEEEP00000010913	ENSEEEP00000009607	Integrin beta; Belongs to the integrin beta chain family.	Tenascin N.	0.464
ENSEEEP00000015983	il10	ENSEEEP00000015983	ENSEEEP00000037779	C-C motif chemokine.	Uncharacterized protein.	0.439
ENSEEEP00000022336	adm2	ENSEEEP00000022336	ENSEEEP00000038003	Si:ch73-334d15.2.	Uncharacterized protein.	0.616
ENSEEEP00000033779	fgf1	ENSEEEP00000033779	ENSEEEP00000011245	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.525
ENSEEEP00000033779	gab1	ENSEEEP00000033779	ENSEEEP00000011726	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	GRB2-associated binding protein 1.	0.514
ENSEEEP00000033779	kdr	ENSEEEP00000033779	ENSEEEP00000041173	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Kinase insert domain receptor (a type III receptor tyrosine kinase); Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.786
ENSEEEP00000033779	tek	ENSEEEP00000033779	ENSEEEP00000047359	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.751
ENSEEEP00000034723	ENSEEEP00000035605	ENSEEEP00000034723	ENSEEEP00000035605	Vascular endothelial growth factor Ba; Belongs to the PDGF/VEGF growth factor family.	Placental growth factor b; Belongs to the PDGF/VEGF growth factor family.	0.512
ENSEEEP00000034723	kdr	ENSEEEP00000034723	ENSEEEP00000041173	Vascular endothelial growth factor Ba; Belongs to the PDGF/VEGF growth factor family.	Kinase insert domain receptor (a type III receptor tyrosine kinase); Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.671
ENSEEEP00000034723	tek	ENSEEEP00000034723	ENSEEEP00000047359	Vascular endothelial growth factor Ba; Belongs to the PDGF/VEGF growth factor family.	Uncharacterized protein.	0.443
ENSEEEP00000034723	tie1	ENSEEEP00000034723	ENSEEEP00000017768	Vascular endothelial growth factor Ba; Belongs to the PDGF/VEGF growth factor family.	Uncharacterized protein.	0.443
ENSEEEP00000034723	vegfc	ENSEEEP00000034723	ENSEEEP00000049982	Vascular endothelial growth factor Ba; Belongs to the PDGF/VEGF growth factor family.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.568
ENSEEEP00000034723	vegfd	ENSEEEP00000034723	ENSEEEP00000010079	Vascular endothelial growth factor Ba; Belongs to the PDGF/VEGF growth factor family.	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	0.555
ENSEEEP00000035605	ENSEEEP00000034723	ENSEEEP00000035605	ENSEEEP00000034723	Placental growth factor b; Belongs to the PDGF/VEGF growth factor family.	Vascular endothelial growth factor Ba; Belongs to the PDGF/VEGF growth factor family.	0.512
ENSEEEP00000035605	ENSEEEP00000039748	ENSEEEP00000035605	ENSEEEP00000039748	Placental growth factor b; Belongs to the PDGF/VEGF growth factor family.	PDGF_2 domain-containing protein.	0.512
ENSEEEP00000035605	LOC113578974	ENSEEEP00000035605	ENSEEEP00000021483	Placental growth factor b; Belongs to the PDGF/VEGF growth factor family.	Vascular endothelial growth factor Aa; Belongs to the PDGF/VEGF growth factor family.	0.948
ENSEEEP00000035605	kdr	ENSEEEP00000035605	ENSEEEP00000041173	Placental growth factor b; Belongs to the PDGF/VEGF growth factor family.	Kinase insert domain receptor (a type III receptor tyrosine kinase); Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.865
ENSEEEP00000035605	tek	ENSEEEP00000035605	ENSEEEP00000047359	Placental growth factor b; Belongs to the PDGF/VEGF growth factor family.	Uncharacterized protein.	0.815