(72 nodes) Positive regulation of developmental growth network (Electrophorus electricus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC113570376	Cyclin dependent kinase like 5. (799 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	LOC113578756	Colony stimulating factor 1b (macrophage). (287 aa)
	wnt2b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	mul1	RING-type domain-containing protein. (352 aa)
	rufy3	Uncharacterized protein. (668 aa)
	islr2	Immunoglobulin superfamily containing leucine-rich repeat 2. (711 aa)
	sema7a	Semaphorin 7A; Belongs to the semaphorin family. (432 aa)
	ENSEEEP00000002117	Endothelin 1. (99 aa)
	LOC113587081	Uncharacterized protein. (1206 aa)
	ist1	Uncharacterized protein. (354 aa)
	nol12	Uncharacterized protein. (239 aa)
	LOC113575270	Si:ch211-113g11.6; Belongs to the semaphorin family. (581 aa)
	shtn1	Shootin 1. (470 aa)
	ENSEEEP00000044830	Drebrin-like a. (424 aa)
	LOC113572392	Uncharacterized protein. (966 aa)
	ENSEEEP00000021146	Leptin a. (173 aa)
	anapc2	CULLIN_2 domain-containing protein; Belongs to the cullin family. (794 aa)
	bcl2	BH4_2 domain-containing protein. (223 aa)
	nsmf	NMDA receptor synaptonuclear signaling and neuronal migration factor b. (602 aa)
	mkks	Uncharacterized protein. (559 aa)
	LOC113573233	Uncharacterized protein. (234 aa)
	adnp	Activity-dependent neuroprotector homeobox b. (963 aa)
	LOC113591539	Uncharacterized protein; Belongs to the semaphorin family. (579 aa)
	LOC113573821	BCL2, apoptosis regulator a. (209 aa)
	SYT2	Synaptotagmin 2. (427 aa)
	LOC113590080	Synaptotagmin IIa. (431 aa)
	ENSEEEP00000044388	A kinase (PRKA) anchor protein 6. (962 aa)
	hlx	Homeobox domain-containing protein. (372 aa)
	dbn1	Drebrin 1. (540 aa)
	zfyve27	FYVE-type domain-containing protein. (416 aa)
	LOC113571947	Synaptotagmin Vb. (417 aa)
	LOC113576120	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	rnf157	Ring finger protein 157. (636 aa)
	plaa	Phospholipase A2-activating protein. (799 aa)
	LOC113579186	Fibronectin 1b. (2439 aa)
	gpam	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa)
	bmpr2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1011 aa)
	ENSEEEP00000038413	Zinc finger protein, FOG family member 2b. (1049 aa)
	LOC113584274	Fibronectin 1a. (2486 aa)
	LOC113573448	NMDA receptor synaptonuclear signaling and neuronal migration factor a. (405 aa)
	ppib	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
	ENSEEEP00000037529	Bardet-Biedl syndrome 4. (356 aa)
	spast	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...] (598 aa)
	SRF	Serum response factor. (369 aa)
	Srf	Uncharacterized protein. (185 aa)
	ENSEEEP00000036466	Uncharacterized protein. (194 aa)
	wnt3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	LOC113589593	NGF domain-containing protein; Belongs to the NGF-beta family. (198 aa)
	sash3	SH3 domain-containing protein. (373 aa)
	agrn	Agrin. (2000 aa)
	syt1	Uncharacterized protein. (418 aa)
	dbnl	Uncharacterized protein. (474 aa)
	smo	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (826 aa)
	igf1	Insulin-like growth factor 1. (181 aa)
	syt17	Synaptotagmin XVII. (405 aa)
	ENSEEEP00000028378	ADF-H domain-containing protein. (112 aa)
	parp2	Poly [ADP-ribose] polymerase. (572 aa)
	prkn	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (451 aa)
	zfpm2	Uncharacterized protein. (1149 aa)
	LOC113576492	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (360 aa)
	LOC113578261	Cyclin-dependent kinase-like 5. (1065 aa)
	LOC113583078	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (387 aa)
	LOC113581288	L1 cell adhesion molecule, paralog a. (725 aa)
	LOC113589807	Uncharacterized protein. (240 aa)
	LOC113582596	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (992 aa)
	ENSEEEP00000046452	Uncharacterized protein. (569 aa)
	golga4	Golgin A4. (2075 aa)
	ppard	Uncharacterized protein. (410 aa)
	LOC113592285	Uncharacterized protein. (526 aa)
	LOC113587808	NGF domain-containing protein; Belongs to the NGF-beta family. (228 aa)
	LOC113580486	Si:dkey-40c11.2. (716 aa)

Your Current Organism:

Electrophorus electricus

NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish

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structured XML interaction data, according to the 'PSI-MI' data standard

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSEEEP00000002117	ENSEEEP00000021146	ENSEEEP00000002117	ENSEEEP00000021146	Endothelin 1.	Leptin a.	0.497
ENSEEEP00000002117	LOC113576120	ENSEEEP00000002117	ENSEEEP00000042380	Endothelin 1.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.428
ENSEEEP00000002117	LOC113576492	ENSEEEP00000002117	ENSEEEP00000010083	Endothelin 1.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.488
ENSEEEP00000002117	LOC113587808	ENSEEEP00000002117	ENSEEEP00000022545	Endothelin 1.	NGF domain-containing protein; Belongs to the NGF-beta family.	0.416
ENSEEEP00000021146	ENSEEEP00000002117	ENSEEEP00000021146	ENSEEEP00000002117	Leptin a.	Endothelin 1.	0.497
ENSEEEP00000021146	LOC113573821	ENSEEEP00000021146	ENSEEEP00000014809	Leptin a.	BCL2, apoptosis regulator a.	0.410
ENSEEEP00000021146	bcl2	ENSEEEP00000021146	ENSEEEP00000020091	Leptin a.	BH4_2 domain-containing protein.	0.410
ENSEEEP00000021146	igf1	ENSEEEP00000021146	ENSEEEP00000028931	Leptin a.	Insulin-like growth factor 1.	0.580
ENSEEEP00000037529	ENSEEEP00000046452	ENSEEEP00000037529	ENSEEEP00000046452	Bardet-Biedl syndrome 4.	Uncharacterized protein.	0.518
ENSEEEP00000037529	anapc2	ENSEEEP00000037529	ENSEEEP00000020731	Bardet-Biedl syndrome 4.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.579
ENSEEEP00000037529	smo	ENSEEEP00000037529	ENSEEEP00000029491	Bardet-Biedl syndrome 4.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.675
ENSEEEP00000046452	ENSEEEP00000037529	ENSEEEP00000046452	ENSEEEP00000037529	Uncharacterized protein.	Bardet-Biedl syndrome 4.	0.518
LOC113573233	golga4	ENSEEEP00000016353	ENSEEEP00000046327	Uncharacterized protein.	Golgin A4.	0.494
LOC113573821	ENSEEEP00000021146	ENSEEEP00000014809	ENSEEEP00000021146	BCL2, apoptosis regulator a.	Leptin a.	0.410
LOC113576120	ENSEEEP00000002117	ENSEEEP00000042380	ENSEEEP00000002117	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.428
LOC113576120	LOC113576492	ENSEEEP00000042380	ENSEEEP00000010083	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.901
LOC113576492	ENSEEEP00000002117	ENSEEEP00000010083	ENSEEEP00000002117	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.488
LOC113576492	LOC113576120	ENSEEEP00000010083	ENSEEEP00000042380	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.901
LOC113576492	igf1	ENSEEEP00000010083	ENSEEEP00000028931	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Insulin-like growth factor 1.	0.407
LOC113579186	LOC113584274	ENSEEEP00000041491	ENSEEEP00000038302	Fibronectin 1b.	Fibronectin 1a.	0.901