(66 nodes) Branching morphogenesis of an epithelial tube network (Electrophorus electricus)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1806 aa)
	ENSEEEP00000048203	Pept_C1 domain-containing protein. (179 aa)
	ctnnbip1	Catenin, beta interacting protein 1. (112 aa)
	ENSEEEP00000051616	Polycystic kidney disease 1b. (3060 aa)
	sfrp2	Uncharacterized protein. (291 aa)
	LOC113587597	Wilms tumor 1b. (398 aa)
	ENSEEEP00000001488	Mothers against decapentaplegic homolog. (440 aa)
	LOC113578175	Homeobox domain-containing protein. (207 aa)
	ENSEEEP00000002117	Endothelin 1. (99 aa)
	ENSEEEP00000004026	Uncharacterized protein. (394 aa)
	LOC113578756	Colony stimulating factor 1b (macrophage). (287 aa)
	LOC113590492	Transforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
	tmem59l	Transmembrane protein 59-like. (317 aa)
	LOC113573801	Transforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
	LOC113570313	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (459 aa)
	LOC113581577	Uncharacterized protein. (355 aa)
	Greb1	Uncharacterized protein. (255 aa)
	Spry1	Sprouty homolog 1, antagonist of FGF signaling (Drosophila). (197 aa)
	fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (156 aa)
	ENSEEEP00000011251	Nuclear receptor domain-containing protein. (558 aa)
	wnt6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
	dlg5	Discs, large homolog 5a (Drosophila); Belongs to the MAGUK family. (1950 aa)
	LOC113591515	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
	LOC113578874	Peptidase S72 domain-containing protein. (845 aa)
	wt1	Uncharacterized protein. (413 aa)
	LOC113567946	Mothers against decapentaplegic homolog. (524 aa)
	hhip	Hedgehog interacting protein. (462 aa)
	timeless	Timeless circadian clock. (1201 aa)
	Lef1	Lymphoid enhancer-binding factor 1. (212 aa)
	ENSEEEP00000019748	Uncharacterized protein. (450 aa)
	gdnf	Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. (244 aa)
	smad4	Mothers against decapentaplegic homolog. (545 aa)
	dag1	Peptidase S72 domain-containing protein. (861 aa)
	ednra	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (435 aa)
	LOC113578974	Vascular endothelial growth factor Aa; Belongs to the PDGF/VEGF growth factor family. (189 aa)
	sema3a	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ab; Belongs to the semaphorin family. (779 aa)
	cited1	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1. (145 aa)
	nrarp	ANK_REP_REGION domain-containing protein. (112 aa)
	LOC113590604	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (552 aa)
	ENSEEEP00000025096	NR LBD domain-containing protein. (205 aa)
	ilk	Integrin-linked kinase. (482 aa)
	LOC113586846	BHLH domain-containing protein. (176 aa)
	sars1	AA_TRNA_LIGASE_II domain-containing protein. (516 aa)
	Nfatc4	RHD domain-containing protein. (165 aa)
	ENSEEEP00000029058	CTNNB1_binding domain-containing protein. (167 aa)
	ENSEEEP00000029377	PLAT domain-containing protein. (205 aa)
	LOC113571196	Mothers against decapentaplegic homolog. (572 aa)
	lrp6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1633 aa)
	LOC113576659	TGF_BETA_2 domain-containing protein. (440 aa)
	rspo2	Uncharacterized protein. (245 aa)
	tcf21	BHLH domain-containing protein. (179 aa)
	ctsh	Uncharacterized protein; Belongs to the peptidase C1 family. (347 aa)
	tgfbr2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (605 aa)
	LOC113579658	Uncharacterized protein. (186 aa)
	ENSEEEP00000036466	Uncharacterized protein. (194 aa)
	Srf	Uncharacterized protein. (185 aa)
	SRF	Serum response factor. (369 aa)
	ENSEEEP00000036876	Sprouty RTK signaling antagonist 2. (281 aa)
	ctsz	Cathepsin Z; Belongs to the peptidase C1 family. (307 aa)
	LOC113567556	Uncharacterized protein. (790 aa)
	ENSEEEP00000038661	Uncharacterized protein. (198 aa)
	gbx2	Homeobox domain-containing protein. (334 aa)
	LOC113590357	Uncharacterized protein. (530 aa)
	LOC113579218	Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (453 aa)
	mks1	Meckel syndrome, type 1. (488 aa)
	LOC113572891	ANK_REP_REGION domain-containing protein. (111 aa)

Your Current Organism:

Electrophorus electricus

NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSEEEP00000001488	LOC113573801	ENSEEEP00000001488	ENSEEEP00000005782	Mothers against decapentaplegic homolog.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.566
ENSEEEP00000001488	LOC113576659	ENSEEEP00000001488	ENSEEEP00000033467	Mothers against decapentaplegic homolog.	TGF_BETA_2 domain-containing protein.	0.605
ENSEEEP00000001488	LOC113590492	ENSEEEP00000001488	ENSEEEP00000004598	Mothers against decapentaplegic homolog.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.566
ENSEEEP00000001488	LOC113590604	ENSEEEP00000001488	ENSEEEP00000022914	Mothers against decapentaplegic homolog.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.571
ENSEEEP00000001488	LOC113591515	ENSEEEP00000001488	ENSEEEP00000013881	Mothers against decapentaplegic homolog.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.610
ENSEEEP00000001488	tgfbr2	ENSEEEP00000001488	ENSEEEP00000052503	Mothers against decapentaplegic homolog.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.610
ENSEEEP00000002117	LOC113570313	ENSEEEP00000002117	ENSEEEP00000005786	Endothelin 1.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.996
ENSEEEP00000002117	ednra	ENSEEEP00000002117	ENSEEEP00000020957	Endothelin 1.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.997
ENSEEEP00000004026	LOC113578175	ENSEEEP00000004026	ENSEEEP00000001956	Uncharacterized protein.	Homeobox domain-containing protein.	0.463
ENSEEEP00000004026	med1	ENSEEEP00000004026	ENSEEEP00000047901	Uncharacterized protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.546
ENSEEEP00000011251	ENSEEEP00000025096	ENSEEEP00000011251	ENSEEEP00000025096	Nuclear receptor domain-containing protein.	NR LBD domain-containing protein.	0.917
ENSEEEP00000011251	LOC113578175	ENSEEEP00000011251	ENSEEEP00000001956	Nuclear receptor domain-containing protein.	Homeobox domain-containing protein.	0.463
ENSEEEP00000011251	med1	ENSEEEP00000011251	ENSEEEP00000047901	Nuclear receptor domain-containing protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.546
ENSEEEP00000019748	wnt6	ENSEEEP00000019748	ENSEEEP00000011999	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.409
ENSEEEP00000025096	ENSEEEP00000011251	ENSEEEP00000025096	ENSEEEP00000011251	NR LBD domain-containing protein.	Nuclear receptor domain-containing protein.	0.917
ENSEEEP00000025096	LOC113578175	ENSEEEP00000025096	ENSEEEP00000001956	NR LBD domain-containing protein.	Homeobox domain-containing protein.	0.463
ENSEEEP00000025096	med1	ENSEEEP00000025096	ENSEEEP00000047901	NR LBD domain-containing protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.546
ENSEEEP00000029058	Lef1	ENSEEEP00000029058	ENSEEEP00000018408	CTNNB1_binding domain-containing protein.	Lymphoid enhancer-binding factor 1.	0.452
ENSEEEP00000036876	Spry1	ENSEEEP00000036876	ENSEEEP00000009478	Sprouty RTK signaling antagonist 2.	Sprouty homolog 1, antagonist of FGF signaling (Drosophila).	0.646
ENSEEEP00000038661	wnt6	ENSEEEP00000038661	ENSEEEP00000011999	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.409