(51 nodes) Regulation of insulin secretion network (Electrophorus electricus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC113579817	Uncharacterized protein. (205 aa)
	hmgn3	Uncharacterized protein. (98 aa)
	ENSEEEP00000000934	RabBD domain-containing protein. (114 aa)
	CCN3	Uncharacterized protein. (341 aa)
	syt7	Synaptotagmin VIIb. (488 aa)
	sirt6	Deacetylase sirtuin-type domain-containing protein. (396 aa)
	kcnj8	Uncharacterized protein. (417 aa)
	LOC113588188	Synaptotagmin VIIa. (474 aa)
	nr1d1	Uncharacterized protein. (634 aa)
	mpc2	Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (127 aa)
	LOC113577672	Uncharacterized protein. (142 aa)
	slc8b1	Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (591 aa)
	nr1h4	Uncharacterized protein. (461 aa)
	ENSEEEP00000014738	Si:dkey-211g8.9. (296 aa)
	kcnj11	Uncharacterized protein. (381 aa)
	MIDN	Ubiquitin-like domain-containing protein. (436 aa)
	rfx6	Regulatory factor X, 6. (887 aa)
	capn10	Calpain 10; Belongs to the peptidase C2 family. (665 aa)
	LOC113584034	Nuclear receptor subfamily 0, group B, member 2b. (266 aa)
	ENSEEEP00000017839	PDZ domain-containing protein. (379 aa)
	aacs	Uncharacterized protein. (683 aa)
	LOC113573315	Regulatory factor X, 3 (influences HLA class II expression). (761 aa)
	LOC113576022	Uncharacterized protein. (129 aa)
	ENSEEEP00000020137	Ghrelin/obestatin prepropeptide. (108 aa)
	mcu	MCU domain-containing protein. (374 aa)
	hadh	Uncharacterized protein. (308 aa)
	ndufaf2	Uncharacterized protein. (161 aa)
	LOC113574912	Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (149 aa)
	pla2g6	Phospholipase A2, group VI (cytosolic, calcium-independent). (821 aa)
	LOC113581705	Uncharacterized protein. (192 aa)
	prkn	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (451 aa)
	LOC113588843	Kruppel-like factor 7a. (266 aa)
	adcy8	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1209 aa)
	pick1	Uncharacterized protein. (413 aa)
	LOC113588323	MCU domain-containing protein. (334 aa)
	syt9	Uncharacterized protein. (518 aa)
	LOC113574407	NR LBD domain-containing protein. (262 aa)
	c2cd2l	C2cd2-like. (707 aa)
	LOC113582560	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (323 aa)
	LOC113570852	Synaptotagmin IXa. (507 aa)
	klf7	Uncharacterized protein. (296 aa)
	LOC113578607	Nuclear receptor subfamily 1, group D, member 4a. (554 aa)
	LOC113574009	Uncharacterized protein. (237 aa)
	LOC113584063	Interleukin-1. (271 aa)
	PIM3	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (324 aa)
	tm7sf3	Transmembrane 7 superfamily member 3. (525 aa)
	LOC113577365	Uncharacterized protein. (486 aa)
	pdx1	Homeobox domain-containing protein. (247 aa)
	LOC113576189	Midnolin. (426 aa)
	BIRC5	Uncharacterized protein. (141 aa)
	psmd9	PDZ domain-containing protein. (213 aa)

Your Current Organism:

Electrophorus electricus

NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC113574009	capn10	ENSEEEP00000041481	ENSEEEP00000016953	Uncharacterized protein.	Calpain 10; Belongs to the peptidase C2 family.	0.428
LOC113574407	LOC113577365	ENSEEEP00000029661	ENSEEEP00000047323	NR LBD domain-containing protein.	Uncharacterized protein.	0.563
LOC113574407	nr1h4	ENSEEEP00000029661	ENSEEEP00000013946	NR LBD domain-containing protein.	Uncharacterized protein.	0.563
LOC113576022	ndufaf2	ENSEEEP00000020058	ENSEEEP00000024192	Uncharacterized protein.	Uncharacterized protein.	0.479
LOC113577365	LOC113574407	ENSEEEP00000047323	ENSEEEP00000029661	Uncharacterized protein.	NR LBD domain-containing protein.	0.563
LOC113577365	LOC113584034	ENSEEEP00000047323	ENSEEEP00000017324	Uncharacterized protein.	Nuclear receptor subfamily 0, group B, member 2b.	0.563
LOC113581705	capn10	ENSEEEP00000026163	ENSEEEP00000016953	Uncharacterized protein.	Calpain 10; Belongs to the peptidase C2 family.	0.428
LOC113584034	LOC113577365	ENSEEEP00000017324	ENSEEEP00000047323	Nuclear receptor subfamily 0, group B, member 2b.	Uncharacterized protein.	0.563
LOC113584034	nr1h4	ENSEEEP00000017324	ENSEEEP00000013946	Nuclear receptor subfamily 0, group B, member 2b.	Uncharacterized protein.	0.563
LOC113588323	slc8b1	ENSEEEP00000029056	ENSEEEP00000012233	MCU domain-containing protein.	Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.406
aacs	hadh	ENSEEEP00000019517	ENSEEEP00000023505	Uncharacterized protein.	Uncharacterized protein.	0.960
capn10	LOC113574009	ENSEEEP00000016953	ENSEEEP00000041481	Calpain 10; Belongs to the peptidase C2 family.	Uncharacterized protein.	0.428
capn10	LOC113581705	ENSEEEP00000016953	ENSEEEP00000026163	Calpain 10; Belongs to the peptidase C2 family.	Uncharacterized protein.	0.428
hadh	aacs	ENSEEEP00000023505	ENSEEEP00000019517	Uncharacterized protein.	Uncharacterized protein.	0.960
mcu	slc8b1	ENSEEEP00000021272	ENSEEEP00000012233	MCU domain-containing protein.	Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.406
ndufaf2	LOC113576022	ENSEEEP00000024192	ENSEEEP00000020058	Uncharacterized protein.	Uncharacterized protein.	0.479
nr1h4	LOC113574407	ENSEEEP00000013946	ENSEEEP00000029661	Uncharacterized protein.	NR LBD domain-containing protein.	0.563
nr1h4	LOC113584034	ENSEEEP00000013946	ENSEEEP00000017324	Uncharacterized protein.	Nuclear receptor subfamily 0, group B, member 2b.	0.563
pdx1	rfx6	ENSEEEP00000047454	ENSEEEP00000015056	Homeobox domain-containing protein.	Regulatory factor X, 6.	0.400
pla2g6	prkn	ENSEEEP00000025787	ENSEEEP00000026210	Phospholipase A2, group VI (cytosolic, calcium-independent).	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.406