(29 nodes) Negative regulation of synaptic transmission network (Electrophorus electricus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSEEEP00000034527	SH3 and multiple ankyrin repeat domains 2. (1426 aa)
	fmr1	Uncharacterized protein. (587 aa)
	Srf	Uncharacterized protein. (185 aa)
	SRF	Serum response factor. (369 aa)
	LOC113583549	Solute carrier family 24 (sodium/potassium/calcium exchanger), member 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (625 aa)
	tmem25	Ig-like domain-containing protein. (380 aa)
	LOC113581235	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (409 aa)
	pnkd	PNKD, MBL domain containing. (382 aa)
	ENSEEEP00000047715	Si:ch73-71c20.5. (153 aa)
	ENSEEEP00000048131	Solute carrier family 24 (sodium/potassium/calcium exchanger), member 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (699 aa)
	SHANK2	SH3 and multiple ankyrin repeat domains 2. (1411 aa)
	pick1	Uncharacterized protein. (413 aa)
	abhd6	AB hydrolase-1 domain-containing protein. (339 aa)
	LOC113586523	Uncharacterized protein. (197 aa)
	prkn	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (451 aa)
	LOC113584523	Uncharacterized protein. (2778 aa)
	pla2g6	Phospholipase A2, group VI (cytosolic, calcium-independent). (821 aa)
	LOC113572392	Uncharacterized protein. (966 aa)
	grid2ip	Glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein, b. (985 aa)
	PRRT1	Proline rich transmembrane protein 1. (93 aa)
	adnp	Activity-dependent neuroprotector homeobox b. (963 aa)
	ENSEEEP00000011953	AB hydrolase-1 domain-containing protein. (297 aa)
	tnr	Tenascin R (restrictin, janusin). (1345 aa)
	LOC113573207	Glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein, a. (1104 aa)
	ENSEEEP00000007672	Na_Ca_ex domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (276 aa)
	rap1a	Uncharacterized protein. (185 aa)
	lrrk2	Leucine-rich repeat kinase 2. (2512 aa)
	ENSEEEP00000001081	G_PROTEIN_RECEP_F1_2 domain-containing protein. (114 aa)
	rap1b	Uncharacterized protein. (199 aa)

Your Current Organism:

Electrophorus electricus

NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC113584523	LOC113586523	ENSEEEP00000025849	ENSEEEP00000027543	Uncharacterized protein.	Uncharacterized protein.	0.657
LOC113584523	rap1a	ENSEEEP00000025849	ENSEEEP00000004047	Uncharacterized protein.	Uncharacterized protein.	0.657
LOC113584523	rap1b	ENSEEEP00000025849	ENSEEEP00000000316	Uncharacterized protein.	Uncharacterized protein.	0.657
LOC113586523	LOC113584523	ENSEEEP00000027543	ENSEEEP00000025849	Uncharacterized protein.	Uncharacterized protein.	0.657
SRF	Srf	ENSEEEP00000036505	ENSEEEP00000036504	Serum response factor.	Uncharacterized protein.	0.900
Srf	SRF	ENSEEEP00000036504	ENSEEEP00000036505	Uncharacterized protein.	Serum response factor.	0.900
lrrk2	prkn	ENSEEEP00000003360	ENSEEEP00000026210	Leucine-rich repeat kinase 2.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.630
pick1	tmem25	ENSEEEP00000028302	ENSEEEP00000041206	Uncharacterized protein.	Ig-like domain-containing protein.	0.442
pla2g6	prkn	ENSEEEP00000025787	ENSEEEP00000026210	Phospholipase A2, group VI (cytosolic, calcium-independent).	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.406
prkn	lrrk2	ENSEEEP00000026210	ENSEEEP00000003360	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Leucine-rich repeat kinase 2.	0.630
prkn	pla2g6	ENSEEEP00000026210	ENSEEEP00000025787	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Phospholipase A2, group VI (cytosolic, calcium-independent).	0.406
rap1a	LOC113584523	ENSEEEP00000004047	ENSEEEP00000025849	Uncharacterized protein.	Uncharacterized protein.	0.657
rap1b	LOC113584523	ENSEEEP00000000316	ENSEEEP00000025849	Uncharacterized protein.	Uncharacterized protein.	0.657
tmem25	pick1	ENSEEEP00000041206	ENSEEEP00000028302	Ig-like domain-containing protein.	Uncharacterized protein.	0.442