(23 nodes) Chromosome separation network (Electrophorus electricus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSEEEP00000027935	Extra spindle pole bodies like 1, separase. (1648 aa)
	eme1	Essential meiotic structure-specific endonuclease 1. (550 aa)
	ttk	Ttk protein kinase. (848 aa)
	top2b	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1600 aa)
	hfm1	HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae). (1040 aa)
	LOC113582703	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1597 aa)
	mus81	MUS81 structure-specific endonuclease subunit. (615 aa)
	ENSEEEP00000037636	Helicase C-terminal domain-containing protein. (432 aa)
	ENSEEEP00000037634	ERCC4 domain-containing protein. (1166 aa)
	Recql5	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (970 aa)
	cenpx	Uncharacterized protein. (81 aa)
	ankle1	Zgc:85936. (862 aa)
	ncaph	Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (695 aa)
	ENSEEEP00000029998	Uncharacterized protein. (608 aa)
	ercc4	ERCC4 domain-containing protein. (899 aa)
	ENSEEEP00000019307	Uncharacterized protein. (258 aa)
	ENSEEEP00000018543	Methionine sulfoxide reductase B1b. (259 aa)
	ENSEEEP00000016716	Helicase ATP-binding domain-containing protein. (320 aa)
	mlh1	DNA_mis_repair domain-containing protein. (724 aa)
	ncaph2	Uncharacterized protein. (586 aa)
	top3a	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1009 aa)
	dis3l2	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation. Belongs to the RNR ribonuclease family. DIS3L2 subfamily. (923 aa)
	rmi1	DUF1767 domain-containing protein. (587 aa)

Your Current Organism:

Electrophorus electricus

NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSEEEP00000016716	ENSEEEP00000018543	ENSEEEP00000016716	ENSEEEP00000018543	Helicase ATP-binding domain-containing protein.	Methionine sulfoxide reductase B1b.	0.998
ENSEEEP00000016716	ENSEEEP00000019307	ENSEEEP00000016716	ENSEEEP00000019307	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.910
ENSEEEP00000016716	ENSEEEP00000029998	ENSEEEP00000016716	ENSEEEP00000029998	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.621
ENSEEEP00000016716	ENSEEEP00000037634	ENSEEEP00000016716	ENSEEEP00000037634	Helicase ATP-binding domain-containing protein.	ERCC4 domain-containing protein.	0.990
ENSEEEP00000016716	ENSEEEP00000037636	ENSEEEP00000016716	ENSEEEP00000037636	Helicase ATP-binding domain-containing protein.	Helicase C-terminal domain-containing protein.	0.993
ENSEEEP00000016716	LOC113582703	ENSEEEP00000016716	ENSEEEP00000044755	Helicase ATP-binding domain-containing protein.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.534
ENSEEEP00000016716	Recql5	ENSEEEP00000016716	ENSEEEP00000037591	Helicase ATP-binding domain-containing protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.997
ENSEEEP00000016716	cenpx	ENSEEEP00000016716	ENSEEEP00000037528	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.694
ENSEEEP00000016716	eme1	ENSEEEP00000016716	ENSEEEP00000051609	Helicase ATP-binding domain-containing protein.	Essential meiotic structure-specific endonuclease 1.	0.622
ENSEEEP00000016716	ercc4	ENSEEEP00000016716	ENSEEEP00000020903	Helicase ATP-binding domain-containing protein.	ERCC4 domain-containing protein.	0.718
ENSEEEP00000016716	hfm1	ENSEEEP00000016716	ENSEEEP00000044990	Helicase ATP-binding domain-containing protein.	HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae).	0.514
ENSEEEP00000016716	mlh1	ENSEEEP00000016716	ENSEEEP00000016195	Helicase ATP-binding domain-containing protein.	DNA_mis_repair domain-containing protein.	0.703
ENSEEEP00000016716	mus81	ENSEEEP00000016716	ENSEEEP00000042552	Helicase ATP-binding domain-containing protein.	MUS81 structure-specific endonuclease subunit.	0.998
ENSEEEP00000016716	rmi1	ENSEEEP00000016716	ENSEEEP00000003636	Helicase ATP-binding domain-containing protein.	DUF1767 domain-containing protein.	0.997
ENSEEEP00000016716	top2b	ENSEEEP00000016716	ENSEEEP00000048124	Helicase ATP-binding domain-containing protein.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.534
ENSEEEP00000016716	top3a	ENSEEEP00000016716	ENSEEEP00000010660	Helicase ATP-binding domain-containing protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.997
ENSEEEP00000016716	ttk	ENSEEEP00000016716	ENSEEEP00000048679	Helicase ATP-binding domain-containing protein.	Ttk protein kinase.	0.475
ENSEEEP00000018543	ENSEEEP00000016716	ENSEEEP00000018543	ENSEEEP00000016716	Methionine sulfoxide reductase B1b.	Helicase ATP-binding domain-containing protein.	0.998
ENSEEEP00000018543	ENSEEEP00000029998	ENSEEEP00000018543	ENSEEEP00000029998	Methionine sulfoxide reductase B1b.	Uncharacterized protein.	0.422
ENSEEEP00000018543	ENSEEEP00000037634	ENSEEEP00000018543	ENSEEEP00000037634	Methionine sulfoxide reductase B1b.	ERCC4 domain-containing protein.	0.998