(11 nodes) Embryonic retina morphogenesis in camera-type eye network (Electrophorus electricus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC113592206	Cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins. (953 aa)
	ENSEEEP00000022338	Forkhead box C1b. (207 aa)
	LOC113570723	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (506 aa)
	LOC113586272	TGF_BETA_2 domain-containing protein. (411 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (294 aa)
	ENSEEEP00000051473	Forkhead box C1a. (470 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (721 aa)
	mpp5	Uncharacterized protein; Belongs to the MAGUK family. (708 aa)
	LOC113570819	Uncharacterized protein. (405 aa)
	Gdf5	Growth differentiation factor 5. (510 aa)
	LOC113585459	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)

Your Current Organism:

Electrophorus electricus

NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDH2	LOC113592206	ENSEEEP00000011237	ENSEEEP00000013634	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	Cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins.	0.900
LOC113585459	fgf3	ENSEEEP00000001129	ENSEEEP00000038536	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.792
LOC113592206	CDH2	ENSEEEP00000013634	ENSEEEP00000011237	Cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins.	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	0.900
fgf3	LOC113585459	ENSEEEP00000038536	ENSEEEP00000001129	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.792