(142 nodes) Negative regulation of supramolecular fiber organization network (Electrophorus electricus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSEEEP00000016089	LIM zinc-binding domain-containing protein. (81 aa)
	vill	Villin-like. (833 aa)
	LOC113571875	Uncharacterized protein. (384 aa)
	pfdn6	Uncharacterized protein. (126 aa)
	LOC113586407	Inositol polyphosphate-5-phosphatase Ka. (480 aa)
	ENSEEEP00000043065	SCA7 domain-containing protein. (282 aa)
	lmod2	WH2 domain-containing protein. (532 aa)
	LOC113570399	LIM zinc-binding domain-containing protein. (636 aa)
	LOC113588453	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (752 aa)
	LOC113584785	BMERB domain-containing protein. (180 aa)
	sptan1	Spectrin alpha, non-erythrocytic 1. (2481 aa)
	rhpn1	Rhophilin, Rho GTPase binding protein 1. (606 aa)
	Camsap3	CKK domain-containing protein. (171 aa)
	ENSEEEP00000045279	Uncharacterized protein. (254 aa)
	LOC113571386	Adducin 3 (gamma) b. (715 aa)
	tmod4	Uncharacterized protein. (366 aa)
	LOC113574145	Spectrin beta chain; Belongs to the spectrin family. (2436 aa)
	LOC113574713	Slingshot protein phosphatase 2a. (759 aa)
	capzb	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (277 aa)
	camsap1	Calmodulin regulated spectrin-associated protein 1b. (1523 aa)
	LOC113589770	TACC_C domain-containing protein. (1928 aa)
	ENSEEEP00000049205	Uncharacterized protein. (287 aa)
	ssh1	Slingshot protein phosphatase 1a. (726 aa)
	LOC113583723	Uncharacterized protein. (732 aa)
	ENSEEEP00000051389	Adenomatosis polyposis coli 2. (2450 aa)
	LOC113578105	Twinfilin actin-binding protein 1b. (341 aa)
	ENSEEEP00000051674	Inositol polyphosphate-5-phosphatase Ja. (436 aa)
	LOC113576367	Non-specific serine/threonine protein kinase. (522 aa)
	LOC113576381	Uncharacterized protein. (258 aa)
	LOC113583079	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (284 aa)
	LMOD3	Uncharacterized protein. (701 aa)
	ENSEEEP00000039179	LIM zinc-binding domain-containing protein. (194 aa)
	HDGFL3	PWWP domain-containing protein. (207 aa)
	tbcd	Tubulin folding cofactor D. (1166 aa)
	LOC113571291	Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (50 aa)
	rhpn2	Rhophilin, Rho GTPase binding protein 2. (681 aa)
	LOC113590739	Uncharacterized protein. (51 aa)
	LOC113575175	Uncharacterized protein. (288 aa)
	ENSEEEP00000037539	Zgc:77748. (293 aa)
	ENSEEEP00000037529	Bardet-Biedl syndrome 4. (356 aa)
	cgnl1	Uncharacterized protein. (1305 aa)
	arhgef2	Rho guanine nucleotide exchange factor (GEF) 1a. (897 aa)
	tmod1	Tropomodulin 1. (358 aa)
	clu	Clusterin; Belongs to the clusterin family. (442 aa)
	ENSEEEP00000036431	Inositol polyphosphate-5-phosphatase Kb. (454 aa)
	epcam	Thyroglobulin type-1 domain-containing protein. (305 aa)
	capg	Uncharacterized protein. (392 aa)
	LOC113579076	Uncharacterized protein. (296 aa)
	LOC113570176	Uncharacterized protein. (345 aa)
	pfdn2	Uncharacterized protein. (159 aa)
	LIMA1	LIM zinc-binding domain-containing protein. (710 aa)
	LOC113571196	Mothers against decapentaplegic homolog. (572 aa)
	scin	Scinderin. (773 aa)
	stmn2	Stathmin; Belongs to the stathmin family. (190 aa)
	ENSEEEP00000031422	KN motif and ankyrin repeat domains 1b. (1155 aa)
	LOC113579477	Supervillin d. (1372 aa)
	f11r	F11 receptor, tandem duplicate 1. (265 aa)
	avil	Advillin. (806 aa)
	LOC113582658	Uncharacterized protein. (624 aa)
	LOC113577239	Uncharacterized protein. (207 aa)
	LOC113575524	SCA7 domain-containing protein. (714 aa)
	ENSEEEP00000028548	MAP6 domain containing 1. (233 aa)
	pick1	Uncharacterized protein. (413 aa)
	pfdn5	Uncharacterized protein. (153 aa)
	emilin1	Uncharacterized protein. (1074 aa)
	LOC113570664	Stathmin 2a. (224 aa)
	vil1	HP domain-containing protein. (832 aa)
	ENSEEEP00000027293	Supervillin c. (1071 aa)
	LOC113584158	Uncharacterized protein. (293 aa)
	SPTBN4	Spectrin beta, non-erythrocytic 4. (1183 aa)
	Sptbn4	Uncharacterized protein. (562 aa)
	LOC113588867	Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
	sptbn1	Spectrin beta chain; Belongs to the spectrin family. (2309 aa)
	prkn	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (451 aa)
	apc	Adenomatous polyposis coli. (2709 aa)
	LOC113590308	Uncharacterized protein. (740 aa)
	ENSEEEP00000024819	FERM domain containing 7. (287 aa)
	myoc	Olfactomedin-like domain-containing protein. (470 aa)
	add2	Adducin 2 (beta). (583 aa)
	ENSEEEP00000023378	LIM zinc-binding domain-containing protein. (76 aa)
	chadl	Chondroadherin-like b. (755 aa)
	LOC113587812	KN motif and ankyrin repeat domains 4. (753 aa)
	LOC113570091	ANK_REP_REGION domain-containing protein. (928 aa)
	plekhh2	Pleckstrin homology domain containing, family H (with MyTH4 domain) member 2. (1387 aa)
	ENSEEEP00000021788	PDZ domain-containing protein. (271 aa)
	LOC113572758	Thyroglobulin type-1 domain-containing protein. (304 aa)
	add3	Adducin 3 (gamma) a. (750 aa)
	smad4	Mothers against decapentaplegic homolog. (545 aa)
	atxn7l2	Ataxin 7-like 2a. (726 aa)
	lmod1	WH2 domain-containing protein. (680 aa)
	ENSEEEP00000018442	Uncharacterized protein. (296 aa)
	mkks	Uncharacterized protein. (559 aa)
	ENSEEEP00000017591	FERM_f0 domain-containing protein. (124 aa)
	ENSEEEP00000016983	Uncharacterized protein. (67 aa)
	LOC113584952	Rho/rac guanine nucleotide exchange factor (GEF) 2. (831 aa)
	LOC113567946	Mothers against decapentaplegic homolog. (524 aa)
	atxn7	Ataxin 7. (824 aa)
	SVIL	Supervillin. (1352 aa)
	LOC113591559	Uncharacterized protein. (367 aa)
	LOC113591548	Uncharacterized protein. (757 aa)
	ENSEEEP00000014593	Uncharacterized protein. (635 aa)
	LOC113580523	SH3 and multiple ankyrin repeat domains 3a. (1676 aa)
	gmfb	Glia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (142 aa)
	LOC113572170	Stathmin; Belongs to the stathmin family. (153 aa)
	LOC113579372	Non-specific serine/threonine protein kinase. (540 aa)
	apoe	Uncharacterized protein. (273 aa)
	bmerb1	BMERB domain-containing protein. (199 aa)
	ENSEEEP00000011136	CKK domain-containing protein. (173 aa)
	LOC113581038	Uncharacterized protein. (1018 aa)
	flii	Flightless I actin binding protein. (1259 aa)
	vbp1	Prefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit alpha family. (195 aa)
	LOC113581618	Inositol polyphosphate-5-phosphatase Jb. (453 aa)
	LOC113573266	Zgc:171844. (176 aa)
	pfn4	Profilin; Belongs to the profilin family. (115 aa)
	ENSEEEP00000008658	CKK domain-containing protein. (171 aa)
	ENSEEEP00000008656	Uncharacterized protein. (60 aa)
	ENSEEEP00000008655	Uncharacterized protein. (59 aa)
	camsap2	Calmodulin regulated spectrin-associated protein family, member 2a. (1414 aa)
	LOC113584421	SH3 and multiple ankyrin repeat domains 3b. (1602 aa)
	gsn	Uncharacterized protein. (778 aa)
	kank3	KN motif and ankyrin repeat domains 3. (899 aa)
	LOC113578866	Spectrin beta chain; Belongs to the spectrin family. (2289 aa)
	kank1	ANK_REP_REGION domain-containing protein. (1318 aa)
	LOC113587186	Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (45 aa)
	spef1	Calponin-homology (CH) domain-containing protein. (231 aa)
	Wdr63	Uncharacterized protein. (365 aa)
	LOC113576452	HP domain-containing protein. (97 aa)
	sptbn5	Spectrin, beta, non-erythrocytic 5. (3015 aa)
	ENSEEEP00000004677	Uncharacterized protein. (561 aa)
	LOC113568244	Twinfilin actin-binding protein 2b. (329 aa)
	LOC113589334	Uncharacterized protein. (759 aa)
	LOC113572048	Uncharacterized protein. (709 aa)
	LOC113572074	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
	Add1	Uncharacterized protein. (95 aa)
	add1	Aldolase_II domain-containing protein. (758 aa)
	ENSEEEP00000001488	Mothers against decapentaplegic homolog. (440 aa)
	ENSEEEP00000001199	Uncharacterized protein. (96 aa)
	GMFG	Glia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (142 aa)
	ENSEEEP00000000462	CKK domain-containing protein. (151 aa)
	ENSEEEP00000000091	Uncharacterized protein. (34 aa)
	LOC113583643	Slingshot protein phosphatase 1b. (590 aa)
	LOC113582771	Slingshot protein phosphatase 2b. (1180 aa)

Your Current Organism:

Electrophorus electricus

NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Add1	capzb	ENSEEEP00000003526	ENSEEEP00000046875	Uncharacterized protein.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.449
ENSEEEP00000001199	LOC113588453	ENSEEEP00000001199	ENSEEEP00000043546	Uncharacterized protein.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.470
ENSEEEP00000001199	capzb	ENSEEEP00000001199	ENSEEEP00000046875	Uncharacterized protein.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.406
ENSEEEP00000001199	sptan1	ENSEEEP00000001199	ENSEEEP00000044089	Uncharacterized protein.	Spectrin alpha, non-erythrocytic 1.	0.506
ENSEEEP00000004677	LOC113591548	ENSEEEP00000004677	ENSEEEP00000015089	Uncharacterized protein.	Uncharacterized protein.	0.591
ENSEEEP00000004677	Sptbn4	ENSEEEP00000004677	ENSEEEP00000027021	Uncharacterized protein.	Uncharacterized protein.	0.531
ENSEEEP00000004677	sptan1	ENSEEEP00000004677	ENSEEEP00000044089	Uncharacterized protein.	Spectrin alpha, non-erythrocytic 1.	0.852
ENSEEEP00000014593	LOC113591548	ENSEEEP00000014593	ENSEEEP00000015089	Uncharacterized protein.	Uncharacterized protein.	0.651
ENSEEEP00000014593	Sptbn4	ENSEEEP00000014593	ENSEEEP00000027021	Uncharacterized protein.	Uncharacterized protein.	0.670
ENSEEEP00000014593	sptan1	ENSEEEP00000014593	ENSEEEP00000044089	Uncharacterized protein.	Spectrin alpha, non-erythrocytic 1.	0.845
ENSEEEP00000024819	capzb	ENSEEEP00000024819	ENSEEEP00000046875	FERM domain containing 7.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.471
ENSEEEP00000049205	LOC113576452	ENSEEEP00000049205	ENSEEEP00000004739	Uncharacterized protein.	HP domain-containing protein.	0.504
ENSEEEP00000051389	LOC113576381	ENSEEEP00000051389	ENSEEEP00000051937	Adenomatosis polyposis coli 2.	Uncharacterized protein.	0.479
ENSEEEP00000051389	LOC113579076	ENSEEEP00000051389	ENSEEEP00000034235	Adenomatosis polyposis coli 2.	Uncharacterized protein.	0.479
ENSEEEP00000051389	apc	ENSEEEP00000051389	ENSEEEP00000025236	Adenomatosis polyposis coli 2.	Adenomatous polyposis coli.	0.906
LOC113568244	LOC113570176	ENSEEEP00000004219	ENSEEEP00000033968	Twinfilin actin-binding protein 2b.	Uncharacterized protein.	0.455
LOC113568244	LOC113572074	ENSEEEP00000004219	ENSEEEP00000003972	Twinfilin actin-binding protein 2b.	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.572
LOC113568244	LOC113583079	ENSEEEP00000004219	ENSEEEP00000052223	Twinfilin actin-binding protein 2b.	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.572
LOC113568244	LOC113591559	ENSEEEP00000004219	ENSEEEP00000015170	Twinfilin actin-binding protein 2b.	Uncharacterized protein.	0.461
LOC113568244	capg	ENSEEEP00000004219	ENSEEEP00000035389	Twinfilin actin-binding protein 2b.	Uncharacterized protein.	0.455