(24 nodes) Regulation of double-strand break repair via nonhomologous end joining network (Electrophorus electricus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC113589545	RING-type domain-containing protein. (436 aa)
	wrap53	WD repeat containing, antisense to TP53. (519 aa)
	Aunip	Uncharacterized protein. (237 aa)
	ENSEEEP00000037429	Uncharacterized protein. (115 aa)
	LOC113575774	SET domain-containing protein. (804 aa)
	smchd1	Structural maintenance of chromosomes flexible hinge domain containing 1. (1984 aa)
	ercc6	Excision repair cross-complementation group 6. (1398 aa)
	prkdc	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4099 aa)
	sirt7	Deacetylase sirtuin-type domain-containing protein. (405 aa)
	rif1	Replication timing regulatory factor 1. (2379 aa)
	dtx3	RING-type domain-containing protein. (367 aa)
	LOC113590062	Lysine methyltransferase 5C. (517 aa)
	ENSEEEP00000018711	Zgc:101664. (195 aa)
	pot1	Protection of telomeres 1 homolog. (767 aa)
	LOC113581998	RING-type domain-containing protein. (726 aa)
	pnkp	FHA_2 domain-containing protein. (595 aa)
	Mrnip	Uncharacterized protein. (88 aa)
	parp3	Poly [ADP-ribose] polymerase. (527 aa)
	Nsd2	Uncharacterized protein. (603 aa)
	LOC113573589	SET domain-containing protein. (826 aa)
	ENSEEEP00000045899	PWWP domain-containing protein. (460 aa)
	dek	DEK proto-oncogene. (449 aa)
	LOC113578936	Uncharacterized protein. (296 aa)
	fh	Fumarate hydratase. (493 aa)

Your Current Organism:

Electrophorus electricus

NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSEEEP00000018711	rif1	ENSEEEP00000018711	ENSEEEP00000008598	Zgc:101664.	Replication timing regulatory factor 1.	0.407
ENSEEEP00000045899	Nsd2	ENSEEEP00000045899	ENSEEEP00000045888	PWWP domain-containing protein.	Uncharacterized protein.	0.747
ENSEEEP00000045899	prkdc	ENSEEEP00000045899	ENSEEEP00000052659	PWWP domain-containing protein.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.580
ENSEEEP00000045899	rif1	ENSEEEP00000045899	ENSEEEP00000008598	PWWP domain-containing protein.	Replication timing regulatory factor 1.	0.494
LOC113578936	ercc6	ENSEEEP00000020205	ENSEEEP00000002957	Uncharacterized protein.	Excision repair cross-complementation group 6.	0.445
Nsd2	ENSEEEP00000045899	ENSEEEP00000045888	ENSEEEP00000045899	Uncharacterized protein.	PWWP domain-containing protein.	0.747
Nsd2	prkdc	ENSEEEP00000045888	ENSEEEP00000052659	Uncharacterized protein.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.580
Nsd2	rif1	ENSEEEP00000045888	ENSEEEP00000008598	Uncharacterized protein.	Replication timing regulatory factor 1.	0.494
dek	ercc6	ENSEEEP00000049026	ENSEEEP00000002957	DEK proto-oncogene.	Excision repair cross-complementation group 6.	0.720
ercc6	LOC113578936	ENSEEEP00000002957	ENSEEEP00000020205	Excision repair cross-complementation group 6.	Uncharacterized protein.	0.445
ercc6	dek	ENSEEEP00000002957	ENSEEEP00000049026	Excision repair cross-complementation group 6.	DEK proto-oncogene.	0.720
parp3	prkdc	ENSEEEP00000052156	ENSEEEP00000052659	Poly [ADP-ribose] polymerase.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.511
pnkp	prkdc	ENSEEEP00000050356	ENSEEEP00000052659	FHA_2 domain-containing protein.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.621
pot1	wrap53	ENSEEEP00000018754	ENSEEEP00000032712	Protection of telomeres 1 homolog.	WD repeat containing, antisense to TP53.	0.697
prkdc	ENSEEEP00000045899	ENSEEEP00000052659	ENSEEEP00000045899	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	PWWP domain-containing protein.	0.580
prkdc	Nsd2	ENSEEEP00000052659	ENSEEEP00000045888	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.580
prkdc	parp3	ENSEEEP00000052659	ENSEEEP00000052156	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	Poly [ADP-ribose] polymerase.	0.511
prkdc	pnkp	ENSEEEP00000052659	ENSEEEP00000050356	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	FHA_2 domain-containing protein.	0.621
prkdc	rif1	ENSEEEP00000052659	ENSEEEP00000008598	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	Replication timing regulatory factor 1.	0.627
rif1	ENSEEEP00000018711	ENSEEEP00000008598	ENSEEEP00000018711	Replication timing regulatory factor 1.	Zgc:101664.	0.407