(55 nodes) ATPase, AAA-type, core network (Electrophorus electricus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pex1	Peroxisomal biogenesis factor 1. (1180 aa)
	fignl1	AAA domain-containing protein; Belongs to the AAA ATPase family. (667 aa)
	rfc2	AAA domain-containing protein. (369 aa)
	nvl	Nuclear VCP-like. (865 aa)
	rfc1	Replication factor C subunit 1. (1124 aa)
	LOC113591259	AAA domain-containing protein. (713 aa)
	orc1	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (893 aa)
	LOC113581259	YME1-like 1a. (783 aa)
	vps4b	Uncharacterized protein; Belongs to the AAA ATPase family. (528 aa)
	rfc5	AAA domain-containing protein. (363 aa)
	LOC113571724	AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
	atad1	AAA domain-containing protein; Belongs to the AAA ATPase family. (365 aa)
	trip13	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (423 aa)
	psmc2	Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (483 aa)
	psmc6	AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa)
	psmc4	AAA domain-containing protein; Belongs to the AAA ATPase family. (418 aa)
	lonp1	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. (980 aa)
	atad2b	ATPase family, AAA domain containing 2B. (1390 aa)
	psmc3	AAA domain-containing protein; Belongs to the AAA ATPase family. (427 aa)
	LOC113577203	Uncharacterized protein; Belongs to the AAA ATPase family. (420 aa)
	Nav3	AAA domain-containing protein. (453 aa)
	lonp2	Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import; Belongs to the peptidase S16 family. ECO:0000256\|PROSITE-. (843 aa)
	clpx	Uncharacterized protein. (627 aa)
	chtf18	AAA domain-containing protein. (936 aa)
	LOC113581788	Neuron navigator 2b. (1961 aa)
	LOC113584168	Uncharacterized protein. (769 aa)
	LOC113570874	AAA domain-containing protein. (734 aa)
	VPS4B	Vacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (466 aa)
	spast	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...] (598 aa)
	iqca1	IQ motif containing with AAA domain 1. (853 aa)
	LOC113571879	AAA domain-containing protein. (771 aa)
	katnal2	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. (435 aa)
	LOC113587542	Zgc:153738. (770 aa)
	spg7	AAA domain-containing protein. (800 aa)
	LOC113571385	AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
	LOC113592019	Zgc:136908; Belongs to the AAA ATPase family. (806 aa)
	LOC113590894	Uncharacterized protein; Belongs to the AAA ATPase family. (436 aa)
	afg3l2	AAA domain-containing protein. (768 aa)
	LOC113588541	AAA domain-containing protein; Belongs to the AAA ATPase family. (392 aa)
	ATAD3A	AAA domain-containing protein. (641 aa)
	vcp	Uncharacterized protein; Belongs to the AAA ATPase family. (806 aa)
	spata5l1	Uncharacterized protein. (765 aa)
	psmc5	AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
	pex6	Peroxisomal biogenesis factor 6. (1084 aa)
	nav2	Neuron navigator 2a. (1633 aa)
	SPATA5	Uncharacterized protein. (868 aa)
	FIGNL2	Fidgetin like 2. (447 aa)
	LOC113579893	Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. (486 aa)
	CLPB	ClpB homolog, mitochondrial AAA ATPase chaperonin. (677 aa)
	atad2	Bromo domain-containing protein. (1398 aa)
	LOC113588777	N-ethylmaleimide-sensitive factor a. (730 aa)
	katnal1	Katanin p60 ATPase-containing subunit A-like 1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily. (489 aa)
	LOC113573129	Caseinolytic mitochondrial matrix peptidase chaperone subunit b. (356 aa)
	rfc4	AAA domain-containing protein. (357 aa)
	wrnip1	AAA domain-containing protein. (525 aa)

Your Current Organism:

Electrophorus electricus

NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLPB	LOC113570874	ENSEEEP00000008741	ENSEEEP00000036041	ClpB homolog, mitochondrial AAA ATPase chaperonin.	AAA domain-containing protein.	0.430
CLPB	LOC113571879	ENSEEEP00000008741	ENSEEEP00000039655	ClpB homolog, mitochondrial AAA ATPase chaperonin.	AAA domain-containing protein.	0.430
CLPB	LOC113573129	ENSEEEP00000008741	ENSEEEP00000003357	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Caseinolytic mitochondrial matrix peptidase chaperone subunit b.	0.548
CLPB	LOC113577203	ENSEEEP00000008741	ENSEEEP00000028328	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.430
CLPB	LOC113581259	ENSEEEP00000008741	ENSEEEP00000019196	ClpB homolog, mitochondrial AAA ATPase chaperonin.	YME1-like 1a.	0.467
CLPB	LOC113591259	ENSEEEP00000008741	ENSEEEP00000013836	ClpB homolog, mitochondrial AAA ATPase chaperonin.	AAA domain-containing protein.	0.467
CLPB	afg3l2	ENSEEEP00000008741	ENSEEEP00000045997	ClpB homolog, mitochondrial AAA ATPase chaperonin.	AAA domain-containing protein.	0.430
CLPB	clpx	ENSEEEP00000008741	ENSEEEP00000032297	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Uncharacterized protein.	0.548
CLPB	katnal2	ENSEEEP00000008741	ENSEEEP00000039994	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	0.597
CLPB	lonp1	ENSEEEP00000008741	ENSEEEP00000025034	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	0.867
CLPB	lonp2	ENSEEEP00000008741	ENSEEEP00000030579	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import; Belongs to the peptidase S16 family. ECO:0000256\|PROSITE-.	0.867
CLPB	spg7	ENSEEEP00000008741	ENSEEEP00000041255	ClpB homolog, mitochondrial AAA ATPase chaperonin.	AAA domain-containing protein.	0.430
FIGNL2	LOC113590894	ENSEEEP00000009133	ENSEEEP00000045177	Fidgetin like 2.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.474
FIGNL2	VPS4B	ENSEEEP00000009133	ENSEEEP00000036569	Fidgetin like 2.	Vacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family.	0.476
FIGNL2	psmc3	ENSEEEP00000009133	ENSEEEP00000028233	Fidgetin like 2.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.411
FIGNL2	vps4b	ENSEEEP00000009133	ENSEEEP00000019865	Fidgetin like 2.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.479
LOC113570874	CLPB	ENSEEEP00000036041	ENSEEEP00000008741	AAA domain-containing protein.	ClpB homolog, mitochondrial AAA ATPase chaperonin.	0.430
LOC113570874	LOC113573129	ENSEEEP00000036041	ENSEEEP00000003357	AAA domain-containing protein.	Caseinolytic mitochondrial matrix peptidase chaperone subunit b.	0.565
LOC113570874	clpx	ENSEEEP00000036041	ENSEEEP00000032297	AAA domain-containing protein.	Uncharacterized protein.	0.565
LOC113570874	lonp1	ENSEEEP00000036041	ENSEEEP00000025034	AAA domain-containing protein.	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	0.579