(11 nodes) MIT domain network (Electrophorus electricus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC113590894	Uncharacterized protein; Belongs to the AAA ATPase family. (436 aa)
	snx15	Sorting nexin 15. (378 aa)
	mitd1	MIT domain-containing protein. (246 aa)
	ulk3	Unc-51 like kinase 3; Belongs to the protein kinase superfamily. (447 aa)
	spart	MIT domain-containing protein. (590 aa)
	LOC113582272	MIT domain-containing protein. (601 aa)
	rps6kl1	Ribosomal protein S6 kinase-like 1. (517 aa)
	vps4b	Uncharacterized protein; Belongs to the AAA ATPase family. (528 aa)
	VPS4B	Vacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (466 aa)
	spast	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...] (598 aa)
	capn7	Calpain 7; Belongs to the peptidase C2 family. (816 aa)

Your Current Organism:

Electrophorus electricus

NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC113582272	mitd1	ENSEEEP00000018690	ENSEEEP00000007105	MIT domain-containing protein.	MIT domain-containing protein.	0.426
LOC113582272	snx15	ENSEEEP00000018690	ENSEEEP00000004102	MIT domain-containing protein.	Sorting nexin 15.	0.581
LOC113582272	spart	ENSEEEP00000018690	ENSEEEP00000012329	MIT domain-containing protein.	MIT domain-containing protein.	0.903
LOC113590894	VPS4B	ENSEEEP00000045177	ENSEEEP00000036569	Uncharacterized protein; Belongs to the AAA ATPase family.	Vacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family.	0.938
LOC113590894	spast	ENSEEEP00000045177	ENSEEEP00000036698	Uncharacterized protein; Belongs to the AAA ATPase family.	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...]	0.446
LOC113590894	vps4b	ENSEEEP00000045177	ENSEEEP00000019865	Uncharacterized protein; Belongs to the AAA ATPase family.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.405
VPS4B	LOC113590894	ENSEEEP00000036569	ENSEEEP00000045177	Vacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.938
VPS4B	spast	ENSEEEP00000036569	ENSEEEP00000036698	Vacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family.	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...]	0.453
mitd1	LOC113582272	ENSEEEP00000007105	ENSEEEP00000018690	MIT domain-containing protein.	MIT domain-containing protein.	0.426
snx15	LOC113582272	ENSEEEP00000004102	ENSEEEP00000018690	Sorting nexin 15.	MIT domain-containing protein.	0.581
snx15	spart	ENSEEEP00000004102	ENSEEEP00000012329	Sorting nexin 15.	MIT domain-containing protein.	0.581
spart	LOC113582272	ENSEEEP00000012329	ENSEEEP00000018690	MIT domain-containing protein.	MIT domain-containing protein.	0.903
spart	snx15	ENSEEEP00000012329	ENSEEEP00000004102	MIT domain-containing protein.	Sorting nexin 15.	0.581
spart	spast	ENSEEEP00000012329	ENSEEEP00000036698	MIT domain-containing protein.	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...]	0.558
spast	LOC113590894	ENSEEEP00000036698	ENSEEEP00000045177	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...]	Uncharacterized protein; Belongs to the AAA ATPase family.	0.446
spast	VPS4B	ENSEEEP00000036698	ENSEEEP00000036569	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...]	Vacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family.	0.453
spast	spart	ENSEEEP00000036698	ENSEEEP00000012329	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...]	MIT domain-containing protein.	0.558
spast	vps4b	ENSEEEP00000036698	ENSEEEP00000019865	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...]	Uncharacterized protein; Belongs to the AAA ATPase family.	0.454
vps4b	LOC113590894	ENSEEEP00000019865	ENSEEEP00000045177	Uncharacterized protein; Belongs to the AAA ATPase family.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.405
vps4b	spast	ENSEEEP00000019865	ENSEEEP00000036698	Uncharacterized protein; Belongs to the AAA ATPase family.	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...]	0.454