(120 nodes) Tyrosine-protein kinase, active site network (Electrophorus electricus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ryk	Uncharacterized protein. (599 aa)
	LOC113583945	Tyrosine-protein kinase. (1088 aa)
	frk	Tyrosine-protein kinase. (545 aa)
	LOC113569917	Tyrosine-protein kinase. (482 aa)
	egfr	Receptor protein-tyrosine kinase. (1253 aa)
	ENSEEEP00000012110	TXK tyrosine kinase. (185 aa)
	tesk1	Protein kinase domain-containing protein. (724 aa)
	LOC113571635	Macrophage stimulating 1 receptor a. (1355 aa)
	mst1r	Macrophage stimulating 1 receptor b. (1354 aa)
	plk4	Uncharacterized protein. (923 aa)
	LOC113591513	Tyrosine-protein kinase. (1048 aa)
	ENSEEEP00000013630	Protein kinase domain-containing protein. (185 aa)
	ENSEEEP00000013913	Protein kinase domain-containing protein. (257 aa)
	ddr2	Discoidin domain receptor tyrosine kinase 2a. (848 aa)
	Ror1	Protein kinase domain-containing protein. (216 aa)
	tec	Tyrosine-protein kinase. (577 aa)
	LOC113573820	Eph-like kinase 1. (974 aa)
	LOC113591595	V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b; Belongs to the protein kinase superfamily. Tyr protein kinase family. (895 aa)
	LOC113579628	Tyrosine-protein kinase. (549 aa)
	LOC113592227	Protein kinase domain-containing protein. (443 aa)
	LOC113569980	Eph receptor B2a. (1045 aa)
	tie1	Uncharacterized protein. (1083 aa)
	flt4	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1371 aa)
	LOC113586791	Discoidin domain receptor family, member 2, like. (871 aa)
	blk	Si:ch73-340m8.2. (468 aa)
	ENSEEEP00000003635	Tyrosine-protein kinase receptor. (566 aa)
	ptk2b	Protein tyrosine kinase 2 beta, a; Belongs to the protein kinase superfamily. Tyr protein kinase family. (956 aa)
	LOC113577840	Tyrosine-protein kinase. (459 aa)
	LOC113570150	Tyrosine-protein kinase. (1164 aa)
	itk	Tyrosine-protein kinase. (615 aa)
	hck	Tyrosine-protein kinase. (505 aa)
	epha8	Uncharacterized protein. (992 aa)
	LOC113588272	Eph receptor A4b. (889 aa)
	LOC113577814	Tyrosine-protein kinase receptor. (1359 aa)
	epha3	Eph receptor A3. (940 aa)
	LOC113570609	Receptor protein-tyrosine kinase. (886 aa)
	LOC113582440	Kinase insert domain receptor like; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1251 aa)
	tnk1	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (736 aa)
	CSF1R	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (964 aa)
	ENSEEEP00000027336	Eph receptor A6; Belongs to the protein kinase superfamily. Tyr protein kinase family. (349 aa)
	LOC113570125	Eph receptor B3a. (915 aa)
	LOC113590638	Tyrosine-protein kinase. (539 aa)
	LOC113586324	Eph receptor B2b. (1002 aa)
	LOC113584566	Tyrosine-protein kinase. (1125 aa)
	LOC113586228	Tyrosine-protein kinase. (541 aa)
	LOC113573874	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1246 aa)
	LOC113588329	Protein kinase domain-containing protein. (705 aa)
	epha2	Eph receptor A2 b. (978 aa)
	csf1r	Colony stimulating factor 1 receptor, a. (955 aa)
	pdgfrb	Platelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1103 aa)
	ENSEEEP00000031355	Tyrosine-protein kinase receptor. (714 aa)
	btk	Tyrosine-protein kinase. (637 aa)
	LOC113584152	Insulin receptor a. (1387 aa)
	LOC113572439	Tyrosine-protein kinase. (537 aa)
	ephb4	Uncharacterized protein. (981 aa)
	fes	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (834 aa)
	fer	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (777 aa)
	LOC113587946	Receptor protein-tyrosine kinase. (1111 aa)
	ntrk3	Tyrosine-protein kinase receptor. (814 aa)
	LOC113576673	Tyrosine-protein kinase receptor. (1478 aa)
	ret	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1066 aa)
	jak3	Tyrosine-protein kinase. (1154 aa)
	LOC113575095	Tyrosine-protein kinase. (608 aa)
	LOC113584262	Uncharacterized protein. (823 aa)
	LOC113587903	Eph receptor A4, like. (964 aa)
	fgr	Tyrosine-protein kinase. (541 aa)
	LOC113579192	Receptor protein-tyrosine kinase. (757 aa)
	LOC113571245	Protein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1087 aa)
	erbb4	Receptor protein-tyrosine kinase. (1408 aa)
	LOC113567645	Discoidin domain receptor tyrosine kinase 1. (644 aa)
	LOC113584773	Tyrosine-protein kinase receptor. (690 aa)
	LOC113577904	Apoptosis-associated tyrosine kinase a. (1500 aa)
	kdr	Kinase insert domain receptor (a type III receptor tyrosine kinase); Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1321 aa)
	kit	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (984 aa)
	pdgfra	Platelet-derived growth factor receptor, alpha polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1064 aa)
	ror2	Receptor tyrosine kinase-like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (915 aa)
	syk	Tyrosine-protein kinase. (612 aa)
	ntrk1	Tyrosine-protein kinase receptor. (623 aa)
	fgfr4	Fibroblast growth factor receptor. (888 aa)
	LOC113577966	Eph receptor A2 a. (937 aa)
	fgfr2	Fibroblast growth factor receptor. (806 aa)
	LOC113573593	Tyrosine-protein kinase receptor. (1394 aa)
	fgfr3	Fibroblast growth factor receptor. (789 aa)
	tesk2	Testis associated actin remodelling kinase 2. (630 aa)
	mertk	C-mer proto-oncogene tyrosine kinase a. (925 aa)
	LOC113579757	Tyrosine-protein kinase. (453 aa)
	LOC113576164	Tyrosine kinase, non-receptor, 2a; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1015 aa)
	LOC113572915	Tyrosine-protein kinase. (1141 aa)
	tek	Uncharacterized protein. (1125 aa)
	erbb2	Receptor protein-tyrosine kinase. (1224 aa)
	LOC113573646	Pseudopodium-enriched atypical kinase 1. (1768 aa)
	LOC113571979	Tyrosine-protein kinase. (525 aa)
	speg	SPEG complex locus a. (2939 aa)
	LOC113576303	Tyrosine-protein kinase. (561 aa)
	LOC113573003	Protein tyrosine kinase 2 beta, b; Belongs to the protein kinase superfamily. Tyr protein kinase family. (995 aa)
	LOC113576333	Tyrosine-protein kinase. (482 aa)
	LOC113573022	Si:dkey-40m6.8. (1605 aa)
	ptk7	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1064 aa)
	LOC113569739	Si:ch211-167j9.5. (313 aa)
	tp53rk	Protein kinase domain-containing protein. (168 aa)
	LOC113568219	EPH receptor B1. (424 aa)
	AXL	Uncharacterized protein. (912 aa)
	nek10	NIMA-related kinase 10. (902 aa)
	MUSK	Muscle associated receptor tyrosine kinase. (935 aa)
	epha5	Uncharacterized protein. (957 aa)
	LOC113572036	Tyrosine-protein kinase. (584 aa)
	LYN	Tyrosine-protein kinase. (502 aa)
	LOC113588173	Fibroblast growth factor receptor. (793 aa)
	ephb3	EPH receptor B3. (999 aa)
	tyro3	TYRO3 protein tyrosine kinase. (863 aa)
	epha7	Uncharacterized protein. (1008 aa)
	lmtk2	Lemur tyrosine kinase 2. (1434 aa)
	CSK	Tyrosine-protein kinase. (463 aa)
	tyk2	Tyrosine-protein kinase. (1175 aa)
	ENSEEEP00000010450	ALK receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. (572 aa)
	LOC113586501	Tyrosine-protein kinase receptor. (1386 aa)
	ENSEEEP00000000755	Protein kinase domain-containing protein. (217 aa)
	met	Uncharacterized protein. (1359 aa)
	aatk	Apoptosis-associated tyrosine kinase b. (1437 aa)
	yes1	Tyrosine-protein kinase. (549 aa)

Your Current Organism:

Electrophorus electricus

NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSF1R	fer	ENSEEEP00000027267	ENSEEEP00000033498	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.	0.477
CSF1R	fes	ENSEEEP00000027267	ENSEEEP00000033252	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.	0.477
CSK	ENSEEEP00000000755	ENSEEEP00000009149	ENSEEEP00000000755	Tyrosine-protein kinase.	Protein kinase domain-containing protein.	0.541
CSK	ENSEEEP00000013630	ENSEEEP00000009149	ENSEEEP00000013630	Tyrosine-protein kinase.	Protein kinase domain-containing protein.	0.601
CSK	LOC113569917	ENSEEEP00000009149	ENSEEEP00000011641	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.647
CSK	LOC113571245	ENSEEEP00000009149	ENSEEEP00000038126	Tyrosine-protein kinase.	Protein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.597
CSK	LOC113571635	ENSEEEP00000009149	ENSEEEP00000012441	Tyrosine-protein kinase.	Macrophage stimulating 1 receptor a.	0.541
CSK	LOC113571979	ENSEEEP00000009149	ENSEEEP00000049040	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.647
CSK	LOC113572439	ENSEEEP00000009149	ENSEEEP00000032703	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.696
CSK	LOC113573003	ENSEEEP00000009149	ENSEEEP00000050993	Tyrosine-protein kinase.	Protein tyrosine kinase 2 beta, b; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.597
CSK	LOC113575095	ENSEEEP00000009149	ENSEEEP00000036961	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.462
CSK	LOC113576303	ENSEEEP00000009149	ENSEEEP00000050391	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.696
CSK	LOC113576333	ENSEEEP00000009149	ENSEEEP00000051004	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.679
CSK	LOC113579192	ENSEEEP00000009149	ENSEEEP00000038038	Tyrosine-protein kinase.	Receptor protein-tyrosine kinase.	0.464
CSK	LOC113579628	ENSEEEP00000009149	ENSEEEP00000016701	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.647
CSK	LOC113586228	ENSEEEP00000009149	ENSEEEP00000028780	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.614
CSK	LOC113587946	ENSEEEP00000009149	ENSEEEP00000033975	Tyrosine-protein kinase.	Receptor protein-tyrosine kinase.	0.464
CSK	LOC113590638	ENSEEEP00000009149	ENSEEEP00000027494	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.613
CSK	LOC113592227	ENSEEEP00000009149	ENSEEEP00000016863	Tyrosine-protein kinase.	Protein kinase domain-containing protein.	0.464
CSK	LYN	ENSEEEP00000009149	ENSEEEP00000003182	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.651