(15 nodes) PIN-like domain superfamily network (Electrophorus electricus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSEEEP00000027215	XPGN domain-containing protein. (302 aa)
	Fam120b	Family with sequence similarity 120B. (534 aa)
	fam120a	Family with sequence similarity 120A. (1095 aa)
	fen1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
	LOC113590030	Uncharacterized protein. (347 aa)
	utp23	Uncharacterized protein. (254 aa)
	smg6	SMG6 nonsense mediated mRNA decay factor. (1575 aa)
	ENSEEEP00000043756	XPGI domain-containing protein. (341 aa)
	ASTE1	XPG_I_2 domain-containing protein. (697 aa)
	dis3	Uncharacterized protein; Belongs to the RNR ribonuclease family. (948 aa)
	fam120c	Family with sequence similarity 120C. (894 aa)
	fcf1	PINc domain-containing protein. (197 aa)
	exo1	Exonuclease 1. (771 aa)
	LOC113574413	Uncharacterized protein. (682 aa)
	Ercc5	XPGI domain-containing protein. (396 aa)

Your Current Organism:

Electrophorus electricus

NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSEEEP00000027215	Ercc5	ENSEEEP00000027215	ENSEEEP00000027213	XPGN domain-containing protein.	XPGI domain-containing protein.	0.926
ENSEEEP00000043756	exo1	ENSEEEP00000043756	ENSEEEP00000019719	XPGI domain-containing protein.	Exonuclease 1.	0.717
Ercc5	ENSEEEP00000027215	ENSEEEP00000027213	ENSEEEP00000027215	XPGI domain-containing protein.	XPGN domain-containing protein.	0.926
LOC113590030	exo1	ENSEEEP00000033260	ENSEEEP00000019719	Uncharacterized protein.	Exonuclease 1.	0.836
LOC113590030	fen1	ENSEEEP00000033260	ENSEEEP00000032875	Uncharacterized protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.905
dis3	fcf1	ENSEEEP00000010283	ENSEEEP00000018967	Uncharacterized protein; Belongs to the RNR ribonuclease family.	PINc domain-containing protein.	0.423
exo1	ENSEEEP00000043756	ENSEEEP00000019719	ENSEEEP00000043756	Exonuclease 1.	XPGI domain-containing protein.	0.717
exo1	LOC113590030	ENSEEEP00000019719	ENSEEEP00000033260	Exonuclease 1.	Uncharacterized protein.	0.836
exo1	fen1	ENSEEEP00000019719	ENSEEEP00000032875	Exonuclease 1.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.836
fcf1	dis3	ENSEEEP00000018967	ENSEEEP00000010283	PINc domain-containing protein.	Uncharacterized protein; Belongs to the RNR ribonuclease family.	0.423
fcf1	utp23	ENSEEEP00000018967	ENSEEEP00000033929	PINc domain-containing protein.	Uncharacterized protein.	0.846
fen1	LOC113590030	ENSEEEP00000032875	ENSEEEP00000033260	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.905
fen1	exo1	ENSEEEP00000032875	ENSEEEP00000019719	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Exonuclease 1.	0.836
utp23	fcf1	ENSEEEP00000033929	ENSEEEP00000018967	Uncharacterized protein.	PINc domain-containing protein.	0.846