(14 nodes) Rhomboid-like superfamily network (Electrophorus electricus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PARL	Rhomboid domain-containing protein. (360 aa)
	rhbdf1	Rhomboid domain-containing protein. (857 aa)
	rhbdl1	Rhomboid, veinlet-like 1 (Drosophila); Belongs to the peptidase S54 family. (374 aa)
	RHBDF2	Rhomboid 5 homolog 2. (739 aa)
	derl2	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
	ubac2	UBA domain containing 2. (415 aa)
	rhbdl3	Rhomboid, veinlet-like 3 (Drosophila); Belongs to the peptidase S54 family. (409 aa)
	LOC113574864	Rhomboid 5 homolog 1b (Drosophila). (793 aa)
	rhbdl2	Rhomboid domain-containing protein; Belongs to the peptidase S54 family. (293 aa)
	rhbdd3	Rhomboid domain-containing protein. (378 aa)
	rhbdd1	Rhomboid domain-containing protein. (334 aa)
	derl1	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (261 aa)
	rhbdd2	Rhomboid domain-containing protein. (387 aa)
	tmem115	Uncharacterized protein. (360 aa)

Your Current Organism:

Electrophorus electricus

NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC113574864	PARL	ENSEEEP00000020847	ENSEEEP00000046459	Rhomboid 5 homolog 1b (Drosophila).	Rhomboid domain-containing protein.	0.433
PARL	LOC113574864	ENSEEEP00000046459	ENSEEEP00000020847	Rhomboid domain-containing protein.	Rhomboid 5 homolog 1b (Drosophila).	0.433
PARL	RHBDF2	ENSEEEP00000046459	ENSEEEP00000007296	Rhomboid domain-containing protein.	Rhomboid 5 homolog 2.	0.433
PARL	rhbdd1	ENSEEEP00000046459	ENSEEEP00000031177	Rhomboid domain-containing protein.	Rhomboid domain-containing protein.	0.440
PARL	rhbdd2	ENSEEEP00000046459	ENSEEEP00000036419	Rhomboid domain-containing protein.	Rhomboid domain-containing protein.	0.440
PARL	rhbdd3	ENSEEEP00000046459	ENSEEEP00000026212	Rhomboid domain-containing protein.	Rhomboid domain-containing protein.	0.440
PARL	rhbdf1	ENSEEEP00000046459	ENSEEEP00000002273	Rhomboid domain-containing protein.	Rhomboid domain-containing protein.	0.433
PARL	rhbdl1	ENSEEEP00000046459	ENSEEEP00000006697	Rhomboid domain-containing protein.	Rhomboid, veinlet-like 1 (Drosophila); Belongs to the peptidase S54 family.	0.418
PARL	rhbdl2	ENSEEEP00000046459	ENSEEEP00000021492	Rhomboid domain-containing protein.	Rhomboid domain-containing protein; Belongs to the peptidase S54 family.	0.564
PARL	rhbdl3	ENSEEEP00000046459	ENSEEEP00000012937	Rhomboid domain-containing protein.	Rhomboid, veinlet-like 3 (Drosophila); Belongs to the peptidase S54 family.	0.463
PARL	tmem115	ENSEEEP00000046459	ENSEEEP00000044144	Rhomboid domain-containing protein.	Uncharacterized protein.	0.414
PARL	ubac2	ENSEEEP00000046459	ENSEEEP00000010172	Rhomboid domain-containing protein.	UBA domain containing 2.	0.465
RHBDF2	PARL	ENSEEEP00000007296	ENSEEEP00000046459	Rhomboid 5 homolog 2.	Rhomboid domain-containing protein.	0.433
derl1	derl2	ENSEEEP00000033689	ENSEEEP00000009655	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.996
derl1	ubac2	ENSEEEP00000033689	ENSEEEP00000010172	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	UBA domain containing 2.	0.591
derl2	derl1	ENSEEEP00000009655	ENSEEEP00000033689	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.996
derl2	ubac2	ENSEEEP00000009655	ENSEEEP00000010172	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	UBA domain containing 2.	0.402
rhbdd1	PARL	ENSEEEP00000031177	ENSEEEP00000046459	Rhomboid domain-containing protein.	Rhomboid domain-containing protein.	0.440
rhbdd2	PARL	ENSEEEP00000036419	ENSEEEP00000046459	Rhomboid domain-containing protein.	Rhomboid domain-containing protein.	0.440
rhbdd2	rhbdd3	ENSEEEP00000036419	ENSEEEP00000026212	Rhomboid domain-containing protein.	Rhomboid domain-containing protein.	0.581