STRINGSTRING
LOC113573558 LOC113573558 rpa2 rpa2 LOC113584157 LOC113584157 LOC113571385 LOC113571385 wee2 wee2 akt1 akt1 psmd2 psmd2 orc2 orc2 orc5 orc5 LOC113578084 LOC113578084 LOC113576303 LOC113576303 mcm2 mcm2 LOC113574737 LOC113574737 psmd9 psmd9 ppp4r1 ppp4r1 psmc5 psmc5 mnat1 mnat1 ccne2 ccne2 uba52 uba52 LOC113581961 LOC113581961 LOC113581273 LOC113581273 LOC113581261 LOC113581261 LOC113581260 LOC113581260 ENSEEEP00000047948 ENSEEEP00000047948 LOC113581270 LOC113581270 mcm6 mcm6 LOC113591951 LOC113591951 LOC113572915 LOC113572915 LOC113591847 LOC113591847 skp1 skp1 ppp2ca ppp2ca CCNE2 CCNE2 kxd1 kxd1 rbl2 rbl2 rb1 rb1 rps27a rps27a cdkn2d cdkn2d ppp2r3a ppp2r3a fndc3b fndc3b LOC113583945 LOC113583945 mcm3 mcm3 ccna1 ccna1 psmd4 psmd4 LOC113572613 LOC113572613 cables1 cables1 prim1 prim1 LOC113575491 LOC113575491 LOC113568414 LOC113568414 e2f4 e2f4 psme1 psme1 mcm9 mcm9 mcm10 mcm10 psmb2 psmb2 ccnd2 ccnd2 akt3 akt3 mcm5 mcm5 psmd6 psmd6 pola1 pola1 ENSEEEP00000017695 ENSEEEP00000017695 orc1 orc1 ENSEEEP00000017941 ENSEEEP00000017941 Pole Pole ppp2cb ppp2cb ENSEEEP00000017953 ENSEEEP00000017953 ENSEEEP00000018268 ENSEEEP00000018268 psmb1 psmb1 cdk2 cdk2 ENSEEEP00000018543 ENSEEEP00000018543 orc3 orc3 psma5 psma5 mcm8 mcm8 LOC113582289 LOC113582289 orc4 orc4 psmd5 psmd5 LOC113571685 LOC113571685 CDC25B CDC25B LOC113571395 LOC113571395 LOC113585437 LOC113585437 LOC113578388 LOC113578388 LOC113573654 LOC113573654 LOC113588714 LOC113588714 LOC113585995 LOC113585995 LOC113572522 LOC113572522 rpa1 rpa1 ENSEEEP00000001655 ENSEEEP00000001655 cdkn2c cdkn2c ENSEEEP00000001789 ENSEEEP00000001789 ENSEEEP00000001790 ENSEEEP00000001790 LOC113592042 LOC113592042 LOC113584344 LOC113584344 LOC113584345 LOC113584345 psma1 psma1 ENSEEEP00000004035 ENSEEEP00000004035 LOC113587140 LOC113587140 LOC113588778 LOC113588778 psmf1 psmf1 rbl1 rbl1 LOC113591075 LOC113591075 LOC113573723 LOC113573723 LOC113587211 LOC113587211 skp2 skp2 LOC113583840 LOC113583840 LOC113586037 LOC113586037 dbf4 dbf4 psma2 psma2 LOC113571529 LOC113571529 LOC113584375 LOC113584375 LOC113571724 LOC113571724 psmb7 psmb7 psmc2 psmc2 cdc45 cdc45 pola2 pola2 mcm4 mcm4 psmc6 psmc6 mybl2 mybl2 LOC113586168 LOC113586168 lin54 lin54 cdc7 cdc7 psmc4 psmc4 e2f1 e2f1 LOC113574414 LOC113574414 psme3 psme3 rpa3 rpa3 ppp4r4 ppp4r4 tfdp1 tfdp1 ccne1 ccne1 dyrk1a dyrk1a LOC113587414 LOC113587414 ppp2r3c ppp2r3c psma6 psma6 cdk7 cdk7 CDKN2B CDKN2B orc6 orc6 psmc3 psmc3 LOC113577231 LOC113577231 LOC113584566 LOC113584566 psmb4 psmb4 psmd1 psmd1 LOC113585754 LOC113585754 lin9 lin9 LOC113574541 LOC113574541 pole4 pole4 psmd14 psmd14 psmd7 psmd7 WEE1 WEE1 LOC113589639 LOC113589639 pole3 pole3 ENSEEEP00000031801 ENSEEEP00000031801 cdkn1a cdkn1a gmnn gmnn ccna2 ccna2 cdk4 cdk4 LOC113572439 LOC113572439 ENSEEEP00000034549 ENSEEEP00000034549 LOC113579598 LOC113579598 LOC113582095 LOC113582095 psmd10 psmd10 LOC113591897 LOC113591897 psmd3 psmd3 ccnh ccnh LOC113579639 LOC113579639 lin52 lin52 cdc6 cdc6 prr5l prr5l relch relch LOC113567554 LOC113567554 LOC113577872 LOC113577872 LOC113583571 LOC113583571 ENSEEEP00000037560 ENSEEEP00000037560 ENSEEEP00000037744 ENSEEEP00000037744 ENSEEEP00000037746 ENSEEEP00000037746 psma4 psma4 ccnd1 ccnd1 psmb3 psmb3 LOC113591355 LOC113591355 LOC113579698 LOC113579698 psmd12 psmd12 fnbp4 fnbp4 ENSEEEP00000040766 ENSEEEP00000040766 LOC113589194 LOC113589194 psma3 psma3 cdt1 cdt1 lin37 lin37 fndc3a fndc3a mcm7 mcm7 LOC113576121 LOC113576121 psmd8 psmd8 psme2 psme2 LOC113588422 LOC113588422 cdk6 cdk6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC113573558Uncharacterized protein. (174 aa)
rpa2RPA_C domain-containing protein. (280 aa)
LOC113584157Ubiquitin-like domain-containing protein. (77 aa)
LOC113571385AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
wee2Wee1-like protein kinase. (542 aa)
akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (489 aa)
psmd226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (898 aa)
orc2Origin recognition complex, subunit 2. (491 aa)
orc5AAA_16 domain-containing protein. (444 aa)
LOC113578084Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (293 aa)
LOC113576303Tyrosine-protein kinase. (561 aa)
mcm2DNA helicase; Belongs to the MCM family. (908 aa)
LOC113574737Transcription factor. (426 aa)
psmd9PDZ domain-containing protein. (213 aa)
ppp4r1Uncharacterized protein. (1011 aa)
psmc5AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
mnat1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (311 aa)
ccne2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (394 aa)
uba52Ubiquitin-like domain-containing protein. (128 aa)
LOC113581961Cdk5 and Abl enzyme substrate 2a. (368 aa)
LOC113581273Proteasome subunit beta. (218 aa)
LOC113581261Proteasome subunit beta. (238 aa)
LOC113581260Proteasome subunit beta. (277 aa)
ENSEEEP00000047948Uncharacterized protein. (713 aa)
LOC113581270Proteasome subunit beta. (281 aa)
mcm6DNA helicase; Belongs to the MCM family. (830 aa)
LOC113591951EF-hand domain-containing protein. (581 aa)
LOC113572915Tyrosine-protein kinase. (1141 aa)
LOC113591847Transcription factor. (417 aa)
skp1Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
ppp2caSerine/threonine-protein phosphatase. (309 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (320 aa)
kxd1KxDL domain-containing protein. (183 aa)
rbl2Retinoblastoma-like 2 (p130). (1095 aa)
rb1Retinoblastoma 1. (901 aa)
rps27aUbiquitin-like domain-containing protein. (156 aa)
cdkn2dANK_REP_REGION domain-containing protein. (167 aa)
ppp2r3aUncharacterized protein. (1193 aa)
fndc3bUncharacterized protein. (1206 aa)
LOC113583945Tyrosine-protein kinase. (1088 aa)
mcm3DNA helicase; Belongs to the MCM family. (815 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (322 aa)
psmd4VWFA domain-containing protein. (373 aa)
LOC113572613Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
cables1Cyclin N-terminal domain-containing protein. (537 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (422 aa)
LOC113575491Tyrosine-protein kinase. (509 aa)
LOC113568414Uncharacterized protein; Belongs to the protein kinase superfamily. (459 aa)
e2f4E2F transcription factor 4. (372 aa)
psme1Uncharacterized protein. (250 aa)
mcm9MCM domain-containing protein; Belongs to the MCM family. (1143 aa)
mcm10Mcm10 domain-containing protein. (838 aa)
psmb2Proteasome subunit beta. (199 aa)
ccnd2Cyclin D2, a; Belongs to the cyclin family. (331 aa)
akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (493 aa)
mcm5DNA helicase; Belongs to the MCM family. (738 aa)
psmd6PCI domain-containing protein. (389 aa)
pola1DNA polymerase. (1321 aa)
ENSEEEP00000017695CYCLIN domain-containing protein; Belongs to the cyclin family. (182 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (893 aa)
ENSEEEP00000017941DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (304 aa)
PoleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (708 aa)
ppp2cbSerine/threonine-protein phosphatase. (309 aa)
ENSEEEP00000017953DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (368 aa)
ENSEEEP00000018268V-myb avian myeloblastosis viral oncogene homolog-like 2a. (690 aa)
psmb1Proteasome subunit beta. (243 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (324 aa)
ENSEEEP00000018543Methionine sulfoxide reductase B1b. (259 aa)
orc3Origin recognition complex, subunit 3. (723 aa)
psma5Proteasome subunit alpha type. (241 aa)
mcm8MCM domain-containing protein; Belongs to the MCM family. (844 aa)
LOC113582289Protein kinase domain-containing protein. (667 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (472 aa)
psmd5Proteasome 26S subunit, non-ATPase 5. (600 aa)
LOC113571685Proteasome subunit alpha type. (246 aa)
CDC25BCell division cycle 25B. (551 aa)
LOC113571395Polymerase (DNA directed), epsilon 2. (527 aa)
LOC113585437Proteasome subunit alpha type. (246 aa)
LOC113578388PCI domain-containing protein. (385 aa)
LOC113573654Uncharacterized protein. (206 aa)
LOC113588714E2F transcription factor 5. (360 aa)
LOC113585995DNA helicase; Belongs to the MCM family. (801 aa)
LOC113572522Uncharacterized protein. (194 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (624 aa)
ENSEEEP00000001655E2F_CC-MB domain-containing protein. (244 aa)
cdkn2cANK_REP_REGION domain-containing protein. (166 aa)
ENSEEEP00000001789E2F transcription factor 3. (221 aa)
ENSEEEP00000001790E2F transcription factor 3. (219 aa)
LOC113592042Proteasome subunit beta. (236 aa)
LOC113584344DNA helicase; Belongs to the MCM family. (820 aa)
LOC113584345CULLIN_2 domain-containing protein; Belongs to the cullin family. (777 aa)
psma1Proteasome subunit alpha type. (262 aa)
ENSEEEP00000004035Dpoe2NT domain-containing protein. (82 aa)
LOC113587140Uncharacterized protein; Belongs to the cyclin family. (304 aa)
LOC113588778Proteasome 26S subunit, non-ATPase 11a. (449 aa)
psmf1Uncharacterized protein. (272 aa)
rbl1Uncharacterized protein. (1041 aa)
LOC113591075Proteasome subunit beta. (233 aa)
LOC113573723Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (103 aa)
LOC113587211Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (76 aa)
skp2F-box domain-containing protein. (410 aa)
LOC113583840Proteasome subunit beta. (279 aa)
LOC113586037Serine/threonine-protein phosphatase. (309 aa)
dbf4DBF4 zinc finger. (660 aa)
psma2Proteasome subunit alpha type. (234 aa)
LOC113571529DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (509 aa)
LOC113584375Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, b. (761 aa)
LOC113571724AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
psmb7Proteasome subunit beta. (277 aa)
psmc2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (483 aa)
cdc45Uncharacterized protein. (574 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (600 aa)
mcm4DNA helicase; Belongs to the MCM family. (848 aa)
psmc6AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa)
mybl2Uncharacterized protein. (641 aa)
LOC113586168Cyclin N-terminal domain-containing protein. (162 aa)
lin54CRC domain-containing protein. (808 aa)
cdc7Protein kinase domain-containing protein. (555 aa)
psmc4AAA domain-containing protein; Belongs to the AAA ATPase family. (418 aa)
e2f1E2F transcription factor 1. (431 aa)
LOC113574414Protein kinase domain-containing protein. (749 aa)
psme3Uncharacterized protein. (256 aa)
rpa3Uncharacterized protein. (122 aa)
ppp4r4Protein phosphatase 4, regulatory subunit 4. (757 aa)
tfdp1Transcription factor. (405 aa)
ccne1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (410 aa)
dyrk1aProtein kinase domain-containing protein. (757 aa)
LOC113587414Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (448 aa)
ppp2r3cUncharacterized protein. (456 aa)
psma6Proteasome subunit alpha type. (265 aa)
cdk7Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (345 aa)
CDKN2BANK_REP_REGION domain-containing protein. (145 aa)
orc6Uncharacterized protein. (262 aa)
psmc3AAA domain-containing protein; Belongs to the AAA ATPase family. (427 aa)
LOC113577231RPA_C domain-containing protein. (232 aa)
LOC113584566Tyrosine-protein kinase. (1125 aa)
psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (255 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (992 aa)
LOC113585754Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (443 aa)
lin9DIRP domain-containing protein. (495 aa)
LOC113574541SCY domain-containing protein. (114 aa)
pole4CBFD_NFYB_HMF domain-containing protein. (127 aa)
psmd14MPN domain-containing protein. (330 aa)
psmd7Proteasome 26S subunit, non-ATPase 7. (327 aa)
WEE1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (408 aa)
LOC113589639PCI domain-containing protein. (432 aa)
pole3CBFD_NFYB_HMF domain-containing protein. (149 aa)
ENSEEEP00000031801Cyclin D3; Belongs to the cyclin family. (241 aa)
cdkn1aUncharacterized protein. (166 aa)
gmnnGeminin, DNA replication inhibitor. (208 aa)
ccna2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (428 aa)
cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (292 aa)
LOC113572439Tyrosine-protein kinase. (537 aa)
ENSEEEP00000034549Proteasome endopeptidase complex. (216 aa)
LOC113579598Uncharacterized protein. (662 aa)
LOC113582095Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (443 aa)
psmd10ANK_REP_REGION domain-containing protein. (233 aa)
LOC113591897CULLIN_2 domain-containing protein; Belongs to the cullin family. (560 aa)
psmd3PCI domain-containing protein. (514 aa)
ccnhCYCLIN domain-containing protein; Belongs to the cyclin family. (321 aa)
LOC113579639Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (462 aa)
lin52Lin-52 DREAM MuvB core complex component. (102 aa)
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (543 aa)
prr5lUncharacterized protein. (342 aa)
relchLisH domain-containing protein. (1134 aa)
LOC113567554Proteasome 26S subunit, non-ATPase 13. (366 aa)
LOC113577872Uncharacterized protein. (929 aa)
LOC113583571Uncharacterized protein. (191 aa)
ENSEEEP00000037560Cdk5 and Abl enzyme substrate 2b. (372 aa)
ENSEEEP00000037744E2F transcription factor 3. (210 aa)
ENSEEEP00000037746E2F transcription factor 3. (205 aa)
psma4Proteasome subunit alpha type. (261 aa)
ccnd1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (292 aa)
psmb3Proteasome subunit beta. (205 aa)
LOC113591355Protein phosphatase 2, regulatory subunit A, beta a. (616 aa)
LOC113579698Uncharacterized protein. (217 aa)
psmd12PCI domain-containing protein. (479 aa)
fnbp4Uncharacterized protein. (865 aa)
ENSEEEP00000040766E2F_TDP domain-containing protein. (75 aa)
LOC113589194Proteasome subunit beta. (270 aa)
psma3Proteasome subunit alpha type. (255 aa)
cdt1Chromatin licensing and DNA replication factor 1. (679 aa)
lin37Lin-37 DREAM MuvB core complex component. (180 aa)
fndc3aFibronectin type III domain containing 3A. (1101 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (732 aa)
LOC113576121Fibronectin type III domain containing 3Bb. (1186 aa)
psmd8Proteasome 26S subunit, non-ATPase 8. (280 aa)
psme2Uncharacterized protein. (241 aa)
LOC113588422Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
cdk6Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (324 aa)
Your Current Organism:
Electrophorus electricus
NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish
Server load: low (14%) [HD]